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4. Genome wide profiling in oral squamous cell carcinoma identifies a four genetic marker signature of prognostic significance

Author

Vincent-Chong, Vui King, primary, Salahshourifar, Iman, additional, Woo, Kar Mun, additional, Anwar, Arif, additional, Razali, Rozaimi, additional, Gudimella, Ranganath, additional, Rahman, Zainal Ariff Abdul, additional, Ismail, Siti Mazlipah, additional, Kallarakkal, Thomas George, additional, Ramanathan, Anand, additional, Wan Mustafa, Wan Mahadzir, additional, Abraham, Mannil Thomas, additional, Tay, Keng Kiong, additional, and Zain, Rosnah Binti, additional

Published
2017
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6. Genome Wide Analysis of Chromosomal Alterations in Oral Squamous Cell Carcinomas Revealed over Expression of MGAM and ADAM9

Author

Vincent-Chong, Vui King, primary, Anwar, Arif, additional, Karen-Ng, Lee Peng, additional, Cheong, Sok Ching, additional, Yang, Yi-Hsin, additional, Pradeep, Padmaja Jayaprasad, additional, Rahman, Zainal Ariff Abdul, additional, Ismail, Siti Mazlipah, additional, Zaini, Zuraiza Mohamad, additional, Prepageran, Narayanan, additional, Kallarakkal, Thomas George, additional, Ramanathan, Anand, additional, Mohayadi, Nur Aaina Binti Mohd, additional, Rosli, Nurul Shielawati Binti Mohamed, additional, Mustafa, Wan Mahadzir Wan, additional, Abraham, Mannil Thomas, additional, Tay, Keng Kiong, additional, and Zain, Rosnah Binti, additional

Published
2013
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7. CD4+CD25hiCD127low Regulatory T Cells Are Increased in Oral Squamous Cell Carcinoma Patients.

Author

Lim, Kue Peng, Chun, Nicole Ai Leng, Ismail, Siti Mazlipah, Abraham, Mannil Thomas, Yusoff, Mohd Nury, Zain, Rosnah Binti, Ngeow, Wei Cheong, Ponniah, Sathibalan, and Cheong, Sok Ching

Subjects
CD4 antigen, CD25 antigen, T cells, SQUAMOUS cell carcinoma, ORAL cancer, CANCER invasiveness, PATIENTS
Abstract

Regulatory T cells (Tregs), a subset of CD4+ T cells plays a pivotal role in regulating the immune system. An increase in Treg numbers enables cancer progression by dampening the immune system and allowing tumor cells to evade immune detection and destruction. An increase in Treg numbers and expression of inhibitory cytokines including TGF-β and IL-10 are mechanisms by which Tregs exert their immune suppressive function. However, the presence of Tregs and inhibitory cytokines in oral cancer patients is still unclear. In this study, the presence of circulating Tregs in 39 oral cancer patients and 24 healthy donors was examined by studying the presence of the CD4+CD25hiCD127low cell population in their peripheral blood mononuclear cells using flow cytometry. Serum levels of TGF-β and IL-10 were measured by ELISA. T cell subsets of OSCC patients were found to differ significantly from healthy donors where a decrease in CD8+ cytotoxic T cells and an increase in Tregs (CD4+CD25hiCD127low) were observed. Further, the ratio of CD8+ T cells/Tregs was also decreased in patients compared to healthy donors. The presence of Tregs was accompanied by a decrease in IL-10 but not TGF-β secretion in OSCC patients when compared to donors; in addition, the analysis also revealed that an increased presence of Tregs was accompanied by better patient survival. Amongst OSCC patients, smokers had significantly higher levels of TGF-β. It is apparent that the immune system is compromised in OSCC patients and the characterization of the Treg subpopulation could form a basis for improving our understanding of the perturbations in the immune system that occur during OSCC tumorigenesis. [ABSTRACT FROM AUTHOR]

Published
2014
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