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2 results on '"Cynthia Callahan"'

1. Risk factors for and prediction of post-intubation hypotension in critically ill adults: A multicenter prospective cohort study.

Author

Nathan J Smischney, Rahul Kashyap, Ashish K Khanna, Ernesto Brauer, Lee E Morrow, Mohamed O Seisa, Darrell R Schroeder, Daniel A Diedrich, Ashley Montgomery, Pablo Moreno Franco, Uchenna R Ofoma, David A Kaufman, Ayan Sen, Cynthia Callahan, Chakradhar Venkata, Gozde Demiralp, Rudy Tedja, Sarah Lee, Mariya Geube, Santhi I Kumar, Peter Morris, Vikas Bansal, Salim Surani, and SCCM Discovery (Critical Care Research Network of Critical Care Medicine) HEMAIR Investigators Consortium

Subjects
Medicine, Science
Abstract

ObjectiveHypotension following endotracheal intubation in the ICU is associated with poor outcomes. There is no formal prediction tool to help estimate the onset of this hemodynamic compromise. Our objective was to derive and validate a prediction model for immediate hypotension following endotracheal intubation.MethodsA multicenter, prospective, cohort study enrolling 934 adults who underwent endotracheal intubation across 16 medical/surgical ICUs in the United States from July 2015-January 2017 was conducted to derive and validate a prediction model for immediate hypotension following endotracheal intubation. We defined hypotension as: 1) mean arterial pressure ResultsPost-intubation hypotension developed in 344 (36.8%) patients. In the full cohort, 11 variables were independently associated with hypotension: increasing illness severity; increasing age; sepsis diagnosis; endotracheal intubation in the setting of cardiac arrest, mean arterial pressure ConclusionsA novel multivariable risk score predicted post-intubation hypotension with accuracy in both unstable and stable critically ill patients.Study registrationClinicaltrials.gov identifier: NCT02508948 and Registered Report Identifier: RR2-10.2196/11101.

Published
2020
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2. Risk factors for and prediction of post-intubation hypotension in critically ill adults: A multicenter prospective cohort study

Author

Mariya Geube, Pablo Moreno Franco, Ashish Khanna, Gozde Demiralp, Darrell R. Schroeder, David A. Kaufman, Vikas Bansal, Ashley A. Montgomery, Ernesto Brauer, Lee E. Morrow, Chakradhar Venkata, Ayan Sen, Santhi Iyer Kumar, Peter E. Morris, Sarah Lee, Daniel A. Diedrich, Rahul Kashyap, Mohamed O. Seisa, Uchenna R. Ofoma, Salim Surani, Rudy Tedja, Nathan J. Smischney, and Cynthia Callahan

Subjects
Male, Critical Care and Emergency Medicine, Pulmonology, Epidemiology, medicine.medical_treatment, Blood Pressure, Cardiovascular Medicine, Vascular Medicine, Cohort Studies, 0302 clinical medicine, Medical Conditions, Medicine and Health Sciences, Cardiac Arrest, Medicine, Intubation, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Aged, 80 and over, Multidisciplinary, Middle Aged, Hospitals, Intensive Care Units, Cardiovascular Diseases, Anesthesia, Cohort, Female, Hypotension, Cohort study, medicine.drug, Research Article, Adult, Mean arterial pressure, Science, Critical Illness, Cardiology, Surgical and Invasive Medical Procedures, Models, Biological, 03 medical and health sciences, Respiratory Disorders, Respiratory Failure, Etomidate, Intubation, Intratracheal, Humans, Aged, business.industry, 030208 emergency & critical care medicine, Cardiovascular Disease Risk, Health Care, Blood pressure, Respiratory failure, Health Care Facilities, Medical Risk Factors, business
Abstract

ObjectiveHypotension following endotracheal intubation in the ICU is associated with poor outcomes. There is no formal prediction tool to help estimate the onset of this hemodynamic compromise. Our objective was to derive and validate a prediction model for immediate hypotension following endotracheal intubation.MethodsA multicenter, prospective, cohort study enrolling 934 adults who underwent endotracheal intubation across 16 medical/surgical ICUs in the United States from July 2015-January 2017 was conducted to derive and validate a prediction model for immediate hypotension following endotracheal intubation. We defined hypotension as: 1) mean arterial pressure ResultsPost-intubation hypotension developed in 344 (36.8%) patients. In the full cohort, 11 variables were independently associated with hypotension: increasing illness severity; increasing age; sepsis diagnosis; endotracheal intubation in the setting of cardiac arrest, mean arterial pressure ConclusionsA novel multivariable risk score predicted post-intubation hypotension with accuracy in both unstable and stable critically ill patients.Study registrationClinicaltrials.gov identifier: NCT02508948 and Registered Report Identifier: RR2-10.2196/11101.

Published
2020

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