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Your search keyword '"Chen, Chuan-Mu"' showing total 11 results
Start Over Author "Chen, Chuan-Mu" Journal plos one
11 results on '"Chen, Chuan-Mu"'

1. Lessening of porcine epidemic diarrhoea virus susceptibility in piglets after editing of the CMP-N-glycolylneuraminic acid hydroxylase gene with CRISPR/Cas9 to nullify N-glycolylneuraminic acid expression

Author

Tu, Ching-Fu, primary, Chuang, Chin-kai, additional, Hsiao, Kai-Hsuan, additional, Chen, Chien-Hong, additional, Chen, Chi-Min, additional, Peng, Su-Hei, additional, Su, Yu-Hsiu, additional, Chiou, Ming-Tang, additional, Yen, Chon-Ho, additional, Hung, Shao-Wen, additional, Yang, Tien-Shuh, additional, and Chen, Chuan-Mu, additional

Published
2019
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3. Interleukin-13 Inhibits Lipopolysaccharide-Induced BPIFA1 Expression in Nasal Epithelial Cells

Author

Tsou, Yung-An, primary, Lin, Chia-Der, additional, Chen, Hui-Chen, additional, Hsu, Hui-Ying, additional, Wu, Lii-Tzu, additional, Chiang-Ni, Chuan, additional, Chen, Chih-Jung, additional, Wu, Tsu-Fang, additional, Kao, Min-Chuan, additional, Chen, Yu-An, additional, Peng, Ming-Te, additional, Tsai, Ming-Hsui, additional, Chen, Chuan-Mu, additional, and Lai, Chih-Ho, additional

Published
2015
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11. Activation of IFN-γ/STAT/IRF-1 in Hepatic Responses to Klebsiella pneumoniae Infection.

Author

Lin, Yi-Chun, Lu, Min-Chi, Lin, Chingju, Chiang, Ming-Ko, Jan, Ming-Shiou, Tang, Hui-Ling, Liu, Hsu-Chung, Lin, Wea-Lung, Huang, Chih-Yang, Chen, Chuan-Mu, and Lai, Yi-Chyi

Subjects
KLEBSIELLA pneumoniae, INTERFERONS, ETIOLOGY of diseases, LIVER abscesses, DIABETES, PUBLIC health, BIOLUMINESCENCE
Abstract

Background:Klebsiella pneumoniae-caused liver abscess (KLA) has become a health problem in Taiwan and is continually reported in other countries. Diabetes mellitus, the most common metabolic disorder, underlies half of the KLA patients in Taiwan. The clinical impact of KLA has been well-documented. Nevertheless, the molecular basis regarding how K. pneumoniae causes liver infection, particularly in diabetic individuals, remains unclear. Methodology/Principle Findings:Auto-bioluminescence-expressing K. pneumoniae was inoculated into diabetic mice and age-match naïve control. With the use of invivo imaging system, translocation of the bioluminescence-expressing K. pneumoniae from intestine to extraintestinal organs, mainly the liver, was noted in 80% of the diabetic mice, whereas the same bacteria causes extraintestinal infections in only 31% of naïve mice. Besides increased morbidity, the severity of hepatic tissue injury was also enhanced in the K. pneumoniae-infected diabetic mice. Upon K. pneumoniae infection, IFN-γ production was significantly evoked in the liver. To mediate IFN-γ signal, STAT (signal transducers and activators of transcription) 1 and 3 were activated in hepatocytes, and so was the expression of IRF (interferon regulatory factor)-1. Moreover, accumulation of neutrophils which was triggered by prolonged production of IL-1β and MIP-2, and significant increases in the level of active caspase 3 and phospho-eIF2α, were exclusively revealed in the K. pneumoniae-infected diabetic mice. Conclusion:The activation of IFN-γ/STAT/IRF-1 signaling demonstrated by this work emphasizes the role of IFN-γ for mediating the hepatic response to K. pneumoniae infection. [ABSTRACT FROM AUTHOR]

Published
2013
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