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10 results on '"Cai, Xue"'

3. Congestive Heart Failure Leads to Prolongation of the PR Interval and Atrioventricular Junction Enlargement and Ion Channel Remodelling in the Rabbit

Author

Nikolaidou, Theodora, Cai, Xue J., Stephenson, Robert S., Yanni, Joseph, Lowe, Tristan, Atkinson, Andrew J., Jones, Caroline B., Sardar, Rida, Corno, Antonio F., Dobrzynski, Halina, Withers, Philip J., Jarvis, Jonathan C., Hart, George, and Boyett, Mark R.

Subjects
Heart Failure, Male, Ventricular Remodeling, Myocardium, lcsh:R, B110, lcsh:Medicine, Cardiomegaly, Atrial Remodeling, X-Ray Microtomography, Ion Channels, RC1200, Disease Models, Animal, Electrocardiography, Echocardiography, Connexin 43, cardiovascular system, Animals, lcsh:Q, RNA, Messenger, Rabbits, lcsh:Science, Research Article
Abstract

Heart failure is a major killer worldwide. Atrioventricular conduction block is common in heart failure; it is associated with worse outcomes and can lead to syncope and bradycardic death. We examine the effect of heart failure on anatomical and ion channel remodelling in the rabbit atrioventricular junction (AVJ). Heart failure was induced in New Zealand rabbits by disruption of the aortic valve and banding of the abdominal aorta resulting in volume and pressure overload. Laser micro-dissection and real-time polymerase chain reaction (RTPCR) were employed to investigate the effects of heart failure on ion channel remodelling in four regions of the rabbit AVJ and in septal tissues. Investigation of the AVJ anatomy was performed using micro-computed tomography (micro-CT). Heart failure animals developed first degree heart block. Heart failure caused ventricular myocardial volume increase with a 35% elongation of the AVJ. There was downregulation of HCN1 and Cx43 mRNA transcripts across all regions and downregulation of Cav1.3 in the transitional tissue. Cx40 mRNA was significantly downregulated in the atrial septum and AVJ tissues but not in the ventricular septum. mRNA abundance for ANP, CLCN2 and Navβ1 was increased with heart failure; Nav1.1 was increased in the inferior nodal extension/compact node area. Heart failure in the rabbit leads to prolongation of the PR interval and this is accompanied\ud by downregulation of HCN1, Cav1.3, Cx40 and Cx43 mRNAs and anatomical enlargement of the entire heart and AVJ.

Published
2015

10. The Mitochondrial Genome of Paramphistomum cervi (Digenea), the First Representative for the Family Paramphistomidae.

Author

Yan, Hong-Bin, Wang, Xing-Ye, Lou, Zhong-Zi, Li, Li, Blair, David, Yin, Hong, Cai, Jin-Zhong, Dai, Xue-Ling, Lei, Meng-Tong, Zhu, Xing-Quan, Cai, Xue-Peng, and Jia, Wan-Zhong

Subjects
PARAMPHISTOMUM, MITOCHONDRIAL DNA, NUCLEOTIDE sequence, TREMATODA, CLONORCHIS sinensis, GENETIC code, TRANSFER RNA, RIBOSOMAL RNA
Abstract

We determined the complete mitochondrial DNA (mtDNA) sequence of a fluke, Paramphistomum cervi (Digenea: Paramphistomidae). This genome (14,014 bp) is slightly larger than that of Clonorchis sinensis (13,875 bp), but smaller than those of other digenean species. The mt genome of P. cervi contains 12 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes and 2 non-coding regions (NCRs), a complement consistent with those of other digeneans. The arrangement of protein-coding and ribosomal RNA genes in the P. cervi mitochondrial genome is identical to that of other digeneans except for a group of Schistosoma species that exhibit a derived arrangement. The positions of some transfer RNA genes differ. Bayesian phylogenetic analyses, based on concatenated nucleotide sequences and amino-acid sequences of the 12 protein-coding genes, placed P. cervi within the Order Plagiorchiida, but relationships depicted within that order were not quite as expected from previous studies. The complete mtDNA sequence of P. cervi provides important genetic markers for diagnostics, ecological and evolutionary studies of digeneans. [ABSTRACT FROM AUTHOR]

Published
2013
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