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31 results on '"Hummel, Thomas"'

1. Hot topic: Mapping of the human intranasal mucosal thermal sensitivity: A clinical study on thermal threshold and trigeminal receptors.

Author

Weise, Susanne, Hanslik, Pauline, Mignot, Coralie, Glushkov, Evgenii, Bertsch, Arnaud, Dubreuil, Romain, Bensafi, Moustafa, Fuessel, Susanne, and Hummel, Thomas

Subjects
TRP channels, GENE expression, TRPV cation channels
Abstract

Introduction: The olfactory and trigeminal system are closely interlinked. Existing literature has primarily focused on characterizing trigeminal stimulation through mechanical and chemical stimulation, neglecting thermal stimulation thus far. The present study aimed to characterize the intranasal sensitivity to heat and the expression of trigeminal receptors (transient receptor potential channels, TRP). Methods: A total of 20 healthy participants (aged 21–27 years, 11 women) were screened for olfactory function and trigeminal sensitivity using several tests. Under endoscopic control, a thermal stimulator was placed in 7 intranasal locations: anterior septum, lateral vestibulum, interior nose tip, lower turbinate, middle septum, middle turbinate, and olfactory cleft to determine the thermal threshold. Nasal swabs were obtained in 3 different locations (anterior septum, middle turbinate, olfactory cleft) to analyze the expression of trigeminal receptors TRP: TRPV1, TRPV3, TRPA1, TRPM8. Results: The thermal threshold differed between locations (p = 0.018), with a trend for a higher threshold at the anterior septum (p = 0.092). There were no differences in quantitative receptor expression (p = 0.46) at the different sites. The highest overall receptor RNA expression was detected for TRPV1 over all sites (p<0.001). The expression of TRPV3 was highest at the anterior septum compared to the middle turbinate or the olfactory cleft. The thermal sensitivity correlated with olfactory sensitivity and results from tests were related to trigeminal function like intensity ratings of ammonium, a questionnaire regarding trigeminal function, nasal patency, and CO2 thresholds. However, no correlation was found between receptor expression and psychophysical measures of trigeminal function. Discussion: This study provided the first insights about intranasal thermal sensitivity and suggested the presence of topographical differences in thermal thresholds. There was no correlation between thermal sensitivity and trigeminal mRNA receptor expression. However, thermal sensitivity was found to be associated with psychophysical measures of trigeminal and olfactory function. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Time frequency analysis of olfactory induced EEG-power change

Author

Schriever, Valentin Alexander, Han, Pengfei, Weise, Stefanie, Hösel, Franziska, Pellegrino, Robert, and Hummel, Thomas

Subjects
Male, Research Validity, Physiology, lcsh:Medicine, Event-Related Potentials, Social Sciences, Electrode Recording, Olfaction Disorders, Medicine and Health Sciences, Psychology, olfaction, physiological evaluations, menthol lateralization test, olfactory stimulus delivery devices, Technische Universität Dresden, Publishing Fund, lcsh:Science, Membrane Electrophysiology, Clinical Neurophysiology, Brain Mapping, Eukaryota, Electroencephalography, Plants, Research Assessment, Middle Aged, Phenylethyl Alcohol, Legumes, Healthy Volunteers, Electrophysiology, Smell, Bioassays and Physiological Analysis, Brain Electrophysiology, Engineering and Technology, Sensory Perception, Female, Cues, Riechstörungen, physiologische Bewertungen, Menthol-Lateralisationstest, Geruchsreizabgabevorrichtungen, Technische Universität Dresden, Publikationsfonds, Research Article, Adult, Adolescent, Imaging Techniques, Neurophysiology, Neuroimaging, Research and Analysis Methods, Sensitivity and Specificity, Sensory Cues, Olfactometry, Humans, ddc:610, Signal to Noise Ratio, Aged, Eucalyptol, lcsh:R, Electrophysiological Techniques, Organisms, Peas, Biology and Life Sciences, Cyclohexanols, Olfactory Perception, Case-Control Studies, Signal Processing, Monoterpenes, lcsh:Q, Clinical Medicine, Neuroscience
Abstract

Objectives The objective of the present study was to investigate the usefulness of time-frequency analysis (TFA) of olfactory-induced EEG change with a low-cost, portable olfactometer in the clinical investigation of smell function. Materials & methods A total of 78 volunteers participated. The study was composed of three parts where olfactory stimuli were presented using a custom-built olfactometer. Part I was designed to optimize the stimulus as well as the recording conditions. In part II EEG-power changes after olfactory/trigeminal stimulation were compared between healthy participants and patients with olfactory impairment. In Part III the test-retest reliability of the method was evaluated in healthy subjects. Results Part I indicated that the most effective paradigm for stimulus presentation was cued stimulus, with an interstimulus interval of 18-20s at a stimulus duration of 1000ms with each stimulus quality presented 60 times in blocks of 20 stimuli each. In Part II we found that central processing of olfactory stimuli analyzed by TFA differed significantly between healthy controls and patients even when controlling for age. It was possible to reliably distinguish patients with olfactory impairment from healthy individuals at a high degree of accuracy (healthy controls vs anosmic patients: sensitivity 75%; specificity 89%). In addition we could show a good test-retest reliability of TFA of chemosensory induced EEG-power changes in Part III. Conclusions Central processing of olfactory stimuli analyzed by TFA reliably distinguishes patients with olfactory impairment from healthy individuals at a high degree of accuracy. Importantly this can be achieved with a simple olfactometer.

Published
2017

19. Impact of Chemotherapy for Childhood Leukemia on Brain Morphology and Function

Author

Genschaft, Marina, primary, Huebner, Thomas, additional, Plessow, Franziska, additional, Ikonomidou, Vasiliki N., additional, Abolmaali, Nasreddin, additional, Krone, Franziska, additional, Hoffmann, Andre, additional, Holfeld, Elisabeth, additional, Vorwerk, Peter, additional, Kramm, Christof, additional, Gruhn, Bernd, additional, Koustenis, Elisabeth, additional, Hernaiz-Driever, Pablo, additional, Mandal, Rakesh, additional, Suttorp, Meinolf, additional, Hummel, Thomas, additional, Ikonomidou, Chrysanthy, additional, Kirschbaum, Clemens, additional, and Smolka, Michael N., additional

Published
2013
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31. Linkage between Increased Nociception and Olfaction via a SCN9A Haplotype.

Author

Heimann, Dirk, Lötsch, Jörn, Hummel, Thomas, Doehring, Alexandra, and Oertel, Bruno G.

Subjects
LINKAGE (Genetics), NOCICEPTIVE pain, SMELL, HAPLOTYPES, GENETIC mutation, SENSORY perception, ION channels
Abstract

Background and Aims: Mutations reducing the function of Nav1.7 sodium channels entail diminished pain perception and olfactory acuity, suggesting a link between nociception and olfaction at ion channel level. We hypothesized that if such link exists, it should work in both directions and gain-of-function Nav1.7 mutations known to be associated with increased pain perception should also increase olfactory acuity. Methods: SCN9A variants were assessed known to enhance pain perception and found more frequently in the average population. Specifically, carriers of SCN9A variants rs41268673C>A (P610T; n = 14) or rs6746030C>T (R1150W; n = 21) were compared with non-carriers (n = 40). Olfactory function was quantified by assessing odor threshold, odor discrimination and odor identification using an established olfactory test. Nociception was assessed by measuring pain thresholds to experimental nociceptive stimuli (punctate and blunt mechanical pressure, heat and electrical stimuli). Results: The number of carried alleles of the non-mutated SCN9A haplotype rs41268673C/rs6746030C was significantly associated with the comparatively highest olfactory threshold (0 alleles: threshold at phenylethylethanol dilution step 12 of 16 (n = 1), 1 allele: 10.6±2.6 (n = 34), 2 alleles: 9.5±2.1 (n = 40)). The same SCN9A haplotype determined the pain threshold to blunt pressure stimuli (0 alleles: 21.1 N/m2, 1 allele: 29.8±10.4 N/m2, 2 alleles: 33.5±10.2 N/m2). Conclusions: The findings established a working link between nociception and olfaction via Nav1.7 in the gain-of-function direction. Hence, together with the known reduced olfaction and pain in loss-of-function mutations, a bidirectional genetic functional association between nociception and olfaction exists at Nav1.7 level. [ABSTRACT FROM AUTHOR]

Published
2013
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