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Your search keyword '"Graham, Mark"' showing total 14 results
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14 results on '"Graham, Mark"'

2. The mental health burden of racial and ethnic minorities during the COVID-19 pandemic

Author

Nguyen, Long H., primary, Anyane-Yeboa, Adjoa, additional, Klaser, Kerstin, additional, Merino, Jordi, additional, Drew, David A., additional, Ma, Wenjie, additional, Mehta, Raaj S., additional, Kim, Daniel Y., additional, Warner, Erica T., additional, Joshi, Amit D., additional, Graham, Mark S., additional, Sudre, Carole H., additional, Thompson, Ellen J., additional, May, Anna, additional, Hu, Christina, additional, Jørgensen, Solveig, additional, Selvachandran, Somesh, additional, Berry, Sarah E., additional, David, Sean P., additional, Martinez, Maria Elena, additional, Figueiredo, Jane C., additional, Murray, Anne M., additional, Sanders, Alan R., additional, Koenen, Karestan C., additional, Wolf, Jonathan, additional, Ourselin, Sebastien, additional, Spector, Tim D., additional, Steves, Claire J., additional, and Chan, Andrew T., additional

Published
2022
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5. Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development

Author

Kim, Seonwook, primary, Yang, Lihua, additional, Kim, Seongu, additional, Lee, Richard G., additional, Graham, Mark J., additional, Berliner, Judith A., additional, Lusis, Aldons J., additional, Cai, Lei, additional, Temel, Ryan E., additional, Rateri, Debra L., additional, and Lee, Sangderk, additional

Published
2017
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7. Quantitative assessment of the susceptibility artefact and its interaction with motion in diffusion MRI.

Author

Drobnjak, Ivana, Zhang, Hui, Jenkinson, Mark, and Graham, Mark S.

Subjects
DISEASE susceptibility, MAGNETIC resonance imaging, RADIATIVE corrections, IRREGULARITIES of distribution (Number theory), SIMULATION methods & models
Abstract

In this paper we evaluate the three main methods for correcting the susceptibility-induced artefact in diffusion-weighted magnetic-resonance (DW-MR) data, and assess how correction is affected by the susceptibility field’s interaction with motion. The susceptibility artefact adversely impacts analysis performed on the data and is typically corrected in post-processing. Correction strategies involve either registration to a structural image, the application of an acquired field-map or the use of additional images acquired with different phase-encoding. Unfortunately, the choice of which method to use is made difficult by the absence of any systematic comparisons of them. In this work we quantitatively evaluate these methods, by extending and employing a recently proposed framework that allows for the simulation of realistic DW-MR datasets with artefacts. Our analysis separately evaluates the ability for methods to correct for geometric distortions and to recover lost information in regions of signal compression. In terms of geometric distortions, we find that registration-based methods offer the poorest correction. Field-mapping techniques are better, but are influenced by noise and partial volume effects, whilst multiple phase-encode methods performed best. We use our simulations to validate a popular surrogate metric of correction quality, the comparison of corrected data acquired with AP and LR phase-encoding, and apply this surrogate to real datasets. Furthermore, we demonstrate that failing to account for the interaction of the susceptibility field with head movement leads to increased errors when analysing DW-MR data. None of the commonly used post-processing methods account for this interaction, and we suggest this may be a valuable area for future methods development. [ABSTRACT FROM AUTHOR]

Published
2017
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9. Acute Sterol O-Acyltransferase 2 (SOAT2) Knockdown Rapidly Mobilizes Hepatic Cholesterol for Fecal Excretion

Author

Marshall, Stephanie M., primary, Gromovsky, Anthony D., additional, Kelley, Kathryn L., additional, Davis, Matthew A., additional, Wilson, Martha D., additional, Lee, Richard G., additional, Crooke, Rosanne M., additional, Graham, Mark J., additional, Rudel, Lawrence L., additional, Brown, J. Mark, additional, and Temel, Ryan E., additional

Published
2014
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10. Hepatic ACAT2 Knock Down Increases ABCA1 and Modifies HDL Metabolism in Mice

Author

Pedrelli, Matteo, primary, Davoodpour, Padideh, additional, Degirolamo, Chiara, additional, Gomaraschi, Monica, additional, Graham, Mark, additional, Ossoli, Alice, additional, Larsson, Lilian, additional, Calabresi, Laura, additional, Gustafsson, Jan-Åke, additional, Steffensen, Knut R., additional, Eriksson, Mats, additional, and Parini, Paolo, additional

Published
2014
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11. Reduction of VLDL Secretion Decreases Cholesterol Excretion in Niemann-Pick C1-Like 1 Hepatic Transgenic Mice

Author

Marshall, Stephanie M., primary, Kelley, Kathryn L., additional, Davis, Matthew A., additional, Wilson, Martha D., additional, McDaniel, Allison L., additional, Lee, Richard G., additional, Crooke, Rosanne M., additional, Graham, Mark J., additional, Rudel, Lawrence L., additional, Brown, J. Mark, additional, and Temel, Ryan E., additional

Published
2014
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14. The ∼ 16 kDa C-terminal sequence of clathrin assembly protein AP180 is essential for efficient clathrin binding.

Author

Chan LS, Moshkanbaryans L, Xue J, and Graham ME

Subjects
Amino Acid Motifs, Amino Acid Sequence, Animals, COS Cells, Chlorocebus aethiops, Clathrin genetics, Clathrin metabolism, Mice, Monomeric Clathrin Assembly Proteins genetics, Monomeric Clathrin Assembly Proteins metabolism, Protein Binding, Protein Structure, Tertiary, Clathrin chemistry, Monomeric Clathrin Assembly Proteins chemistry
Abstract

Brain-specific AP180 is present in clathrin coats at equal concentration to the adapter complex, AP2, and assembles clathrin faster than any other protein in vitro. Both AP180 and its ubiquitously expressed homolog clathrin assembly lymphoid myeloid leukemia protein (CALM) control vesicle size and shape in clathrin mediated endocytosis. The clathrin assembly role of AP180 is mediated by a long disordered C-terminal assembly domain. Within this assembly domain, a central acidic clathrin and adapter binding (CLAP) sub-domain contains all of the known short binding motifs for clathrin and AP2. The role of the remaining ∼ 16 kDa C-terminal sequence has not been clear. We show that this sequence has a separate function in ensuring efficient binding of clathrin, based on in vitro binding and ex vivo transferrin uptake assays. Sequence alignment suggests the C-terminal sub-domain is conserved in CALM.

Published
2014
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