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3. Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients

Author

Elbere, Ilze, primary, Silamikelis, Ivars, additional, Dindune, Ilze Izabella, additional, Kalnina, Ineta, additional, Ustinova, Monta, additional, Zaharenko, Linda, additional, Silamikele, Laila, additional, Rovite, Vita, additional, Gudra, Dita, additional, Konrade, Ilze, additional, Sokolovska, Jelizaveta, additional, Pirags, Valdis, additional, and Klovins, Janis, additional

Published
2020
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8. A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe

Author

Khrunin, Andrey V., primary, Khokhrin, Denis V., additional, Filippova, Irina N., additional, Esko, Tõnu, additional, Nelis, Mari, additional, Bebyakova, Natalia A., additional, Bolotova, Natalia L., additional, Klovins, Janis, additional, Nikitina-Zake, Liene, additional, Rehnström, Karola, additional, Ripatti, Samuli, additional, Schreiber, Stefan, additional, Franke, Andre, additional, Macek, Milan, additional, Krulišová, Veronika, additional, Lubinski, Jan, additional, Metspalu, Andres, additional, and Limborska, Svetlana A., additional

Published
2013
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9. Correction: Genetic Structure of Europeans: A View from the North–East

Author

Nelis, Mari, primary, Esko, Tõnu, additional, Mägi, Reedik, additional, Zimprich, Fritz, additional, Zimprich, Alexander, additional, Toncheva, Draga, additional, Karachanak, Sena, additional, Piskáčková, Tereza, additional, Balaščák, Ivan, additional, Peltonen, Leena, additional, Jakkula, Eveliina, additional, Rehnström, Karola, additional, Lathrop, Mark, additional, Heath, Simon, additional, Galan, Pilar, additional, Schreiber, Stefan, additional, Meitinger, Thomas, additional, Pfeufer, Arne, additional, Wichmann, H-Erich, additional, Melegh, Béla, additional, Polgár, Noémi, additional, Toniolo, Daniela, additional, Gasparini, Paolo, additional, D'Adamo, Pio, additional, Klovins, Janis, additional, Nikitina-Zake, Liene, additional, Kučinskas, Vaidutis, additional, Kasnauskienė, Jūratė, additional, Lubinski, Jan, additional, Debniak, Tadeusz, additional, Limborska, Svetlana, additional, Khrunin, Andrey, additional, Estivill, Xavier, additional, Rabionet, Raquel, additional, Marsal, Sara, additional, Julià, Antonio, additional, Antonarakis, Stylianos E., additional, Deutsch, Samuel, additional, Borel, Christelle, additional, Attar, Homa, additional, Gagnebin, Maryline, additional, Macek, Milan, additional, Krawczak, Michael, additional, Remm, Maido, additional, and Metspalu, Andres, additional

Published
2010
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10. Genetic Structure of Europeans: A View from the North–East

Author

Nelis, Mari, primary, Esko, Tõnu, additional, Mägi, Reedik, additional, Zimprich, Fritz, additional, Zimprich, Alexander, additional, Toncheva, Draga, additional, Karachanak, Sena, additional, Piskáčková, Tereza, additional, Balaščák, Ivan, additional, Peltonen, Leena, additional, Jakkula, Eveliina, additional, Rehnström, Karola, additional, Lathrop, Mark, additional, Heath, Simon, additional, Galan, Pilar, additional, Schreiber, Stefan, additional, Meitinger, Thomas, additional, Pfeufer, Arne, additional, Wichmann, H-Erich, additional, Melegh, Béla, additional, Polgár, Noémi, additional, Toniolo, Daniela, additional, Gasparini, Paolo, additional, D'Adamo, Pio, additional, Klovins, Janis, additional, Nikitina-Zake, Liene, additional, Kučinskas, Vaidutis, additional, Kasnauskienė, Jūratė, additional, Lubinski, Jan, additional, Debniak, Tadeusz, additional, Limborska, Svetlana, additional, Khrunin, Andrey, additional, Estivill, Xavier, additional, Rabionet, Raquel, additional, Marsal, Sara, additional, Julià, Antonio, additional, Antonarakis, Stylianos E., additional, Deutsch, Samuel, additional, Borel, Christelle, additional, Attar, Homa, additional, Gagnebin, Maryline, additional, Macek, Milan, additional, Krawczak, Michael, additional, Remm, Maido, additional, and Metspalu, Andres, additional

Published
2009
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11. The Association of Common SNPs and Haplotypes in CETP Gene with HDL Cholesterol Levels in Latvian Population

Author

Radovica, Ilze, Fridmanis, Davids, Vaivade, Iveta, Nikitina-Zake, Liene, and Klovins, Janis

Subjects
SINGLE nucleotide polymorphisms, HAPLOTYPES, CHOLESTERYL ester transfer protein, HIGH-density lipoprotein receptors, GENETIC regulation, COMPARATIVE studies, LATVIANS
Abstract

The heritability of high-density lipoprotein cholesterol (HDL-C) level is estimated at approximately 50%. Recent genome-wide association studies have identified genes involved in regulation of high-density lipoprotein cholesterol (HDL-C) levels. The precise genetic profile determining heritability of HDL-C however are far from complete and there is substantial room for further characterization of genetic profiles influencing blood lipid levels. Here we report an association study comparing the distribution of 139 SNPs from more than 30 genes between groups that represent extreme ends of HDL-C distribution. We genotyped 704 individuals that were selected from Genome Database of Latvian Population. 10 SNPs from CETP gene showed convincing association with low HDL-C levels (rs1800775, rs3764261, rs173539, rs9939224, rs711752, rs708272, rs7203984, rs7205804, rs11076175 and rs9929488) while 34 SNPs from 10 genes were nominally associated (p<0.05) with HDL-C levels. We have also identified haplotypes from CETP with distinct effects on determination of HDL-C levels. Our conclusion: So far the SNPs in CETP gene are identified as the most common genetic factor influencing HDL-C levels in the representative sample from Latvian population. [ABSTRACT FROM AUTHOR]

Published
2013
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