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4. Correction: The Risk of Peripheral Arterial Disease after Parathyroidectomy in Patients with End-Stage Renal Disease

Author

Hsu, Yueh-Han, Yu, Hui-I, Chen, Hsuan-Ju, Li, Tsai-Chung, Hsu, Chih-Cheng, and Kao, Chia-Hung

Subjects
Adult, Aged, 80 and over, Parathyroidectomy, Multidisciplinary, Adolescent, lcsh:R, Taiwan, Correction, lcsh:Medicine, Middle Aged, Peripheral Arterial Disease, Young Adult, Renal Dialysis, Risk Factors, Humans, Kidney Failure, Chronic, Hyperparathyroidism, Secondary, lcsh:Q, lcsh:Science, Aged, Follow-Up Studies, Retrospective Studies
Abstract

The changes of the risk of peripheral arterial disease (PAD) in patients with end-stage renal disease after parathyroidectomy are scant.We used a nationwide health insurance claims database to select all dialysis-dependent patients with end-stage renal disease aged 18 years and older for the study population in 2000 to 2006. Of the patients with end-stage renal disease, we selected 947 patients who had undergone parathyroidectomy as the parathyroidectomy group and frequency matched 3746 patients with end-stage renal disease by sex, age, years since the disease diagnosis, and the year of index date as the non-parathyroidectomy group. We used a multivariate Cox proportional hazards regression analysis with the use of a robust sandwich covariance matrix estimate, accounting for the intra-cluster dependence of hospitals or clinics, to measure the risk of peripheral arterial disease for the parathyroidectomy group compared with the non-parathyroidectomy group after adjusting for sex, age, premium-based income, urbanization, and comorbidity.The mean post-op follow-up periods were 5.08 and 4.52 years for the parathyroidectomy and non-parathyroidectomy groups, respectively; the incidence density rate of PAD in the PTX group was 12.26 per 1000 person-years, significantly lower than the data in the non-PTX group (24.09 per 1000 person-years, adjusted HR = 0.66, 95% CI = 0.46-0.94).Parathyroidectomy is associated with reduced risk of peripheral arterial disease in patients with end-stage renal disease complicated with severe secondary hyperparathyroidism.

Published
2016

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