1. Colorectal Cancer Migration and Invasion Initiated by microRNA-106a
- Author
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Tao Tao Dong, Min Hua Zheng, Feng Dong, Hong Chao Zhao, Lin Lin Wang, Hou Min Zhou, and Bo Feng
- Subjects
Male ,Colorectal cancer ,Kaplan-Meier Estimate ,Biochemistry ,Metastasis ,Cell Movement ,Nucleic Acids ,Basic Cancer Research ,Neoplasm Metastasis ,Multidisciplinary ,Reverse Transcriptase Polymerase Chain Reaction ,Cancer Risk Factors ,Colon Adenocarcinoma ,Cell migration ,Primary tumor ,Gene Expression Regulation, Neoplastic ,Oncology ,Disease Progression ,Medicine ,Female ,RNA Interference ,Colorectal Neoplasms ,HT29 Cells ,Research Article ,Cell signaling ,Cell Survival ,Science ,Blotting, Western ,Transplantation, Heterologous ,Genetic Causes of Cancer ,Protein Serine-Threonine Kinases ,Biology ,Rectal Cancer ,Cell Line, Tumor ,Gastrointestinal Tumors ,microRNA ,Genetics ,medicine ,Humans ,Neoplasm Invasiveness ,Cell Proliferation ,Cell growth ,Receptor, Transforming Growth Factor-beta Type II ,Cancers and Neoplasms ,Cancer ,Neoplasms, Experimental ,medicine.disease ,digestive system diseases ,MicroRNAs ,Cancer research ,RNA ,Gene Function ,Receptors, Transforming Growth Factor beta - Abstract
MicroRNAs have been implicated in the regulation of several cellular signaling pathways of colorectal cancer (CRC) cells. Although emerging evidence proves that microRNA (miR)-106a is expressed highly in primary tumor and stool samples of CRC patients; whether or not miR-106a mediates cancer metastasis is unknown. We show here that miR-106a is highly expressed in metastatic CRC cells, and regulates cancer cell migration and invasion positively in vitro and in vivo. These phenotypes do not involve confounding influences on cancer cell proliferation. MiR-106a inhibits the expression of transforming growth factor-β receptor 2 (TGFBR2), leading to increased CRC cell migration and invasion. Importantly, miR-106a expression levels in primary CRCs are correlated with clinical cancer progression. These observations indicate that miR-106a inhibits the anti-metastatic target directly and results in CRC cell migration and invasion.
- Published
- 2012