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As China's second-largest source of greenhouse gas emissions, agriculture is essential to achieving the goal of "carbon peak" and "carbon neutrality." Based on the measurement of agricultural carbon emissions (ACE) and agricultural carbon intensity (ACI) in 19 regions along the Yangtze River Economic Belt (YEB) and Yellow River Basin (YRB) in China from 2001 to 2020, this paper first uses the super-efficiency SBM model to measure ACE efficiency from static and dynamic perspectives. Then, the coupling coordination degree (CCD) between ACE efficiency and green finance in each region of the two basins is explored. Finally, Grey Relation Analysis (GRA) is used to obtain the influencing factors of CCD. The following conclusions are drawn: (1) The ACE in the YEB is almost twice that of the YRB. The ACE of the two basins generally experienced a trend of first growth and then declined, but the peak time was different. The ACI of the two basins showed a trend of continuous decline, and the decline rate of the YRB was faster. (2) The ACE efficiency of the two basins showed an overall upward trend, and the growth degree of different regions was vastly different. From the factor decomposition, the technological progress (TP) of the two basins significantly impacts the total factor productivity (TFP). (3) The CCD of ACE efficiency and green finance in the two basins increased from near imbalance to barely coordination level, and the CCD of the YEB increased slightly faster. The CCD of the two basins has a spatial difference of "downstream > midstream > upstream." (4) Among the influencing factors of the CCD of the two systems, the influencing degree of the factors is as follows from large to small: quality of human capital, level of economic development, government regulation, scientific and technological innovation ability.

Modulation of the autonomic nervous system (ANS) has already been demonstrated to display antiarrhythmic effects in patients and animals with MI. In this study, we investigated whether local cardiac denervation has any beneficial effects on ventricular electrical stability and cardiac function in the chronic phase of MI.Twenty-one anesthetized dogs were randomly assigned into the sham-operated, MI and MI-ablation groups, respectively. Four weeks after local cardiac denervation, LSG stimulation was used to induce VPCs and VAs. The ventricular fibrillation threshold (VFT) and the incidence of inducible VPCs were measured with electrophysiological protocol. Cardiac innervation was determined with immunohistochemical staining of growth associated protein-43 (GAP43) and tyrosine hydroxylase (TH). The global cardiac and regional ventricular function was evaluated with doppler echocardiography in this study.Four weeks after operation, the incidence of inducible VPC and VF in MI-ablation group were significantly reduced compared to the MI dogs (p

While significant progress has been made in understanding the anti-inflammatory and anti-proliferative effects of the natural diterpenoid component Oridonin on tumor cells, little is known about its effect on tumor angiogenesis or metastasis and on the underlying molecular mechanisms. In this study, Oridonin significantly suppressed human umbilical vascular endothelial cells (HUVECs) proliferation, migration, and apillary-like structure formation in vitro. Using aortic ring assay and mouse corneal angiogenesis model, we found that Oridonin inhibited angiogenesis ex vivo and in vivo. In our animal experiments, Oridonin impeded tumor growth and metastasis. Immunohistochemistry analysis further revealed that the expression of CD31 and vWF protein in xenografts was remarkably decreased by the Oridonin. Furthermore, Oridonin reinforced endothelial cell-cell junction and impaired breast cancer cell transendothelial migration. Mechanistically, Oridonin not only down-regulated Jagged2 expression and Notch1 activity but also decreased the expression of their target genes. In conclusion, our results demonstrated an original role of Oridonin in inhibiting tumor angiogenesis and propose a mechanism. This study also provides new evidence supporting the central role of Notch in tumor angiogenesis and suggests that Oridonin could be a potential drug candidate for angiogenesis related diseases.