Search

Your search keyword '"Hachimura, Satoshi"' showing total 6 results
Start Over Author "Hachimura, Satoshi" Journal plos one
6 results on '"Hachimura, Satoshi"'

2. Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy

Author

Nakajima-Adachi, Haruyo, primary, Shibahara, Kyoko, additional, Fujimura, Yoko, additional, Takeyama, Jun, additional, Hiraide, Erika, additional, Kikuchi, Akira, additional, Murakami, Hitoshi, additional, Hosono, Akira, additional, Nochi, Tomonori, additional, Wakatsuki, Yoshio, additional, Shimojo, Naoki, additional, Kaminogawa, Shuichi, additional, Sato, Ryuichiro, additional, Kiyono, Hiroshi, additional, and Hachimura, Satoshi, additional

Published
2017
Full Text
View/download PDF

4. Peyer’s Patches and Mesenteric Lymph Nodes Cooperatively Promote Enteropathy in a Mouse Model of Food Allergy

Author

Nakajima-Adachi, Haruyo, primary, Kikuchi, Akira, additional, Fujimura, Yoko, additional, Shibahara, Kyoko, additional, Makino, Tsuyoshi, additional, Goseki-Sone, Masae, additional, Kihara-Fujioka, Miran, additional, Nochi, Tomonori, additional, Kurashima, Yosuke, additional, Igarashi, Osamu, additional, Yamamoto, Masafumi, additional, Kunisawa, Jun, additional, Toda, Masako, additional, Kaminogawa, Shuichi, additional, Sato, Ryuichiro, additional, Kiyono, Hiroshi, additional, and Hachimura, Satoshi, additional

Published
2014
Full Text
View/download PDF

5. Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice

Author

Kikuchi, Yosuke, primary, Kunitoh-Asari, Ayami, additional, Hayakawa, Katsuyuki, additional, Imai, Shinjiro, additional, Kasuya, Kenji, additional, Abe, Kimio, additional, Adachi, Yu, additional, Fukudome, Shin-ichi, additional, Takahashi, Yoshimasa, additional, and Hachimura, Satoshi, additional

Published
2014
Full Text
View/download PDF

6. Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice.

Author

Kikuchi, Yosuke, Kunitoh-Asari, Ayami, Hayakawa, Katsuyuki, Imai, Shinjiro, Kasuya, Kenji, Abe, Kimio, Adachi, Yu, Fukudome, Shin-ichi, Takahashi, Yoshimasa, and Hachimura, Satoshi

Subjects
LACTOBACILLUS plantarum, IMMUNOGLOBULIN A, SECRETION, INFLUENZA prevention, IMMUNE system, ORAL drug administration, PATHOGENIC microorganisms, LABORATORY mice
Abstract

The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA production by murine Peyer’s patch cells. We selected one strain and named it Lactobacillus plantarum AYA. We found that L. plantarum AYA-induced production of IL-6 in Peyer’s patch dendritic cells, with this production promoting IgA+ B cells to differentiate into IgA-secreting plasma cells. We also observed that oral administration of L. plantarum AYA in mice caused an increase in IgA production in the small intestine and lung. This production of IgA correlated strongly with protective ability, with the treated mice surviving longer than the control mice after lethal influenza virus infection. Our data therefore reveals a novel immunoregulatory role of the L. plantarum AYA strain which enhances mucosal IgA production and provides protection against respiratory influenza virus infection. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results