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2. Discriminating hepatocellular carcinoma in rats using a high-Tc SQUID detected nuclear resonance spectrometer in a magnetic shielding box.

Author

Kai-Wen Huang, Hsin-Hsien Chen, Hong-Chang Yang, Herng-Er Horng, Shu-Hsien Liao, Shieh Yueh Yang, Jen-Jie Chieh, and Li-Ming Wang

Subjects
Medicine, Science
Abstract

In this study, we report the spin-lattice relaxation rate of hepatocellular carcinoma (HCC) and normal liver tissue in rats using a high-T(c) superconducting quantum interference device (SQUID) based nuclear magnetic resonance (NMR) spectrometer. The resonance spectrometer used for discriminating liver tumors in rats via the difference in longitudinal relaxation time in low magnetic fields was set up in a compact and portable magnetic shielding box. The frequency-domain NMR signals of HCC tissues and normal liver tissues were analyzed to study their respective longitudinal relaxation rate T(1) (-1). The T(1) (-1) of liver tissues for ten normal rats and ten cancerous rats were investigated respectively. The averaged T(1) (-1) value of normal liver tissue was (6.41±0.66) s(-1), and the averaged T(1) (-1) value of cancerous tissue was (3.38±0.15) s(-1). The ratio of T(1) (-1) for normal liver tissues and cancerous liver tissues of the rats investigated is estimated to be 1.9. Since this significant statistical difference, the T(1) (-1) value can be used to distinguish the HCC tissues from normal liver tissues. This method of examining liver and tumor tissues has the advantages of being convenient, easy to operate, and stable.

Published
2012
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4. Discriminating hepatocellular carcinoma in rats using a high-Tc SQUID detected nuclear resonance spectrometer in a magnetic shielding box

Author

Li Ming Wang, Hong-Chang Yang, Shieh Yueh Yang, Jen Jie Chieh, Herng-Er Horng, Hsin Hsien Chen, Shu Hsien Liao, and Kai-Wen Huang

Subjects
Male, Pathology, Medical Physics, Magnetic Resonance Spectroscopy, Magnetic Properties, Systems Engineering, lcsh:Medicine, law.invention, Engineering, law, Materials Physics, Reference Values, Biological Systems Engineering, lcsh:Science, Multidisciplinary, medicine.diagnostic_test, Chemistry, Liver Diseases, Physics, Liver Neoplasms, Nuclear magnetic resonance spectroscopy, Equipment Design, Clinical Laboratory Sciences, SQUID, Hepatocellular carcinoma, Electromagnetic shielding, Interdisciplinary Physics, Medicine, Materials Characterization, Research Article, Biotechnology, medicine.medical_specialty, Histology, Carcinoma, Hepatocellular, Clinical Research Design, Radiation Biophysics, Materials Science, Material Properties, Biophysics, Biomedical Engineering, Bioengineering, Gastroenterology and Hepatology, Medical Devices, Natural Materials, Diagnostic Medicine, medicine, Carcinoma, Animals, Rats, Wistar, Radiometry, Biology, Nuclear Physics, Spectrometer, lcsh:R, Resonance, Radiobiology, Magnetic resonance imaging, medicine.disease, Rats, lcsh:Q
Abstract

In this study, we report the spin-lattice relaxation rate of hepatocellular carcinoma (HCC) and normal liver tissue in rats using a high-T(c) superconducting quantum interference device (SQUID) based nuclear magnetic resonance (NMR) spectrometer. The resonance spectrometer used for discriminating liver tumors in rats via the difference in longitudinal relaxation time in low magnetic fields was set up in a compact and portable magnetic shielding box. The frequency-domain NMR signals of HCC tissues and normal liver tissues were analyzed to study their respective longitudinal relaxation rate T(1) (-1). The T(1) (-1) of liver tissues for ten normal rats and ten cancerous rats were investigated respectively. The averaged T(1) (-1) value of normal liver tissue was (6.41±0.66) s(-1), and the averaged T(1) (-1) value of cancerous tissue was (3.38±0.15) s(-1). The ratio of T(1) (-1) for normal liver tissues and cancerous liver tissues of the rats investigated is estimated to be 1.9. Since this significant statistical difference, the T(1) (-1) value can be used to distinguish the HCC tissues from normal liver tissues. This method of examining liver and tumor tissues has the advantages of being convenient, easy to operate, and stable.

Published
2012

5. Discriminating Hepatocellular Carcinoma in Rats Using a High-Tc SQUID Detected Nuclear Resonance Spectrometer in a Magnetic Shielding Box.

Author

Kai-Wen Huang, Hsin-Hsien Chen, Hong-Chang Yang, Herng-Er Horng, Shu-Hsien Liao, Shieh Yueh Yang, Jen-Jie Chieh, and Li-Ming Wang

Subjects
LIVER cancer, SPIN-lattice relaxation, SUPERCONDUCTING quantum interference devices, SPECTROMETERS, LIVER tumors, RATS
Abstract

In this study, we report the spin-lattice relaxation rate of hepatocellular carcinoma (HCC) and normal liver tissue in rats using a high-Tc superconducting quantum interference device (SQUID) based nuclear magnetic resonance (NMR) spectrometer. The resonance spectrometer used for discriminating liver tumors in rats via the difference in longitudinal relaxation time in low magnetic fields was set up in a compact and portable magnetic shielding box. The frequency-domain NMR signals of HCC tissues and normal liver tissues were analyzed to study their respective longitudinal relaxation rate T1-1. The T1-1 of liver tissues for ten normal rats and ten cancerous rats were investigated respectively. The averaged T1 value of normal liver tissue was (6.41±0.66) s-1, and the averaged T1-1 value of cancerous tissue was (3.38±0.15) s-1. The ratio of T1-1 for normal liver tissues and cancerous liver tissues of the rats investigated is estimated to be 1.9. Since this significant statistical difference, the T1-1 value can be used to distinguish the HCC tissues from normal liver tissues. This method of examining liver and tumor tissues has the advantages of being convenient, easy to operate, and stable. [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
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