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5 results on '"Farsetti, Antonella"'

1. Estrogen-Dependent Dynamic Profile of eNOS-DNA Associations in Prostate Cancer

Author

Nanni, Simona, primary, Aiello, Aurora, additional, Re, Agnese, additional, Guffanti, Alessandro, additional, Benvenuti, Valentina, additional, Colussi, Claudia, additional, Castro-Vega, Luis Jaime, additional, Felsani, Armando, additional, Londono-Vallejo, Arturo, additional, Capogrossi, Maurizio C., additional, Bacchetti, Silvia, additional, Gaetano, Carlo, additional, Pontecorvi, Alfredo, additional, and Farsetti, Antonella, additional

Published
2013
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2. In Vitro Epigenetic Reprogramming of Human Cardiac Mesenchymal Stromal Cells into Functionally Competent Cardiovascular Precursors

Author

Vecellio, Matteo, primary, Meraviglia, Viviana, additional, Nanni, Simona, additional, Barbuti, Andrea, additional, Scavone, Angela, additional, DiFrancesco, Dario, additional, Farsetti, Antonella, additional, Pompilio, Giulio, additional, Colombo, Gualtiero I., additional, Capogrossi, Maurizio C., additional, Gaetano, Carlo, additional, and Rossini, Alessandra, additional

Published
2012
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3. Histone Deacetylase Inhibition Enhances Self Renewal and Cardioprotection by Human Cord Blood-Derived CD34+ Cells

Author

Burba, Ilaria, primary, Colombo, Gualtiero I., additional, Staszewsky, Lidia Irene, additional, De Simone, Marco, additional, Devanna, Paolo, additional, Nanni, Simona, additional, Avitabile, Daniele, additional, Molla, Fabiola, additional, Cosentino, Simona, additional, Russo, Ilaria, additional, De Angelis, Noeleen, additional, Soldo, Annarita, additional, Biondi, Antonella, additional, Gambini, Elisa, additional, Gaetano, Carlo, additional, Farsetti, Antonella, additional, Pompilio, Giulio, additional, Latini, Roberto, additional, Capogrossi, Maurizio C., additional, and Pesce, Maurizio, additional

Published
2011
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4. Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo

Author

Nardinocchi, Lavinia, primary, Pantisano, Valentina, additional, Puca, Rosa, additional, Porru, Manuela, additional, Aiello, Aurora, additional, Grasselli, Annalisa, additional, Leonetti, Carlo, additional, Safran, Michal, additional, Rechavi, Gideon, additional, Givol, David, additional, Farsetti, Antonella, additional, and D'Orazi, Gabriella, additional

Published
2010
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5. Histone Deacetylase Inhibition Enhances Self Renewal and Cardioprotection by Human Cord Blood-Derived CD34+ Cells.

Author

Burba, Ilaria, Colombo, Gualtiero I., Staszewsky, Lidia Irene, De Simone, Marco, Devanna, Paolo, Nanni, Simona, Avitabile, Daniele, Molla, Fabiola, Cosentino, Simona, Russo, Ilaria, De Angelis, Noeleen, Soldo, Annarita, Biondi, Antonella, Gambini, Elisa, Gaetano, Carlo, Farsetti, Antonella, Pompilio, Giulio, Latini, Roberto, Capogrossi, Maurizio C., and Pesce, Maurizio

Subjects
HISTONE deacetylase, CORD blood, CD34 antigen, PROGENITOR cells, CORONARY disease, VALPROIC acid, GENE expression, MYOCARDIAL infarction, LABORATORY mice
Abstract

Background: Use of peripheral blood- or bone marrow-derived progenitors for ischemic heart repair is a feasible option to induce neo-vascularization in ischemic tissues. These cells, named Endothelial Progenitors Cells (EPCs), have been extensively characterized phenotypically and functionally. The clinical efficacy of cardiac repair by EPCs cells remains, however, limited, due to cell autonomous defects as a consequence of risk factors. The devise of ''enhancement'' strategies has been therefore sought to improve repair ability of these cells and increase the clinical benefit. Principal Findings: Pharmacologic inhibition of histone deacetylases (HDACs) is known to enhance hematopoietic stem cells engraftment by improvement of self renewal and inhibition of differentiation in the presence of mitogenic stimuli in vitro. In the present study cord blood-derived CD34+ were pre-conditioned with the HDAC inhibitor Valproic Acid. This treatment affected stem cell growth and gene expression, and improved ischemic myocardium protection in an immunodeficient mouse model of myocardial infarction. Conclusions: Our results show that HDAC blockade leads to phenotype changes in CD34+ cells with enhanced self renewal and cardioprotection. [ABSTRACT FROM AUTHOR]

Published
2011
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