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1. Sequential monitoring of lymphocyte subsets and of T-and-B cell neogenesis indexes to identify time-varying immunologic profiles in relation to graft-versus-host disease and relapse after allogeneic stem cell transplantation.

Author

Cristina Skert, Simone Perucca, Marco Chiarini, Viviana Giustini, Alessandra Sottini, Claudia Ghidini, Stefano Martellos, Federica Cattina, Benedetta Rambaldi, Valeria Cancelli, Michele Malagola, Alessandro Turra, Nicola Polverelli, Simona Bernardi, Luisa Imberti, and Domenico Russo

Subjects
Medicine, Science
Abstract

T and B lymphocyte subsets have been not univocally associated to Graft-versus-host disease (GVHD) and relapse of hematological malignancies after stem cell transplantation (SCT). Their sequential assessment together with B and T cell neogenesis indexes has been not thoroughly analysed in relation to these changing and interrelated immunologic/clinic events yet. Lymphocyte subsets in peripheral blood (PB) and B and T cell neogenesis indexes were analysed together at different time points in a prospective study of 50 patients. Principal component analysis (PCA) was used as first step of multivariate analysis to address issues related to a high number of variables versus a relatively low number of patients. Multivariate analysis was completed by Fine-Gray proportional hazard regression model. PCA identified 3 clusters of variables (PC1-3), which correlated with acute GVHD: PC1 (pre-SCT: KRECs≥6608/ml, unswitched memory B 44%, CD8+TCM cells>4%; HR 1.9, p = 0.01), and PC3 (at aGVHD onset: CD4+TEMRA69%, switched memory CD19+ = 0 cells and KRECs

Published
2017
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2. Sequential monitoring of lymphocyte subsets and of T-and-B cell neogenesis indexes to identify time-varying immunologic profiles in relation to graft-versus-host disease and relapse after allogeneic stem cell transplantation

Author

Viviana Giustini, Michele Malagola, Nicola Polverelli, Federica Cattina, Simona Bernardi, Simone Perucca, Stefano Martellos, Marco Chiarini, Luisa Imberti, Claudia Ghidini, Alessandra Sottini, Cristina Skert, Valeria Cancelli, Alessandro Turra, Domenico Russo, Benedetta Rambaldi, Skert, Cristina, Perucca, Simone, Chiarini, Marco, Giustini, Viviana, Sottini, Alessandra, Ghidini, Claudia, Martellos, Stefano, Cattina, Federica, Rambaldi, Benedetta, Cancelli, Valeria, Malagola, Michele, Turra, Alessandro, Polverelli, Nicola, Bernardi, Simona, Imberti, Luisa, and Russo, Domenico

Subjects
Genetics and Molecular Biology (all), Male, B Cells, Cell Transplantation, T-Lymphocytes, lcsh:Medicine, Graft vs Host Disease, Medicine (all), Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Signal transduction, Biochemistry, Neogenesis, Memory T cells, Steroid Therapy, White Blood Cells, 0302 clinical medicine, Mathematical and Statistical Techniques, Animal Cells, Recurrence, Medicine and Health Sciences, Blood and Lymphatic System Procedures, Cytotoxic T cell, Lymphocytes, lcsh:Science, B-Lymphocytes, Multidisciplinary, biology, Pharmaceutics, Hematopoietic Stem Cell Transplantation, Middle Aged, Flow Cytometry, medicine.anatomical_structure, surgical procedures, operative, 030220 oncology & carcinogenesis, Physical Sciences, Female, Cellular Types, Coreceptors, Statistics (Mathematics), Research Article, Adult, Adolescent, T cell, Immune Cells, Immunology, T cells, Surgical and Invasive Medical Procedures, Cytotoxic T cells, Research and Analysis Methods, CD19, 03 medical and health sciences, Young Adult, Drug Therapy, medicine, Humans, Transplantation, Homologous, Statistical Methods, Antibody-Producing Cells, B cell, Aged, Transplantation, Blood Cells, business.industry, lcsh:R, Biology and Life Sciences, CD coreceptors, Cell Biology, biology.organism_classification, medicine.disease, Lymphocyte Subsets, Graft-versus-host disease, Multivariate Analysis, biology.protein, lcsh:Q, business, CD8, Mathematics, 030215 immunology, Stem Cell Transplantation
Abstract

T and B lymphocyte subsets have been not univocally associated to Graft-versus-host disease (GVHD) and relapse of hematological malignancies after stem cell transplantation (SCT). Their sequential assessment together with B and T cell neogenesis indexes has been not thoroughly analysed in relation to these changing and interrelated immunologic/clinic events yet. Lymphocyte subsets in peripheral blood (PB) and B and T cell neogenesis indexes were analysed together at different time points in a prospective study of 50 patients. Principal component analysis (PCA) was used as first step of multivariate analysis to address issues related to a high number of variables versus a relatively low number of patients. Multivariate analysis was completed by Fine-Gray proportional hazard regression model. PCA identified 3 clusters of variables (PC1-3), which correlated with acute GVHD: PC1 (pre-SCT: KRECs≥6608/ml, unswitched memory B 44%, CD8+TCM cells>4%; HR 1.9, p = 0.01), and PC3 (at aGVHD onset: CD4+TEMRA69%, switched memory CD19+ = 0 cells and KRECs

Published
2017

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