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1. Comparison of the SARS-CoV-2 spike protein ELISA and the Abbott Architect SARS-CoV-2 IgG nucleocapsid protein assays for detection of antibodies.

Author

Wadhwa A, Yin S, Freeman B, Hershow RB, Killerby M, Yousaf AR, Lester S, Mills L, Buono SA, Pomeroy M, Owusu D, Chu VT, Tate JE, Bhattacharyya S, Hall P, Thornburg NJ, and Kirking HL

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, COVID-19 virology, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay methods, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Sensitivity and Specificity, Young Adult, Antibodies, Viral immunology, COVID-19 diagnosis, Immunoglobulin G immunology, Nucleocapsid immunology, Nucleocapsid Proteins immunology, SARS-CoV-2 immunology, Spike Glycoprotein, Coronavirus immunology
Abstract

Serologic assays developed for SARS-CoV-2 detect different antibody subtypes and are based on different target antigens. Comparison of the performance of a SARS-CoV-2 Spike-Protein ELISA and the nucleocapsid-based Abbott ArchitectTM SARS-CoV-2 IgG assay indicated that the assays had high concordance, with rare paired discordant tests results., Competing Interests: The authors have declared that no competing interests exist.

Published
2021
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