1. Serum albumin and body weight as biomarkers for the antemortem identification of bone and gastrointestinal disease in the common marmoset
- Author
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Gillian C. Shaw, Nathaniel P. Sotuyo, Erik J. Olson, Victoria K. Baxter, Robert J. Adams, M. Christine Zink, Joseph L. Mankowski, Eric K. Hutchinson, Cathy S. Carlson, and Kelly A. Metcalf Pate
- Subjects
Pathology ,medicine.medical_specialty ,endocrine system ,Bone disease ,040301 veterinary sciences ,Gastrointestinal Diseases ,Serum albumin ,lcsh:Medicine ,Physiology ,Parathyroid hormone ,Disease ,Animal Diseases ,0403 veterinary science ,03 medical and health sciences ,biology.animal ,medicine ,Animals ,lcsh:Science ,Serum Albumin ,030304 developmental biology ,0303 health sciences ,Multidisciplinary ,medicine.diagnostic_test ,biology ,business.industry ,lcsh:R ,Body Weight ,Complete blood count ,Marmoset ,Callithrix ,04 agricultural and veterinary sciences ,Syndrome ,medicine.disease ,biology.organism_classification ,3. Good health ,Radiography ,Gastrointestinal disease ,Parathyroid Hormone ,biology.protein ,lcsh:Q ,Bone Diseases ,business ,Biomarkers ,Research Article - Abstract
The increasing use of the common marmoset (Callithrix jacchus) in research makes it important to diagnose spontaneous disease that may confound experimental studies. Bone disease and gastrointestinal disease are two major causes of morbidity and mortality in captive marmosets, but currently no effective antemortem tests are available to identify affected animals prior to the terminal stage of disease. In this study we propose that bone disease and gastrointestinal disease are associated disease entities in marmosets and aim to establish the efficacy of several economical antemortem tests in identifying and predicting disease. Tissues from marmosets were examined to define affected animals and unaffected controls. Complete blood count, serum chemistry values, body weight, quantitative radiographs, and tissue-specific biochemical markers were evaluated as candidate biomarkers for disease. Bone and gastrointestinal disease were associated, with marmosets being over seven times more likely to have either concurrent bone and gastrointestinal disease or neither disease as opposed to lesions in only one organ system. When used in tandem, serum albumin
- Published
- 2013