36 results on '"Furey A"'
Search Results
2. The queen bee phenomenon in Canadian surgical subspecialties: An evaluation of gender biases in the resident training environment
- Author
-
Goff, Lydia, primary, Greene, Helena, additional, Munn, Alexandra, additional, Furey, Andrew, additional, and Smith, Nicholas, additional
- Published
- 2024
- Full Text
- View/download PDF
3. Evaluating water quality impacts on visitation to coastal recreation areas using data derived from cell phone locations.
- Author
-
Ryan P Furey, Nathaniel H Merrill, Josh P Sawyer, Kate K Mulvaney, and Marisa J Mazzotta
- Subjects
Medicine ,Science - Abstract
Linking human behavior to environmental quality is critical for effective natural resource management. While it is commonly assumed that environmental conditions partially explain variation in visitation to coastal recreation areas across space and time, scarce and inconsistent visitation observations challenge our ability to reveal these connections. With the ubiquity of mobile phone usage, novel sources of digitally derived data are increasingly available at a massive scale. Applications of mobile phone locational data have been effective in research on urban-centric human mobility and transportation, but little work has been conducted on understanding behavioral patterns surrounding dynamic natural resources. We present an application of cell phone locational data to estimate the effects of beach closures, based on measured bacteria threshold exceedances, on visitation to coastal access points. Our results indicate that beach closures on Cape Cod, MA, USA have a significant negative effect on visitation at those beaches with closures, while closures at a sample of coastal access points elsewhere in New England have no detected impact on visitation. Our findings represent geographic mobility patterns for over 7 million unique coastal visits and suggest that closures resulted in approximately 1,800 (0.026%) displaced visits for Cape Cod during the summer season of 2017. We demonstrate the potential for human-mobility data derived from mobile phones to reveal the scale of use and behavior in response to changes in dynamic natural resources. Potential future applications of passively collected geocoded data to human-environmental systems are vast.
- Published
- 2022
- Full Text
- View/download PDF
4. A classification modeling approach for determining metabolite signatures in osteoarthritis.
- Author
-
Jason S Rockel, Weidong Zhang, Konstantin Shestopaloff, Sergei Likhodii, Guang Sun, Andrew Furey, Edward Randell, Kala Sundararajan, Rajiv Gandhi, Guangju Zhai, and Mohit Kapoor
- Subjects
Medicine ,Science - Abstract
Multiple factors can help predict knee osteoarthritis (OA) patients from healthy individuals, including age, sex, and BMI, and possibly metabolite levels. Using plasma from individuals with primary OA undergoing total knee replacement and healthy volunteers, we measured lysophosphatidylcholine (lysoPC) and phosphatidylcholine (PC) analogues by metabolomics. Populations were stratified on demographic factors and lysoPC and PC analogue signatures were determined by univariate receiver-operator curve (AUC) analysis. Using signatures, multivariate classification modeling was performed using various algorithms to select the most consistent method as measured by AUC differences between resampled training and test sets. Lists of metabolites indicative of OA [AUC > 0.5] were identified for each stratum. The signature from males age > 50 years old encompassed the majority of identified metabolites, suggesting lysoPCs and PCs are dominant indicators of OA in older males. Principal component regression with logistic regression was the most consistent multivariate classification algorithm tested. Using this algorithm, classification of older males had fair power to classify OA patients from healthy individuals. Thus, individual levels of lysoPC and PC analogues may be indicative of individuals with OA in older populations, particularly males. Our metabolite signature modeling method is likely to increase classification power in validation cohorts.
- Published
- 2018
- Full Text
- View/download PDF
5. Insectivorous bat reproduction and human cave visitation in Cambodia: A perfect conservation storm?
- Author
-
Thona Lim, Julien Cappelle, Thavry Hoem, and Neil Furey
- Subjects
Medicine ,Science - Abstract
Cave roosting bats represent an important component of Southeast Asian bat diversity and are vulnerable to human disturbance during critical reproductive periods (pregnancy, lactation and weaning). Because dramatic growth of cave tourism in recent decades has raised concerns about impacts on cave bats in the region, we assessed the reproductive phenology of two insectivorous species (Hipposideros larvatus sensu lato and Taphozous melanopogon) at three caves in Cambodia for 23 months in 2014-2016 and evaluated human visitation to these sites between 2007 and 2014. Despite the differing foraging strategies employed by the two taxa, the temporal consistency observed in proportions of pregnant, lactating and juvenile bats indicates that their major birth peaks coincide with the time of greatest cave visitation annually, particularly for domestic visitors and namely during the Cambodian new year in April. They also reflect rainfall patterns and correspond with the reproductive phenology of insectivorous cave bats in Vietnam. These findings were predictable because 1) insect biomass and thus food availability for insectivorous bats are optimal for ensuring survival of young following this period, and 2) the Khmer new year is the most significant month for religious ceremonies and thus domestic cave visitation nationally, due to the abundance of Buddhist shrines and temples in Cambodian caves. While the impact of visitor disturbance on bat population recruitment cannot be empirically assessed due to lack of historical data, it is nonetheless likely to have been considerable and raises a conservation concern. Further, because growing evidence suggests that insectivorous cave bats exhibit reproductive synchrony across continental Southeast Asia where countless cave shrines are heavily frequented during April in Theravada Buddhist countries (e.g., Myanmar, Thailand, Cambodia and Laos), our results may have wider applicability in the region. We consequently advocate for increased emphasis on sustainable cave management practices in Cambodia and further investigations to determine whether our findings present a broader concern for cave bat conservation in Southeast Asia.
- Published
- 2018
- Full Text
- View/download PDF
6. Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes.
- Author
-
Weidong Zhang, Edward W Randell, Guang Sun, Sergei Likhodii, Ming Liu, Andrew Furey, and Guangju Zhai
- Subjects
Medicine ,Science - Abstract
To test whether type 2 diabetic patients have an elevated level of advanced glycation end-products (AGEs) and responsible for altered phosphatidylcholine metabolism, which we recently found to be associated with osteoarthritis (OA) and diabetes mellitus (DM), synovial fluid (SF) and plasma samples were collected from OA patients with and without DM. Hyperglycemia-related AGEs including methylglyoxal (MG), free methylglyoxal-derived hydroimidazolone (MG-H1), and protein bound N-(Carboxymethyl)lysine (CML) and N-(Carboxyethyl)lysine (CEL) levels were measured in both SF and plasma samples using liquid chromatography coupled tandem mass spectrometry methodology. The correlation between these AGEs and phosphatidylcholine acyl-alkyl C34:3 (PC ae C34:3) and C36:3 (PC ae C36:3) were examined. Eighty four patients with knee OA, including 46 with DM and 38 without DM, were included in the study. There was no significant difference in plasma levels of MG, MG-H1, CML, and CEL between OA patients with and without DM. However, the levels of MG and MG-H1, but not CML and CEL in SF were significantly higher in OA patients with DM than in those without (all p ≤0.04). This association strengthened after adjustment for age, body mass index (BMI), sex and hexose level (p
- Published
- 2017
- Full Text
- View/download PDF
7. A nonrandomized trial of vitamin D supplementation for Barrett's esophagus.
- Author
-
Linda C Cummings, Prashanthi N Thota, Joseph E Willis, Yanwen Chen, Gregory S Cooper, Nancy Furey, Beth Bednarchik, Bronia M Alashkar, John Dumot, Ashley L Faulx, Stephen P Fink, Adam M Kresak, Basel Abusneineh, Jill Barnholtz-Sloan, Patrick Leahy, Martina L Veigl, Amitabh Chak, and Sanford D Markowitz
- Subjects
Medicine ,Science - Abstract
Vitamin D deficiency may increase esophageal cancer risk. Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH) in other cancers. This nonrandomized interventional study assessed effects of vitamin D supplementation in Barrett's esophagus (BE). We hypothesized that vitamin D supplementation may have beneficial effects on gene expression including 15-PGDH in BE.BE subjects with low grade or no dysplasia received vitamin D3 (cholecalciferol) 50,000 international units weekly plus a proton pump inhibitor for 12 weeks. Esophageal biopsies from normal plus metaplastic BE epithelium and blood samples were obtained before and after vitamin D supplementation. Serum 25-hydroxyvitamin D was measured to characterize vitamin D status. Esophageal gene expression was assessed using microarrays.18 study subjects were evaluated. The baseline mean serum 25-hydroxyvitamin D level was 27 ng/mL (normal ≥30 ng/mL). After vitamin D supplementation, 25-hydroxyvitamin D levels rose significantly (median increase of 31.6 ng/mL, p
- Published
- 2017
- Full Text
- View/download PDF
8. Evaluating water quality impacts on visitation to coastal recreation areas using data derived from cell phone locations
- Author
-
Furey, Ryan P., primary, Merrill, Nathaniel H., additional, Sawyer, Josh P., additional, Mulvaney, Kate K., additional, and Mazzotta, Marisa J., additional
- Published
- 2022
- Full Text
- View/download PDF
9. Variability in Migration Routes Influences Early Marine Survival of Juvenile Salmon Smolts.
- Author
-
Nathan B Furey, Stephen P Vincent, Scott G Hinch, and David W Welch
- Subjects
Medicine ,Science - Abstract
Variability in animal migratory behavior is expected to influence fitness, but few empirical examples demonstrating this relationship exist. The initial marine phase in the migration of juvenile salmon smolts has been identified as a potentially critical life history stage to overall population productivity, yet how fine-scale migration routes may influence survival are unknown. Large-scale acoustic telemetry studies have estimated survival rates of outmigrant Pacific salmon smolts through the Strait of Georgia (SOG) along the British Columbian coastline to the Pacific Ocean, but these data have not been used to identify and characterize fine-scale movements. Data collected on over 850 sockeye salmon (Oncorhynchus nerka) and steelhead (Oncorhynchus mykiss) smolts detected at an array in the Strait of Georgia in 2004-2008 and 2010-2013 were analyzed to characterize migration routes and link movements to subsequent survival at an array 250 km further along the marine migration pathway. Both species exhibited disproportionate use of the most eastern route in the Strait of Georgia (Malaspina Strait). While many smolts moved across the northern Strait of Georgia acoustic array with no indication of long-term milling or large-scale east-to-west movements, large proportions (20-40% of sockeye and 30-50% of steelhead) exhibited a different behavior, apparently moving in a westward or counterclockwise pattern. Variability in migratory behavior for both species was linked to subsequent survival through the Strait of Georgia. Survival for both species was influenced by initial east-to-west location, and sockeye were further influenced by migration timing and duration of time spent near the northern Strait of Georgia array. Westward movements result in a net transport of smolts from Malaspina Strait to the Strait of Georgia, particularly for steelhead. Counterclockwise movements may be due to the currents in this area during the time of outmigration, and the higher proportion of steelhead smolts exhibiting this counterclockwise behavior may reflect a greater exposure to wind-altered currents for the more surface-oriented steelhead. Our results provide an empirical example of how movements can affect migration survival, for which examples remain rare in movement ecology, confirming that variability in movements themselves are an important part of the migratory process.
- Published
- 2015
- Full Text
- View/download PDF
10. SMAD3 is associated with the total burden of radiographic osteoarthritis: the Chingford study.
- Author
-
Erfan Aref-Eshghi, Yuhua Zhang, Deborah Hart, Ana M Valdes, Andrew Furey, Glynn Martin, Guang Sun, Proton Rahman, Nigel Arden, Tim D Spector, and Guangju Zhai
- Subjects
Medicine ,Science - Abstract
A newly-described syndrome called Aneurysm-Osteoarthritis Syndrome (AOS) was recently reported. AOS presents with early onset osteoarthritis (OA) in multiple joints, together with aneurysms in major arteries, and is caused by rare mutations in SMAD3. Because of the similarity of AOS to idiopathic generalized OA (GOA), we hypothesized that SMAD3 is also associated with GOA and tested the hypothesis in a population-based cohort.Study participants were derived from the Chingford study. Kellgren-Lawrence (KL) grades and the individual features of osteophytes and joint space narrowing (JSN) were scored from radiographs of hands, knees, hips, and lumbar spines. The total KL score, osteophyte score, and JSN score were calculated and used as indicators of the total burden of radiographic OA. Forty-one common SNPs within SMAD3 were genotyped using the Illumina HumanHap610Q array. Linear regression modelling was used to test the association between the total KL score, osteophyte score, and JSN score and each of the 41 SNPs, with adjustment for patient age and BMI. Permutation testing was used to control the false positive rate.A total of 609 individuals were included in the analysis. All were Caucasian females with a mean age of 60.9±5.8. We found that rs3825977, with a minor allele (T) frequency of 20%, in the last intron of SMAD3, was significantly associated with total KL score (β = 0.14, Ppermutation = 0.002). This association was stronger for the total JSN score (β = 0.19, Ppermutation = 0.002) than for total osteophyte score (β = 0.11, Ppermutation = 0.02). The T allele is associated with a 1.47-fold increased odds for people with 5 or more joints to be affected by radiographic OA (Ppermutation = 0.046).We found that SMAD3 is significantly associated with the total burden of radiographic OA. Further studies are required to reveal the mechanism of the association.
- Published
- 2014
- Full Text
- View/download PDF
11. Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma.
- Author
-
Matthew Wortham, Changcun Guo, Monica Zhang, Lingyun Song, Bum-Kyu Lee, Vishwanath R Iyer, Terrence S Furey, Gregory E Crawford, Hai Yan, and Yiping He
- Subjects
Medicine ,Science - Abstract
Despite an emerging understanding of the genetic alterations giving rise to various tumors, the mechanisms whereby most oncogenes are overexpressed remain unclear. Here we have utilized an integrated approach of genomewide regulatory element mapping via DNase-seq followed by conventional reporter assays and transcription factor binding site discovery to characterize the transcriptional regulation of the medulloblastoma oncogene Orthodenticle Homeobox 2 (OTX2). Through these studies we have revealed that OTX2 is differentially regulated in medulloblastoma at the level of chromatin accessibility, which is in part mediated by DNA methylation. In cell lines exhibiting chromatin accessibility of OTX2 regulatory regions, we found that autoregulation maintains OTX2 expression. Comparison of medulloblastoma regulatory elements with those of the developing brain reveals that these tumors engage a developmental regulatory program to drive OTX2 transcription. Finally, we have identified a transcriptional regulatory element mediating retinoid-induced OTX2 repression in these tumors. This work characterizes for the first time the mechanisms of OTX2 overexpression in medulloblastoma. Furthermore, this study establishes proof of principle for applying ENCODE datasets towards the characterization of upstream trans-acting factors mediating expression of individual genes.
- Published
- 2014
- Full Text
- View/download PDF
12. Evaluating water quality impacts on visitation to coastal recreation areas using data derived from cell phone locations
- Author
-
Ryan P. Furey, Nathaniel H. Merrill, Josh P. Sawyer, Kate K. Mulvaney, and Marisa J. Mazzotta
- Subjects
Multidisciplinary ,Bacteria ,Natural Resources ,Water Quality ,Humans ,Recreation ,Cell Phone - Abstract
Linking human behavior to environmental quality is critical for effective natural resource management. While it is commonly assumed that environmental conditions partially explain variation in visitation to coastal recreation areas across space and time, scarce and inconsistent visitation observations challenge our ability to reveal these connections. With the ubiquity of mobile phone usage, novel sources of digitally derived data are increasingly available at a massive scale. Applications of mobile phone locational data have been effective in research on urban-centric human mobility and transportation, but little work has been conducted on understanding behavioral patterns surrounding dynamic natural resources. We present an application of cell phone locational data to estimate the effects of beach closures, based on measured bacteria threshold exceedances, on visitation to coastal access points. Our results indicate that beach closures on Cape Cod, MA, USA have a significant negative effect on visitation at those beaches with closures, while closures at a sample of coastal access points elsewhere in New England have no detected impact on visitation. Our findings represent geographic mobility patterns for over 7 million unique coastal visits and suggest that closures resulted in approximately 1,800 (0.026%) displaced visits for Cape Cod during the summer season of 2017. We demonstrate the potential for human-mobility data derived from mobile phones to reveal the scale of use and behavior in response to changes in dynamic natural resources. Potential future applications of passively collected geocoded data to human-environmental systems are vast.
- Published
- 2021
13. Correction: A Predictive Framework for Integrating Disparate Genomic Data Types Using Sample-Specific Gene Set Enrichment Analysis and Multi-Task Learning.
- Author
-
Brian D. Bennett, Qing Xiong, Sayan Mukherjee, and Terrence S. Furey
- Subjects
Medicine ,Science - Published
- 2013
- Full Text
- View/download PDF
14. The extended functional neuroanatomy of emotional processing biases for masked faces in major depressive disorder.
- Author
-
Teresa A Victor, Maura L Furey, Stephen J Fromm, Patrick S F Bellgowan, Arne Öhman, and Wayne C Drevets
- Subjects
Medicine ,Science - Abstract
Major depressive disorder (MDD) is associated with a mood-congruent processing bias in the amygdala toward face stimuli portraying sad expressions that is evident even when such stimuli are presented below the level of conscious awareness. The extended functional anatomical network that maintains this response bias has not been established, however.To identify neural network differences in the hemodynamic response to implicitly presented facial expressions between depressed and healthy control participants.Unmedicated-depressed participants with MDD (n=22) and healthy controls (HC; n=25) underwent functional MRI as they viewed face stimuli showing sad, happy or neutral face expressions, presented using a backward masking design. The blood-oxygen-level dependent (BOLD) signal was measured to identify regions where the hemodynamic response to the emotionally valenced stimuli differed between groups.The MDD subjects showed greater BOLD responses than the controls to masked-sad versus masked-happy faces in the hippocampus, amygdala and anterior inferotemporal cortex. While viewing both masked-sad and masked-happy faces relative to masked-neutral faces, the depressed subjects showed greater hemodynamic responses than the controls in a network that included the medial and orbital prefrontal cortices and anterior temporal cortex.Depressed and healthy participants showed distinct hemodynamic responses to masked-sad and masked-happy faces in neural circuits known to support the processing of emotionally valenced stimuli and to integrate the sensory and visceromotor aspects of emotional behavior. Altered function within these networks in MDD may establish and maintain illness-associated differences in the salience of sensory/social stimuli, such that attention is biased toward negative and away from positive stimuli.
- Published
- 2012
- Full Text
- View/download PDF
15. A predictive framework for integrating disparate genomic data types using sample-specific gene set enrichment analysis and multi-task learning.
- Author
-
Brian D Bennett, Qing Xiong, Sayan Mukherjee, and Terrence S Furey
- Subjects
Medicine ,Science - Abstract
Understanding the root molecular and genetic causes driving complex traits is a fundamental challenge in genomics and genetics. Numerous studies have used variation in gene expression to understand complex traits, but the underlying genomic variation that contributes to these expression changes is not well understood. In this study, we developed a framework to integrate gene expression and genotype data to identify biological differences between samples from opposing complex trait classes that are driven by expression changes and genotypic variation. This framework utilizes pathway analysis and multi-task learning to build a predictive model and discover pathways relevant to the complex trait of interest. We simulated expression and genotype data to test the predictive ability of our framework and to measure how well it uncovered pathways with genes both differentially expressed and genetically associated with a complex trait. We found that the predictive performance of the multi-task model was comparable to other similar methods. Also, methods like multi-task learning that considered enrichment analysis scores from both data sets found pathways with both genetic and expression differences related to the phenotype. We used our framework to analyze differences between estrogen receptor (ER) positive and negative breast cancer samples. An analysis of the top 15 gene sets from the multi-task model showed they were all related to estrogen, steroids, cell signaling, or the cell cycle. Although our study suggests that multi-task learning does not enhance predictive accuracy, the models generated by our framework do provide valuable biological pathway knowledge for complex traits.
- Published
- 2012
- Full Text
- View/download PDF
16. Distribution and habitat associations of billfish and swordfish larvae across mesoscale features in the Gulf of Mexico.
- Author
-
Jay R Rooker, Jeff R Simms, R J David Wells, Scott A Holt, G Joan Holt, John E Graves, and Nathan B Furey
- Subjects
Medicine ,Science - Abstract
Ichthyoplankton surveys were conducted in surface waters of the northern Gulf of Mexico (NGoM) over a three-year period (2006-2008) to determine the relative value of this region as early life habitat of sailfish (Istiophorus platypterus), blue marlin (Makaira nigricans), white marlin (Kajikia albida), and swordfish (Xiphias gladius). Sailfish were the dominant billfish collected in summer surveys, and larvae were present at 37.5% of the stations sampled. Blue marlin and white marlin larvae were present at 25.0% and 4.6% of the stations sampled, respectively, while swordfish occurred at 17.2% of the stations. Areas of peak production were detected and maximum density estimates for sailfish (22.09 larvae 1000 m(-2)) were significantly higher than the three other species: blue marlin (9.62 larvae 1000 m(-2)), white marlin (5.44 larvae 1000 m(-2)), and swordfish (4.67 larvae 1000 m(-2)). The distribution and abundance of billfish and swordfish larvae varied spatially and temporally, and several environmental variables (sea surface temperature, salinity, sea surface height, distance to the Loop Current, current velocity, water depth, and Sargassum biomass) were deemed to be influential variables in generalized additive models (GAMs). Mesoscale features in the NGoM affected the distribution and abundance of billfish and swordfish larvae, with densities typically higher in frontal zones or areas proximal to the Loop Current. Habitat suitability of all four species was strongly linked to physicochemical attributes of the water masses they inhabited, and observed abundance was higher in slope waters with lower sea surface temperature and higher salinity. Our results highlight the value of the NGoM as early life habitat of billfishes and swordfish, and represent valuable baseline data for evaluating anthropogenic effects (i.e., Deepwater Horizon oil spill) on the Atlantic billfish and swordfish populations.
- Published
- 2012
- Full Text
- View/download PDF
17. A classification modeling approach for determining metabolite signatures in osteoarthritis
- Author
-
Weidong Zhang, Guang Sun, K. Shestopaloff, Sergei Likhodii, Mohit Kapoor, Rajiv Gandhi, Andrew Furey, Kala Sundararajan, Edward Randell, Jason S. Rockel, and Guangju Zhai
- Subjects
0301 basic medicine ,Oncology ,Male ,Physiology ,Metabolite ,Knees ,Primary OA ,lcsh:Medicine ,Osteoarthritis ,Logistic regression ,Biochemistry ,Body Mass Index ,Cohort Studies ,chemistry.chemical_compound ,0302 clinical medicine ,Mathematical and Statistical Techniques ,Endocrinology ,Drug Metabolism ,Metabolites ,Medicine and Health Sciences ,lcsh:Science ,Arthroplasty, Replacement, Knee ,Musculoskeletal System ,Multidisciplinary ,Middle Aged ,Osteoarthritis, Knee ,Physiological Parameters ,Physical Sciences ,Legs ,Female ,Anatomy ,Statistics (Mathematics) ,Cohort study ,Research Article ,medicine.medical_specialty ,Endocrine Disorders ,Total knee replacement ,Surgical and Invasive Medical Procedures ,Research and Analysis Methods ,Models, Biological ,03 medical and health sciences ,Musculoskeletal System Procedures ,Rheumatology ,Internal medicine ,medicine ,Diabetes Mellitus ,Humans ,Metabolomics ,Pharmacokinetics ,Statistical Methods ,030203 arthritis & rheumatology ,Pharmacology ,Joint Replacement Surgery ,business.industry ,Arthritis ,lcsh:R ,Body Weight ,Limbs (Anatomy) ,Univariate ,Biology and Life Sciences ,medicine.disease ,030104 developmental biology ,Metabolism ,chemistry ,Metabolic Disorders ,lcsh:Q ,business ,Body mass index ,Biomarkers ,Mathematics ,Forecasting - Abstract
Multiple factors can help predict knee osteoarthritis (OA) patients from healthy individuals, including age, sex, and BMI, and possibly metabolite levels. Using plasma from individuals with primary OA undergoing total knee replacement and healthy volunteers, we measured lysophosphatidylcholine (lysoPC) and phosphatidylcholine (PC) analogues by metabolomics. Populations were stratified on demographic factors and lysoPC and PC analogue signatures were determined by univariate receiver-operator curve (AUC) analysis. Using signatures, multivariate classification modeling was performed using various algorithms to select the most consistent method as measured by AUC differences between resampled training and test sets. Lists of metabolites indicative of OA [AUC > 0.5] were identified for each stratum. The signature from males age > 50 years old encompassed the majority of identified metabolites, suggesting lysoPCs and PCs are dominant indicators of OA in older males. Principal component regression with logistic regression was the most consistent multivariate classification algorithm tested. Using this algorithm, classification of older males had fair power to classify OA patients from healthy individuals. Thus, individual levels of lysoPC and PC analogues may be indicative of individuals with OA in older populations, particularly males. Our metabolite signature modeling method is likely to increase classification power in validation cohorts.
- Published
- 2017
18. Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes
- Author
-
Edward Randell, Guang Sun, M. Liu, Guangju Zhai, Andrew Furey, Sergei Likhodii, and Weidong Zhang
- Subjects
0301 basic medicine ,Glycation End Products, Advanced ,Male ,Physiology ,lcsh:Medicine ,Type 2 diabetes ,Biochemistry ,chemistry.chemical_compound ,Oxidative Damage ,Endocrinology ,Glycation ,Tandem Mass Spectrometry ,Blood plasma ,Synovial Fluid ,Medicine and Health Sciences ,Post-Translational Modification ,lcsh:Science ,2. Zero hunger ,Multidisciplinary ,Organic Compounds ,Methylglyoxal ,Monosaccharides ,Middle Aged ,Blood proteins ,Lipids ,3. Good health ,Body Fluids ,Chemistry ,Blood ,Physical Sciences ,Phosphatidylcholines ,Female ,Anatomy ,Research Article ,medicine.medical_specialty ,Endocrine Disorders ,Carbohydrates ,Blood Plasma ,03 medical and health sciences ,Rheumatology ,Diabetes mellitus ,Internal medicine ,Osteoarthritis ,medicine ,Diabetes Mellitus ,Synovial fluid ,Humans ,Hexoses ,Aged ,Plasma Proteins ,business.industry ,Arthritis ,Lysine ,lcsh:R ,Organic Chemistry ,Chemical Compounds ,Biology and Life Sciences ,Proteins ,medicine.disease ,030104 developmental biology ,chemistry ,Diabetes Mellitus, Type 2 ,Metabolic Disorders ,Hyperglycemia ,lcsh:Q ,Lipid Peroxidation ,business ,Reactive Oxygen Species ,Body mass index ,Biomarkers ,Chromatography, Liquid - Abstract
To test whether type 2 diabetic patients have an elevated level of advanced glycation end-products (AGEs) and responsible for altered phosphatidylcholine metabolism, which we recently found to be associated with osteoarthritis (OA) and diabetes mellitus (DM), synovial fluid (SF) and plasma samples were collected from OA patients with and without DM. Hyperglycemia-related AGEs including methylglyoxal (MG), free methylglyoxal-derived hydroimidazolone (MG-H1), and protein bound N-(Carboxymethyl)lysine (CML) and N-(Carboxyethyl)lysine (CEL) levels were measured in both SF and plasma samples using liquid chromatography coupled tandem mass spectrometry methodology. The correlation between these AGEs and phosphatidylcholine acyl-alkyl C34:3 (PC ae C34:3) and C36:3 (PC ae C36:3) were examined. Eighty four patients with knee OA, including 46 with DM and 38 without DM, were included in the study. There was no significant difference in plasma levels of MG, MG-H1, CML, and CEL between OA patients with and without DM. However, the levels of MG and MG-H1, but not CML and CEL in SF were significantly higher in OA patients with DM than in those without (all p ≤0.04). This association strengthened after adjustment for age, body mass index (BMI), sex and hexose level (p
- Published
- 2017
19. A classification modeling approach for determining metabolite signatures in osteoarthritis
- Author
-
Rockel, Jason S., primary, Zhang, Weidong, additional, Shestopaloff, Konstantin, additional, Likhodii, Sergei, additional, Sun, Guang, additional, Furey, Andrew, additional, Randell, Edward, additional, Sundararajan, Kala, additional, Gandhi, Rajiv, additional, Zhai, Guangju, additional, and Kapoor, Mohit, additional
- Published
- 2018
- Full Text
- View/download PDF
20. Insectivorous bat reproduction and human cave visitation in Cambodia: A perfect conservation storm?
- Author
-
Lim, Thona, primary, Cappelle, Julien, additional, Hoem, Thavry, additional, and Furey, Neil, additional
- Published
- 2018
- Full Text
- View/download PDF
21. A nonrandomized trial of vitamin D supplementation for Barrett’s esophagus
- Author
-
Cummings, Linda C., primary, Thota, Prashanthi N., additional, Willis, Joseph E., additional, Chen, Yanwen, additional, Cooper, Gregory S., additional, Furey, Nancy, additional, Bednarchik, Beth, additional, Alashkar, Bronia M., additional, Dumot, John, additional, Faulx, Ashley L., additional, Fink, Stephen P., additional, Kresak, Adam M., additional, Abusneineh, Basel, additional, Barnholtz-Sloan, Jill, additional, Leahy, Patrick, additional, Veigl, Martina L., additional, Chak, Amitabh, additional, and Markowitz, Sanford D., additional
- Published
- 2017
- Full Text
- View/download PDF
22. Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes
- Author
-
Zhang, Weidong, primary, Randell, Edward W., additional, Sun, Guang, additional, Likhodii, Sergei, additional, Liu, Ming, additional, Furey, Andrew, additional, and Zhai, Guangju, additional
- Published
- 2017
- Full Text
- View/download PDF
23. Variability in Migration Routes Influences Early Marine Survival of Juvenile Salmon Smolts
- Author
-
David Welch, Scott G. Hinch, Stephen P. Vincent, and Nathan B. Furey
- Subjects
0106 biological sciences ,Georgia ,Oncorhynchus ,Population ,lcsh:Medicine ,010603 evolutionary biology ,01 natural sciences ,Pacific ocean ,Salmon ,Juvenile ,Animals ,Telemetry ,14. Life underwater ,Life history ,education ,lcsh:Science ,education.field_of_study ,Multidisciplinary ,Pacific Ocean ,biology ,010604 marine biology & hydrobiology ,lcsh:R ,biology.organism_classification ,Fishery ,Geography ,Productivity (ecology) ,Oncorhynchus mykiss ,Freshwater fish ,Rainbow trout ,lcsh:Q ,Animal Migration ,Research Article - Abstract
Variability in animal migratory behavior is expected to influence fitness, but few empirical examples demonstrating this relationship exist. The initial marine phase in the migration of juvenile salmon smolts has been identified as a potentially critical life history stage to overall population productivity, yet how fine-scale migration routes may influence survival are unknown. Large-scale acoustic telemetry studies have estimated survival rates of outmigrant Pacific salmon smolts through the Strait of Georgia (SOG) along the British Columbian coastline to the Pacific Ocean, but these data have not been used to identify and characterize fine-scale movements. Data collected on over 850 sockeye salmon (Oncorhynchus nerka) and steelhead (Oncorhynchus mykiss) smolts detected at an array in the Strait of Georgia in 2004–2008 and 2010–2013 were analyzed to characterize migration routes and link movements to subsequent survival at an array 250 km further along the marine migration pathway. Both species exhibited disproportionate use of the most eastern route in the Strait of Georgia (Malaspina Strait). While many smolts moved across the northern Strait of Georgia acoustic array with no indication of long-term milling or large-scale east-to-west movements, large proportions (20–40% of sockeye and 30–50% of steelhead) exhibited a different behavior, apparently moving in a westward or counterclockwise pattern. Variability in migratory behavior for both species was linked to subsequent survival through the Strait of Georgia. Survival for both species was influenced by initial east-to-west location, and sockeye were further influenced by migration timing and duration of time spent near the northern Strait of Georgia array. Westward movements result in a net transport of smolts from Malaspina Strait to the Strait of Georgia, particularly for steelhead. Counterclockwise movements may be due to the currents in this area during the time of outmigration, and the higher proportion of steelhead smolts exhibiting this counterclockwise behavior may reflect a greater exposure to wind-altered currents for the more surface-oriented steelhead. Our results provide an empirical example of how movements can affect migration survival, for which examples remain rare in movement ecology, confirming that variability in movements themselves are an important part of the migratory process.
- Published
- 2015
24. A nonrandomized trial of vitamin D supplementation for Barrett’s esophagus
- Author
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Nancy Furey, Sanford D. Markowitz, John A. Dumot, Patrick Leahy, Ashley L. Faulx, Stephen P. Fink, Jill S. Barnholtz-Sloan, Marty L Veigl, Joseph Willis, Amitabh Chak, Gregory S. Cooper, Prashanthi N. Thota, Adam Kresak, Beth Bednarchik, Basel Abusneineh, Linda C. Cummings, Yanwen Chen, and Bronia M. Alashkar
- Subjects
Male ,Biopsy ,Cancer Treatment ,lcsh:Medicine ,Organic chemistry ,Gene Expression ,Pilot Projects ,Pathology and Laboratory Medicine ,chemistry.chemical_compound ,0302 clinical medicine ,Medicine and Health Sciences ,Vitamin D ,lcsh:Science ,Cholecalciferol ,Multidisciplinary ,Vitamins ,Middle Aged ,Esophageal cancer ,3. Good health ,Physical sciences ,Chemistry ,Nutritional deficiencies ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Hydroxyprostaglandin Dehydrogenases ,Female ,030211 gastroenterology & hepatology ,Research Article ,Vitamin ,Dysplasia ,medicine.medical_specialty ,Surgical and Invasive Medical Procedures ,Chemoprevention ,Gene Expression Regulation, Enzymologic ,vitamin D deficiency ,Barrett Esophagus ,Chemical compounds ,03 medical and health sciences ,Signs and Symptoms ,Diagnostic Medicine ,Internal medicine ,Organic compounds ,Genetics ,medicine ,Vitamin D and neurology ,Humans ,Esophagus ,Aged ,Nutrition ,Vitamin D deficiency ,business.industry ,lcsh:R ,Biology and Life Sciences ,Proton Pump Inhibitors ,Endoscopy ,medicine.disease ,Endocrinology ,chemistry ,Barrett's esophagus ,lcsh:Q ,business - Abstract
Background Vitamin D deficiency may increase esophageal cancer risk. Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH) in other cancers. This nonrandomized interventional study assessed effects of vitamin D supplementation in Barrett’s esophagus (BE). We hypothesized that vitamin D supplementation may have beneficial effects on gene expression including 15-PGDH in BE. Methods BE subjects with low grade or no dysplasia received vitamin D3 (cholecalciferol) 50,000 international units weekly plus a proton pump inhibitor for 12 weeks. Esophageal biopsies from normal plus metaplastic BE epithelium and blood samples were obtained before and after vitamin D supplementation. Serum 25-hydroxyvitamin D was measured to characterize vitamin D status. Esophageal gene expression was assessed using microarrays. Results 18 study subjects were evaluated. The baseline mean serum 25-hydroxyvitamin D level was 27 ng/mL (normal ≥30 ng/mL). After vitamin D supplementation, 25-hydroxyvitamin D levels rose significantly (median increase of 31.6 ng/mL, p
- Published
- 2017
25. Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma
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Hai Yan, Monica Zhang, Gregory E. Crawford, Bum Kyu Lee, Changcun Guo, Terrence S. Furey, Yiping He, Matthew Wortham, Lingyun Song, and Vishwanath R. Iyer
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Chromatin Immunoprecipitation ,lcsh:Medicine ,Biology ,Retinoids ,03 medical and health sciences ,0302 clinical medicine ,Tumor Cells, Cultured ,Genetics ,Cancer Genetics ,Medicine and Health Sciences ,Transcriptional regulation ,Humans ,Blastomas ,Regulatory Elements, Transcriptional ,Cerebellar Neoplasms ,Promoter Regions, Genetic ,lcsh:Science ,Transcription factor ,030304 developmental biology ,Regulation of gene expression ,0303 health sciences ,Otx Transcription Factors ,Multidisciplinary ,General transcription factor ,Chromosome Biology ,lcsh:R ,Biology and Life Sciences ,Cancers and Neoplasms ,Cell Biology ,Oncogenes ,DNA Methylation ,Chromatin ,Cell biology ,Gene Expression Regulation, Neoplastic ,Chromosome Structures ,Oncology ,Regulatory sequence ,030220 oncology & carcinogenesis ,DNA methylation ,Trans-Activators ,lcsh:Q ,Chromatin immunoprecipitation ,Medulloblastoma ,Research Article - Abstract
Despite an emerging understanding of the genetic alterations giving rise to various tumors, the mechanisms whereby most oncogenes are overexpressed remain unclear. Here we have utilized an integrated approach of genomewide regulatory element mapping via DNase-seq followed by conventional reporter assays and transcription factor binding site discovery to characterize the transcriptional regulation of the medulloblastoma oncogene Orthodenticle Homeobox 2 (OTX2). Through these studies we have revealed that OTX2 is differentially regulated in medulloblastoma at the level of chromatin accessibility, which is in part mediated by DNA methylation. In cell lines exhibiting chromatin accessibility of OTX2 regulatory regions, we found that autoregulation maintains OTX2 expression. Comparison of medulloblastoma regulatory elements with those of the developing brain reveals that these tumors engage a developmental regulatory program to drive OTX2 transcription. Finally, we have identified a transcriptional regulatory element mediating retinoid-induced OTX2 repression in these tumors. This work characterizes for the first time the mechanisms of OTX2 overexpression in medulloblastoma. Furthermore, this study establishes proof of principle for applying ENCODE datasets towards the characterization of upstream trans-acting factors mediating expression of individual genes.
- Published
- 2014
26. A Predictive Framework for Integrating Disparate Genomic Data Types Using Sample-Specific Gene Set Enrichment Analysis and Multi-Task Learning
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Brian D. Bennett, Qing Xiong, Sayan Mukherjee, and Terrence S. Furey
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Multidisciplinary ,Science ,lcsh:R ,Correction ,Medicine ,lcsh:Medicine ,lcsh:Q ,lcsh:Science - Published
- 2013
27. Variability in Migration Routes Influences Early Marine Survival of Juvenile Salmon Smolts
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Furey, Nathan B., primary, Vincent, Stephen P., additional, Hinch, Scott G., additional, and Welch, David W., additional
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- 2015
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28. Chromatin Accessibility Mapping Identifies Mediators of Basal Transcription and Retinoid-Induced Repression of OTX2 in Medulloblastoma
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Wortham, Matthew, primary, Guo, Changcun, additional, Zhang, Monica, additional, Song, Lingyun, additional, Lee, Bum-Kyu, additional, Iyer, Vishwanath R., additional, Furey, Terrence S., additional, Crawford, Gregory E., additional, Yan, Hai, additional, and He, Yiping, additional
- Published
- 2014
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29. SMAD3 Is Associated with the Total Burden of Radiographic Osteoarthritis: The Chingford Study
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Aref-Eshghi, Erfan, primary, Zhang, Yuhua, additional, Hart, Deborah, additional, Valdes, Ana M., additional, Furey, Andrew, additional, Martin, Glynn, additional, Sun, Guang, additional, Rahman, Proton, additional, Arden, Nigel, additional, Spector, Tim D., additional, and Zhai, Guangju, additional
- Published
- 2014
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30. Correction: A Predictive Framework for Integrating Disparate Genomic Data Types Using Sample-Specific Gene Set Enrichment Analysis and Multi-Task Learning
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Bennett, Brian D., primary, Xiong, Qing, additional, Mukherjee, Sayan, additional, and Furey, Terrence S., additional
- Published
- 2013
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31. The Extended Functional Neuroanatomy of Emotional Processing Biases for Masked Faces in Major Depressive Disorder
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Victor, Teresa A., primary, Furey, Maura L., additional, Fromm, Stephen J., additional, Bellgowan, Patrick S. F., additional, Öhman, Arne, additional, and Drevets, Wayne C., additional
- Published
- 2012
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32. A Predictive Framework for Integrating Disparate Genomic Data Types Using Sample-Specific Gene Set Enrichment Analysis and Multi-Task Learning
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Bennett, Brian D., primary, Xiong, Qing, additional, Mukherjee, Sayan, additional, and Furey, Terrence S., additional
- Published
- 2012
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33. Distribution and Habitat Associations of Billfish and Swordfish Larvae across Mesoscale Features in the Gulf of Mexico
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Rooker, Jay R., primary, Simms, Jeff R., additional, Wells, R. J. David, additional, Holt, Scott A., additional, Holt, G. Joan, additional, Graves, John E., additional, and Furey, Nathan B., additional
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- 2012
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34. The Extended Functional Neuroanatomy of Emotional Processing Biases for Masked Faces in Major Depressive Disorder
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Wayne C. Drevets, Maura L. Furey, Stephen J. Fromm, Teresa A. Victor, Patrick S.F. Bellgowan, and Arne Öhman
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Neural Networks ,Emotions ,lcsh:Medicine ,Neuroimaging ,Biology ,Emotional processing ,Social and Behavioral Sciences ,behavioral disciplines and activities ,Amygdala ,03 medical and health sciences ,0302 clinical medicine ,mental disorders ,medicine ,Humans ,Psychology ,lcsh:Science ,Psychiatry ,Depressive Disorder, Major ,Behavior ,Facial expression ,Multidisciplinary ,medicine.diagnostic_test ,Mood Disorders ,lcsh:R ,fMRI ,Brain ,Response bias ,medicine.disease ,Magnetic Resonance Imaging ,030227 psychiatry ,Facial Expression ,Mental Health ,medicine.anatomical_structure ,Case-Control Studies ,Functional neuroanatomy ,Medicine ,Major depressive disorder ,lcsh:Q ,Functional magnetic resonance imaging ,030217 neurology & neurosurgery ,Research Article ,Neuroscience ,Cognitive psychology - Abstract
Background Major depressive disorder (MDD) is associated with a mood-congruent processing bias in the amygdala toward face stimuli portraying sad expressions that is evident even when such stimuli are presented below the level of conscious awareness. The extended functional anatomical network that maintains this response bias has not been established, however. Aims To identify neural network differences in the hemodynamic response to implicitly presented facial expressions between depressed and healthy control participants. Method Unmedicated-depressed participants with MDD (n = 22) and healthy controls (HC; n = 25) underwent functional MRI as they viewed face stimuli showing sad, happy or neutral face expressions, presented using a backward masking design. The blood-oxygen-level dependent (BOLD) signal was measured to identify regions where the hemodynamic response to the emotionally valenced stimuli differed between groups. Results The MDD subjects showed greater BOLD responses than the controls to masked-sad versus masked-happy faces in the hippocampus, amygdala and anterior inferotemporal cortex. While viewing both masked-sad and masked-happy faces relative to masked-neutral faces, the depressed subjects showed greater hemodynamic responses than the controls in a network that included the medial and orbital prefrontal cortices and anterior temporal cortex. Conclusions Depressed and healthy participants showed distinct hemodynamic responses to masked-sad and masked-happy faces in neural circuits known to support the processing of emotionally valenced stimuli and to integrate the sensory and visceromotor aspects of emotional behavior. Altered function within these networks in MDD may establish and maintain illness-associated differences in the salience of sensory/social stimuli, such that attention is biased toward negative and away from positive stimuli.
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- 2012
35. Distribution and Habitat Associations of Billfish and Swordfish Larvae across Mesoscale Features in the Gulf of Mexico
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Nathan B. Furey, John E. Graves, Jeff R. Simms, Jay R. Rooker, R. J. David Wells, G. Joan Holt, and Scott A. Holt
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Time Factors ,lcsh:Medicine ,Marine Biology ,Ecosystems ,Perciformes ,Marine Conservation ,Marine Monitoring ,Oceans ,Animals ,Seawater ,cvg ,lcsh:Science ,Biology ,Ecosystem ,Gulf of Mexico ,Billfish ,Multidisciplinary ,Ecology ,biology ,Blue marlin ,Swordfish ,cvg.computer_videogame ,lcsh:R ,Marine Ecology ,White marlin ,Fisheries Science ,Models, Theoretical ,Ichthyoplankton ,Sailfish ,biology.organism_classification ,Marine Environments ,Marine and aquatic sciences ,Fishery ,Earth sciences ,Larva ,lcsh:Q ,Zoology ,Mahi-mahi ,Coastal Ecology ,Ichthyology ,Research Article ,Ecological Environments - Abstract
Ichthyoplankton surveys were conducted in surface waters of the northern Gulf of Mexico (NGoM) over a three-year period (2006-2008) to determine the relative value of this region as early life habitat of sailfish (Istiophorus platypterus), blue marlin (Makaira nigricans), white marlin (Kajikia albida), and swordfish (Xiphias gladius). Sailfish were the dominant billfish collected in summer surveys, and larvae were present at 37.5% of the stations sampled. Blue marlin and white marlin larvae were present at 25.0% and 4.6% of the stations sampled, respectively, while swordfish occurred at 17.2% of the stations. Areas of peak production were detected and maximum density estimates for sailfish (22.09 larvae 1000 m(-2)) were significantly higher than the three other species: blue marlin (9.62 larvae 1000 m(-2)), white marlin (5.44 larvae 1000 m(-2)), and swordfish (4.67 larvae 1000 m(-2)). The distribution and abundance of billfish and swordfish larvae varied spatially and temporally, and several environmental variables (sea surface temperature, salinity, sea surface height, distance to the Loop Current, current velocity, water depth, and Sargassum biomass) were deemed to be influential variables in generalized additive models (GAMs). Mesoscale features in the NGoM affected the distribution and abundance of billfish and swordfish larvae, with densities typically higher in frontal zones or areas proximal to the Loop Current. Habitat suitability of all four species was strongly linked to physicochemical attributes of the water masses they inhabited, and observed abundance was higher in slope waters with lower sea surface temperature and higher salinity. Our results highlight the value of the NGoM as early life habitat of billfishes and swordfish, and represent valuable baseline data for evaluating anthropogenic effects (i.e., Deepwater Horizon oil spill) on the Atlantic billfish and swordfish populations.
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- 2012
36. SMAD3 Is Associated with the Total Burden of Radiographic Osteoarthritis: The Chingford Study.
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Aref-Eshghi, Erfan, Zhang, Yuhua, Hart, Deborah, Valdes, Ana M., Furey, Andrew, Martin, Glynn, Sun, Guang, Rahman, Proton, Arden, Nigel, Spector, Tim D., and Zhai, Guangju
- Subjects
SMAD proteins ,OSTEOARTHRITIS diagnosis ,ANEURYSMS ,MEDICAL radiography ,GENETIC mutation ,BONE spurs ,SINGLE nucleotide polymorphisms - Abstract
Background: A newly-described syndrome called Aneurysm-Osteoarthritis Syndrome (AOS) was recently reported. AOS presents with early onset osteoarthritis (OA) in multiple joints, together with aneurysms in major arteries, and is caused by rare mutations in SMAD3. Because of the similarity of AOS to idiopathic generalized OA (GOA), we hypothesized that SMAD3 is also associated with GOA and tested the hypothesis in a population-based cohort. Methods: Study participants were derived from the Chingford study. Kellgren-Lawrence (KL) grades and the individual features of osteophytes and joint space narrowing (JSN) were scored from radiographs of hands, knees, hips, and lumbar spines. The total KL score, osteophyte score, and JSN score were calculated and used as indicators of the total burden of radiographic OA. Forty-one common SNPs within SMAD3 were genotyped using the Illumina HumanHap610Q array. Linear regression modelling was used to test the association between the total KL score, osteophyte score, and JSN score and each of the 41 SNPs, with adjustment for patient age and BMI. Permutation testing was used to control the false positive rate. Results: A total of 609 individuals were included in the analysis. All were Caucasian females with a mean age of 60.9±5.8. We found that rs3825977, with a minor allele (T) frequency of 20%, in the last intron of SMAD3, was significantly associated with total KL score (β = 0.14, P
permutation = 0.002). This association was stronger for the total JSN score (β = 0.19, Ppermutation = 0.002) than for total osteophyte score (β = 0.11, Ppermutation = 0.02). The T allele is associated with a 1.47-fold increased odds for people with 5 or more joints to be affected by radiographic OA (Ppermutation = 0.046). Conclusion: We found that SMAD3 is significantly associated with the total burden of radiographic OA. Further studies are required to reveal the mechanism of the association. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
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