1. Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study
- Author
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Burte, Emilie, Bousquet, Jean, Varraso, Raphaëlle, Gormand, Frédéric, Just, Jocelyne, Matran, Régis, Pin, Isabelle, Siroux, Valerie, Jacquemin, Bénédicte, Nadif, Rachel, Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Department of Pneumology [Lyon], Hospices Civils de Lyon (HCL), Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC), Université Lille Nord de France (COMUE), Team of environmental epidemiology applied to reproduction and respiratory health / IAB, INSERM, CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Pediatric department, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and HAL UPMC, Gestionnaire
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Adult ,Male ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,lcsh:R ,lcsh:Medicine ,Comorbidity ,Allergens ,Asthma ,respiratory tract diseases ,Cross-Sectional Studies ,Phenotype ,immune system diseases ,Case-Control Studies ,Surveys and Questionnaires ,Prevalence ,Humans ,Female ,lcsh:Q ,France ,Self Report ,lcsh:Science ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Rhinitis ,Research Article - Abstract
International audience; BackgroundThe classification of rhinitis in adults is missing in epidemiological studies.ObjectiveTo identify phenotypes of adult rhinitis using an unsupervised approach (data-driven) compared with a classical hypothesis-driven approach.Methods983 adults of the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) were studied. Self-reported symptoms related to rhinitis such as nasal symptoms, hay fever, sinusitis, conjunctivitis, and sensitivities to different triggers (dust, animals, hay/flowers, cold air…) were used. Allergic sensitization was defined by at least one positive skin prick test to 12 aeroallergens. Mixture model was used to cluster participants, independently in those without (Asthma-, n = 582) and with asthma (Asthma+, n = 401).ResultsThree clusters were identified in both groups: 1) Cluster A (55% in Asthma-, and 22% in Asthma+) mainly characterized by the absence of nasal symptoms, 2) Cluster B (23% in Asthma-, 36% in Asthma+) mainly characterized by nasal symptoms all over the year, sinusitis and a low prevalence of positive skin prick tests, and 3) Cluster C (22% in Asthma-, 42% in Asthma+) mainly characterized by a peak of nasal symptoms during spring, a high prevalence of positive skin prick tests and a high report of hay fever, allergic rhinitis and conjunctivitis. The highest rate of polysensitization (80%) was found in participants with comorbid asthma and allergic rhinitis.ConclusionThis cluster analysis highlighted three clusters of rhinitis with similar characteristics than those known by clinicians but differing according to allergic sensitization, and this whatever the asthma status. These clusters could be easily rebuilt using a small number of variables.
- Published
- 2015
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