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8 results on '"Bertolotto, Antonio"'

3. Vitamin D Binding Protein Isoforms and Apolipoprotein E in Cerebrospinal Fluid as Prognostic Biomarkers of Multiple Sclerosis

Author

Perga, Simona, primary, Giuliano Albo, Alessandra, additional, Lis, Katarzyna, additional, Minari, Nicoletta, additional, Falvo, Sara, additional, Marnetto, Fabiana, additional, Caldano, Marzia, additional, Reviglione, Raffaella, additional, Berchialla, Paola, additional, Capobianco, Marco A., additional, Malentacchi, Maria, additional, Corpillo, Davide, additional, and Bertolotto, Antonio, additional

Published
2015
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5. Presence and Significant Determinants of Cognitive Impairment in a Large Sample of Patients with Multiple Sclerosis

Author

Borghi, Martina, primary, Cavallo, Marco, additional, Carletto, Sara, additional, Ostacoli, Luca, additional, Zuffranieri, Marco, additional, Picci, Rocco Luigi, additional, Scavelli, Francesco, additional, Johnston, Harriet, additional, Furlan, Pier Maria, additional, Bertolotto, Antonio, additional, and Malucchi, Simona, additional

Published
2013
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7. Learning from Nature: Pregnancy Changes the Expression of Inflammation-Related Genes in Patients with Multiple Sclerosis

Author

Gilli, Francesca, primary, Lindberg, Raija L. P., additional, Valentino, Paola, additional, Marnetto, Fabiana, additional, Malucchi, Simona, additional, Sala, Arianna, additional, Capobianco, Marco, additional, di Sapio, Alessia, additional, Sperli, Francesca, additional, Kappos, Ludwig, additional, Calogero, Raffaele A., additional, and Bertolotto, Antonio, additional

Published
2010
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8. Development of a Short Version of MSQOL-54 Using Factor Analysis and Item Response Theory

Author

Antonio Bertolotto, Paolo Confalonieri, Alessandra Lugaresi, Rosalba Rosato, Francesco Patti, Maria Grazia Grasso, Anna Toscano, Alessandra Solari, Silvia Testa, Andrea Giordano, Rosato, Rosalba, Testa, Silvia, Bertolotto, Antonio, Confalonieri, Paolo, Patti, Francesco, Lugaresi, Alessandra, Grasso, Maria Grazia, Toscano, Anna, Giordano, Andrea, and Solari, Alessandra

Subjects
Male, Psychometrics, lcsh:Medicine, Social Sciences, QUALITY-OF-LIFE, COMPOSITE MEASUREMENT SCALES, REPORTED OUTCOME MEASURES, MULTIPLE-SCLEROSIS, QUESTIONNAIRE MSQOL-54, RASCH ANALYSIS, VALIDATION, INSTRUMENT, Disability Evaluation, Cognition, Mathematical and Statistical Techniques, 0302 clinical medicine, Quality of life, Multiple Sclerosi, Item response theory, Medicine and Health Sciences, Psychology, Ethnicities, Prospective Studies, 030212 general & internal medicine, lcsh:Science, media_common, Multidisciplinary, Medicine (all), Neurodegenerative Diseases, Middle Aged, Italian People, Neurology, Physical Sciences, Female, Factor Analysis, Statistics (Mathematics), Human, Research Article, Clinical psychology, Adult, medicine.medical_specialty, Multiple Sclerosis, media_common.quotation_subject, Immunology, Research and Analysis Methods, behavioral disciplines and activities, Autoimmune Diseases, 03 medical and health sciences, Mental Health and Psychiatry, medicine, Humans, Quality (business), Statistical Methods, Psychiatry, Aged, Health related quality of life, Biochemistry, Genetics and Molecular Biology (all), lcsh:R, Cognitive Psychology, Biology and Life Sciences, Eigenvalues, Demyelinating Disorders, Health Care, Prospective Studie, Algebra, Agricultural and Biological Sciences (all), Linear Algebra, People and Places, Quality of Life, Cognitive Science, lcsh:Q, Clinical Immunology, Perception, Population Groupings, Clinical Medicine, Factor Analysis, Statistical, Psychomotor Performance, Mathematics, 030217 neurology & neurosurgery, Neuroscience
Abstract

Background: The Multiple Sclerosis Quality of Life-54 (MSQOL-54, 52 items grouped in 12 subscales plus two single items) is the most used MS specific health related quality of life inventory. Objective: To develop a shortened version of the MSQOL-54. Methods: MSQOL-54 dimensionality and metric properties were investigated by confirmatory factor analysis (CFA) and Rasch modelling (Partial Credit Model, PCM) on MSQOL-54s completed by 473 MS patients. Their mean age was 41 years, 65% were women, and median Expanded Disability Status Scale (EDSS) score was 2.0 (range 0-9.5). Differential item functioning (DIF) was evaluated for gender, age and EDSS. Dimensionality of the resulting short version was assessed by exploratory factor analysis (EFA) and CFA. Cognitive debriefing of the short instrument (vs. the original) was then performed on 12 MS patients. Results: CFA of MSQOL-54 subscales showed that the data fitted the overall model well. Two subscales (Role Limitations-Physical, Role Limitations-Emotional) did not fit the PCM, and were removed; two other subscales (Health Perceptions, Social Function) did not fit the model, but were retained as single items. Sexual Satisfaction (single-item subscale) was also removed. The resulting MSQOL-29 consisted of 25 items grouped in 7 subscales, plus 4 single items. PCM fit statistics were within the acceptability range for all MSQOL-29 items except one which had significant DIF by age. EFA and CFA indicated adequate fit to the original two-factor (Physical and Mental Health Composites) hypothesis. Cognitive debriefing confirmed that MSQOL-29 was acceptable and had lost no key items. Conclusions: The proposed MSQOL-29 is 50% shorter than MSQOL-54, yet preserves key quality of life dimensions. Prospective validation on a large, independent MS patient sample is ongoing.

Published
2016

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