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Your search keyword '"Gupta, Rakesh"' showing total 16 results
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16 results on '"Gupta, Rakesh"'

3. Lessons from implementation research on community management of Possible Serious Bacterial Infection (PSBI) in young infants (0-59 days), when the referral is not feasible in Palwal district of Haryana, India

Author

Mukhopadhyay, Rupak, primary, Arora, Narendra Kumar, additional, Sharma, Pradeep Kumar, additional, Dalpath, Suresh, additional, Limbu, Priya, additional, Kataria, Geetanjali, additional, Singh, Rakesh Kumar, additional, Poluru, Ramesh, additional, Malik, Yogesh, additional, Khera, Ajay, additional, Prabhakar, P. K., additional, Kumar, Saket, additional, Gupta, Rakesh, additional, Chellani, Harish, additional, Aggarwal, Kailash Chander, additional, Gupta, Ratan, additional, Arya, Sugandha, additional, Aboubaker, Samira, additional, Bahl, Rajiv, additional, Nisar, Yasir Bin, additional, and Qazi, Shamim Ahmad, additional

Published
2021
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4. High throughput detection and genetic epidemiology of SARS-CoV-2 using COVIDSeq next-generation sequencing

Author

Bhoyar, Rahul C., primary, Jain, Abhinav, additional, Sehgal, Paras, additional, Divakar, Mohit Kumar, additional, Sharma, Disha, additional, Imran, Mohamed, additional, Jolly, Bani, additional, Ranjan, Gyan, additional, Rophina, Mercy, additional, Sharma, Sumit, additional, Siwach, Sanjay, additional, Pandhare, Kavita, additional, Sahoo, Swayamprabha, additional, Sahoo, Maheswata, additional, Nayak, Ananya, additional, Mohanty, Jatindra Nath, additional, Das, Jayashankar, additional, Bhandari, Sudhir, additional, Mathur, Sandeep K., additional, Kumar, Anshul, additional, Sahlot, Rahul, additional, Rojarani, Pallavali, additional, Lakshmi, Juturu Vijaya, additional, Surekha, Avileli, additional, Sekhar, Pulala Chandra, additional, Mahajan, Shelly, additional, Masih, Shet, additional, Singh, Pawan, additional, Kumar, Vipin, additional, Jose, Blessy, additional, Mahajan, Vidur, additional, Gupta, Vivek, additional, Gupta, Rakesh, additional, Arumugam, Prabhakar, additional, Singh, Anjali, additional, Nandy, Ananya, additional, P. V., Ragavendran, additional, Jha, Rakesh Mohan, additional, Kumari, Anupama, additional, Gandotra, Sheetal, additional, Rao, Vivek, additional, Faruq, Mohammed, additional, Kumar, Sanjeev, additional, Reshma G., Betsy, additional, Varma G., Narendra, additional, Roy, Shuvra Shekhar, additional, Sengupta, Antara, additional, Chattopadhyay, Sabyasachi, additional, Singhal, Khushboo, additional, Pradhan, Shalini, additional, Jha, Diksha, additional, Naushin, Salwa, additional, Wadhwa, Saruchi, additional, Tyagi, Nishu, additional, Poojary, Mukta, additional, Scaria, Vinod, additional, and Sivasubbu, Sridhar, additional

Published
2021
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5. Utility of circulating cell-free Mycobacterium tuberculosis DNA for the improved diagnosis of abdominal tuberculosis

Author

Sharma, Pratibha, primary, Anthwal, Divya, additional, Kumari, Pooja, additional, Gupta, Rakesh Kumar, additional, Lavania, Surabhi, additional, Sharma, Neera, additional, Sharma, Lokesh Kumar, additional, Rath, Deepak, additional, Soraganvi, Pavan Kumar, additional, Sharma, Ashish, additional, Gadpayle, A. K., additional, Taneja, R. S., additional, Tyagi, Jaya Sivaswami, additional, and Haldar, Sagarika, additional

Published
2020
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6. Development and evaluation of novel bio-safe filter paper-based kits for sputum microscopy and transport to directly detect Mycobacterium tuberculosis and associated drug resistance

Author

Anthwal, Divya, primary, Lavania, Surabhi, additional, Gupta, Rakesh Kumar, additional, Verma, Ajoy, additional, Myneedu, Vithal Prasad, additional, Sharma, Prem Prakash, additional, Verma, Hitesh, additional, Malhotra, Viveksheel, additional, Gupta, Ashawant, additional, Gupta, Nalini Kant, additional, Sarin, Rohit, additional, Haldar, Sagarika, additional, and Tyagi, Jaya Sivaswami, additional

Published
2019
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15. Endonuclease IV Is the Major Apurinic/Apyrimidinic Endonuclease in Mycobacterium tuberculosis and Is Important for Protection against Oxidative Damage.

Author

Puri, Rupangi Verma, Singh, Nisha, Gupta, Rakesh K., and Tyagi, Anil K.

Subjects
ENDONUCLEASES, MYCOBACTERIUM tuberculosis, OXIDATIVE stress, BACTERIAL diseases, DNA damage, BACTERIAL enzymes, ENZYME kinetics
Abstract

During the establishment of an infection, bacterial pathogens encounter oxidative stress resulting in the production of DNA lesions. Majority of these lesions are repaired by base excision repair (BER) pathway. Amongst these, abasic sites are the most frequent lesions in DNA. Class II apurinic/apyrimidinic (AP) endonucleases play a major role in BER of damaged DNA comprising of abasic sites. Mycobacterium tuberculosis, a deadly pathogen, resides in the human macrophages and is continually subjected to oxidative assaults. We have characterized for the first time two AP endonucleases namely Endonuclease IV (End) and Exonuclease III (XthA) that perform distinct functions in M.tuberculosis. We demonstrate that M.tuberculosis End is a typical AP endonuclease while XthA is predominantly a 3′→5′ exonuclease. The AP endonuclease activity of End and XthA was stimulated by Mg2+ and Ca2+ and displayed a preferential recognition for abasic site paired opposite to a cytosine residue in DNA. Moreover, End exhibited metal ion independent 3′→5′ exonuclease activity while in the case of XthA this activity was metal ion dependent. We demonstrate that End is not only a more efficient AP endonuclease than XthA but it also represents the major AP endonuclease activity in M.tuberculosis and plays a crucial role in defense against oxidative stress. [ABSTRACT FROM AUTHOR]

Published
2013
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16. SCOPE: Surveillance of COVID-19 in pregnancy- results of a multicentric ambispective case-control study on clinical presentation and maternal outcomes in India between April to November 2020.

Author

Kumar S, Bhatla N, Sharma KA, Agarwal R, Verma A, Perumal V, Shiv Kumar P, Garg BS, Goudar SS, Pujar YV, Kavi A, Suri V, Joshi B, Rathore A, Gupta MM, Kumar A, Puri M, Meena D, Nangia S, Arora R, Bachani S, Anand P, Seth S, Gupta R, Sehgal R, Rana A, Kumari A, P S, Donimath K, Gowder G, Kedar L, Kar T, Mishra S, Joshi C, Kabade Y, Kamatar S, Nanda S, Mohapatra V, Vellanki J, Agarwal S, Borkar AW, Kumar A, Sultan S, Gangane N, Chaudhary P, Jayathilaka A, Raina N, and Karna P

Subjects
Pregnancy, Humans, Female, Case-Control Studies, India epidemiology, Mothers, COVID-19 epidemiology, Abruptio Placentae
Abstract

Objective: To determine the clinical manifestations, risk factors, treatment modalities and maternal outcomes in pregnant women with lab-confirmed COVID-19 and compare it with COVID-19 negative pregnant women in same age group., Design: Multicentric case-control study., Data Sources: Ambispective primary data collection through paper-based forms from 20 tertiary care centres across India between April and November 2020., Study Population: All pregnant women reporting to the centres with a lab-confirmed COVID-19 positive result matched with controls., Data Quality: Dedicated research officers extracted hospital records, using modified WHO Case Record Forms (CRF) and verified for completeness and accuracy., Statistical Analysis: Data converted to excel files and statistical analyses done using STATA 16 (StataCorp, TX, USA). Odds ratios (ORs) with 95% confidence intervals (CI) estimated using unconditional logistic regression., Results: A total of 76,264 women delivered across 20 centres during the study period. Data of 3723 COVID positive pregnant women and 3744 age-matched controls was analyzed. Of the positive cases 56·9% were asymptomatic. Antenatal complications like preeclampsia and abruptio placentae were seen more among the cases. Induction and caesarean delivery rates were also higher among Covid positive women. Pre-existing maternal co-morbidities increased need for supportive care. There were 34 maternal deaths out of the 3723(0.9%) positive mothers, while covid negative deaths reported from all the centres were 449 of 72,541 (0·6%)., Conclusion: Covid-19 infection predisposed to adverse maternal outcomes in a large cohort of Covid positive pregnant women as compared to the negative controls., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Kumar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Published
2023
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