1. The effect of HIV infection and HCV viremia on inflammatory mediators and hepatic injury—The Women’s Interagency HIV Study
- Author
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Keating, Sheila M, Dodge, Jennifer L, Norris, Philip J, Heitman, John, Gange, Stephen J, French, Audrey L, Glesby, Marshall J, Edlin, Brian R, Latham, Patricia S, Villacres, Maria C, Greenblatt, Ruth M, and Peters, Marion G
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Liver Disease ,Hepatitis - C ,Hepatitis ,Sexually Transmitted Infections ,Emerging Infectious Diseases ,HIV/AIDS ,Digestive Diseases ,Chronic Liver Disease and Cirrhosis ,Clinical Research ,Infectious Diseases ,6.1 Pharmaceuticals ,Aetiology ,Evaluation of treatments and therapeutic interventions ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Infection ,Good Health and Well Being ,AIDS-Related Opportunistic Infections ,Adult ,Case-Control Studies ,Coinfection ,Female ,HIV Infections ,HIV-1 ,Hepacivirus ,Hepatitis C ,Humans ,Inflammation Mediators ,Liver Cirrhosis ,Middle Aged ,Viremia ,Women’s Interagency HIV Study ,General Science & Technology - Abstract
Hepatitis C virus infection induces inflammation and while it is believed that HIV co-infection enhances this response, HIV control may reduce inflammation and liver fibrosis in resolved or viremic HCV infection. Measurement of systemic biomarkers in co-infection could help define the mechanism of inflammation on fibrosis and determine if HIV control reduces liver pathology. A nested case-control study was performed to explore the relationship of systemic biomarkers of inflammation with liver fibrosis in HCV viremic and/or seropositive women with and without HIV infection. Serum cytokines, chemokines, growth factors and cell adhesion molecules were measured in HIV uninfected (HIV-, n = 18), ART-treated HIV-controlled (ARTc, n = 20), uncontrolled on anti-retroviral therapy (ARTuc, n = 21) and elite HIV controllers (Elite, n = 20). All were HCV seroreactive and had either resolved (HCV RNA-;
- Published
- 2017