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Your search keyword '"Bigalke, Boris"' showing total 9 results
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9 results on '"Bigalke, Boris"'

1. Comprehensive multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures

Author

Engel, Leif-Christopher, primary, Landmesser, Ulf, additional, Abdelwahed, Youssef S., additional, Jaguszewski, Milosz, additional, Gigengack, Kevin, additional, Wurster, Thomas-Heinrich, additional, Skurk, Carsten, additional, Manes, Costantina, additional, Schuster, Andreas, additional, Noutsias, Michel, additional, Hamm, Bernd, additional, Botnar, Rene M., additional, Makowski, Marcus R., additional, and Bigalke, Boris, additional

Published
2020
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2. Cardiovascular magnetic resonance imaging feature tracking: Impact of training on observer performance and reproducibility

Author

Backhaus, Sören J., primary, Metschies, Georg, additional, Billing, Marcus, additional, Kowallick, Johannes T., additional, Gertz, Roman J., additional, Lapinskas, Tomas, additional, Pieske, Burkert, additional, Lotz, Joachim, additional, Bigalke, Boris, additional, Kutty, Shelby, additional, Hasenfuß, Gerd, additional, Beerbaum, Philipp, additional, Kelle, Sebastian, additional, and Schuster, Andreas, additional

Published
2019
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3. Quantification of left ventricular torsion and diastolic recoil using cardiovascular magnetic resonance myocardial feature tracking

Author

Kowallick, Johannes T., Lamata, Pablo, Hussain, Shazia T., Kutty, Shelby, Steinmetz, Michael, Sohns, Jan M., Fasshauer, Martin, Staab, Wieland, Unterberg-Buchwald, Christina, Bigalke, Boris, Lotz, Joachim, Hasenfuß, Gerd, and Schuster, Andreas

Subjects
Adult, Male, Rotation, Systole, Torsion, Mechanical, Cardiology, Magnetic Resonance Imaging, Cine, lcsh:Medicine, Ventricular Function, Left, Diagnostic Radiology, Young Adult, Diastole, Diagnostic Medicine, Cardiomyopathies, Cardiovascular imaging, Deformation, Echocardiography, Ejection fraction, Heart failure, Interpolation, Magnetic resonance, Dobutamine, Functional Magnetic Resonance Imaging, Medicine and Health Sciences, Humans, Cardiovascular Imaging, lcsh:Science, Brain Mapping, Myocardium, lcsh:R, Hemodynamics, Biology and Life Sciences, Middle Aged, Magnetic Resonance Imaging, Female, lcsh:Q, Algorithms, Research Article, Neuroscience, Ejection Fraction
Abstract

OBJECTIVES: Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach. METHODS: Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 µg·kg-1·min-1) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0% LV distance) and basal (defined as 100% LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75%), Model-2 (0-100%), Model-3 (25-100%) and Model-4 (0-75%). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values). RESULTS: Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75%) discriminated between rest and stress (Global Torsion: 2.7±1.5°cm-1, 3.6±2.0°cm-1, 5.1±2.2°cm-1, p

Published
2014

7. Green Fluorescent Protein (GFP) Color Reporter Gene Visualizes Parvovirus B19 Non-Structural Segment 1 (NS1) Transfected Endothelial Modification

Author

Wurster, Thomas, primary, Pölzelbauer, Catharina, additional, Schönberger, Tanja, additional, Paul, Angela, additional, Seizer, Peter, additional, Stellos, Konstantinos, additional, Schuster, Andreas, additional, Botnar, Rene M., additional, Gawaz, Meinrad, additional, and Bigalke, Boris, additional

Published
2012
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9. Adipocytokines and CD34+ Progenitor Cells in Alzheimer's Disease.

Author

Bigalke, Boris, Schreitmüller, Brigitte, Sopova, Kateryna, Paul, Angela, Stransky, Elke, Gawaz, Meinrad, Stellos, Konstantinos, and Laske, Christoph

Subjects
*ALZHEIMER'S disease, *ATHEROSCLEROSIS, *ADIPOKINES, *HYPERCHOLESTEREMIA, *ENZYME-linked immunosorbent assay
Abstract

Background: Alzheimer's disease (AD) and atherosclerosis share common vascular risk factors such as arterial hypertension and hypercholesterolemia. Adipocytokines and CD34+ progenitor cells are associated with the progression and prognosis of atherosclerotic diseases. Their role in AD is not adequately elucidated. Methods and Findings: In the present study, we measured in 41 patients with early AD and 37 age- and weight-matched healthy controls blood concentrations of adiponectin and leptin by enzyme linked immunoabsorbent assay and of CD34+ progenitor cells using flow cytometry. We found significantly lower plasma levels of leptin in AD patients compared with the controls, whereas plasma levels of adiponectin did not show any significant differences (AD vs. control (mean6SD): leptin:8.9±5.6 ng/mL vs.16.3±15.5 ng/mL;P = 0.038; adiponectin:18.5±18.1 μg/mL vs.16.7±8.9 mg/mL;P = 0.641). In contrast, circulating CD34+ cells were significantly upregulated in AD patients (mean absolute cell count6SD:253651 vs. 203637; P = 0.02) and showed an inverse correlation with plasma levels of leptin (r =20.248; P = 0.037). In logistic regression analysis, decreased leptin concentration (P = 0.021) and increased number of CD34+ cells (P = 0.036) were both significantly associated with the presence of AD. According to multifactorial analysis of covariance, leptin serum levels were a significant independent predictor for the number of CD34+ cells (P = 0.002). Conclusions: Our findings suggest that low plasma levels of leptin and increased numbers of CD34+ progenitor cells are both associated with AD. In addition, the results of our study provide first evidence that increased leptin plasma levels are associated with a reduced number of CD34+ progenitor cells in AD patients. These findings point towards a combined involvement of leptin and CD34+ progenitor cells in the pathogenesis of AD. Thus, plasma levels of leptin and circulating CD34+ progenitor cells could represent an important molecular link between atherosclerotic diseases and AD. Further studies should clarify the pathophysiological role of both adipocytokines and progenitor cells in AD and possible diagnostic and therapeutic applications. [ABSTRACT FROM AUTHOR]

Published
2011
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