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6 results on '"Boido, Marina"'

2. VGF Protein and Its C-Terminal Derived Peptides in Amyotrophic Lateral Sclerosis: Human and Animal Model Studies

Author

Brancia, Carla, primary, Noli, Barbara, additional, Boido, Marina, additional, Boi, Andrea, additional, Puddu, Roberta, additional, Borghero, Giuseppe, additional, Marrosu, Francesco, additional, Bongioanni, Paolo, additional, Orrù, Sandro, additional, Manconi, Barbara, additional, D’Amato, Filomena, additional, Messana, Irene, additional, Vincenzoni, Federica, additional, Vercelli, Alessandro, additional, Ferri, Gian-Luca, additional, and Cocco, Cristina, additional

Published
2016
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5. Myogenic Potential of Whole Bone Marrow Mesenchymal Stem Cells In Vitro and In Vivo for Usage in Urinary Incontinence

Author

Gunetti, Monica, primary, Tomasi, Simone, additional, Giammò, Alessandro, additional, Boido, Marina, additional, Rustichelli, Deborah, additional, Mareschi, Katia, additional, Errichiello, Edoardo, additional, Parola, Maurizio, additional, Ferrero, Ivana, additional, Fagioli, Franca, additional, Vercelli, Alessandro, additional, and Carone, Roberto, additional

Published
2012
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6. Selective Vulnerability of Spinal and Cortical Motor Neuron Subpopulations in delta7 SMA Mice

Author

Giorgio Battaglia, Marina Boido, Antonio Piras, Francesco Vagni, Denise Locatelli, Paolo d'Errico, Elena De Amicis, Valeria Valsecchi, Silvia Capra, Alessandro Vercelli, D'Errico, Paolo, Boido, Marina, Piras, Antonio, Valsecchi, Valeria, De Amicis, Elena, Locatelli, Denise, Capra, Silvia, Vagni, Francesco, Vercelli, Alessandro, and Battaglia, Giorgio

Subjects
Cholinergic Neuron, lcsh:Medicine, SMN1, Biology, Motor Neuron, Muscular Atrophy, Spinal, Mice, Motor system, medicine, Animals, Gliosis, lcsh:Science, Cerebral Cortex, Mice, Knockout, Motor Neurons, Biochemistry, Genetics and Molecular Biology (all), Multidisciplinary, Animal, Pyramidal Cells, lcsh:R, Motor Cortex, Gliosi, Spinal muscular atrophy, Anatomy, Motor neuron, SMA, medicine.disease, Spinal cord, Survival of Motor Neuron 1 Protein, Cholinergic Neurons, Disease Models, Animal, medicine.anatomical_structure, Agricultural and Biological Sciences (all), nervous system, Spinal Cord, Cerebral cortex, Pyramidal Cell, lcsh:Q, Neuroscience, Motor cortex, Research Article
Abstract

Loss of the survival motor neuron gene (SMN1) is responsible for spinal muscular atrophy (SMA), the most common inherited cause of infant mortality. Even though the SMA phenotype is traditionally considered as related to spinal motor neuron loss, it remains debated whether the specific targeting of motor neurons could represent the best therapeutic option for the disease. We here investigated, using stereological quantification methods, the spinal cord and cerebral motor cortex of ∆7 SMA mice during development, to verify extent and selectivity of motor neuron loss. We found progressive post-natal loss of spinal motor neurons, already at pre-symptomatic stages, and a higher vulnerability of motor neurons innervating proximal and axial muscles. Larger motor neurons decreased in the course of disease, either for selective loss or specific developmental impairment. We also found a selective reduction of layer V pyramidal neurons associated with layer V gliosis in the cerebral motor cortex. Our data indicate that in the ∆7 SMA model SMN loss is critical for the spinal cord, particularly for specific motor neuron pools. Neuronal loss, however, is not selective for lower motor neurons. These data further suggest that SMA pathogenesis is likely more complex than previously anticipated. The better knowledge of SMA models might be instrumental in shaping better therapeutic options for affected patients.

Published
2013

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