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6. A Pivotal Role of Vitamin B9 in the Maintenance of Regulatory T Cells In Vitro and In Vivo.

Author

Jun Kunisawa, Hashimoto, Eri, Ishikawa, Izumi, and Kiyono, Hiroshi

Subjects
*VITAMIN B complex, *T cells, *IMMUNE system, *SMALL intestine, *HOMEOSTASIS
Abstract

Dietary factors regulate immunological function, but the underlying mechanisms remain elusive. Here we show that vitamin B9 is a survival factor for regulatory T (Treg) cells expressing high levels of vitamin B9 receptor (folate receptor 4). In vitamin B9- reduced condition in vitro, Treg cells could be differentiated fromnaïve T cells but failed to survive. The impaired survival of Treg cells was associated with decreased expression of anti-apoptotic Bcl2 and independent of IL-2. In vivo depletion of dietary vitamin B9 resulted in the reduction of Treg cells in the small intestine, a site for the absorption of dietary vitamin B9. These findings provide a new link between diet and the immune system, which could maintain the immunological homeostasis in the intestine. [ABSTRACT FROM AUTHOR]

Published
2012
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