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Start Over Author "Kramer, Susanne" Journal plos one
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6. Alterations in DRBD3 Ribonucleoprotein Complexes in Response to Stress in Trypanosoma brucei.

Author

Fernÿndez-Moya, Sandra M., García-Pérez, Angélica, Kramer, Susanne, Carrington, Mark, and Estévez, Antonio M.

Subjects
CELL cycle, CYTOLOGY, HUMAN genetics, MESSENGER RNA, CELL division, HUMAN cell cycle
Abstract

Regulation of RNA polymerase II transcription initiation is apparently absent in trypanosomes. Instead, these eukaryotes control gene expression mainly at the post-transcriptional level. Regulation is exerted through the action of numerous RNAbinding proteins that modulate mRNA processing, turnover, translation and localization. In this work we show that the RNAbinding protein DRBD3 resides in the cytoplasm, but localizes to the nucleus upon oxidative challenge and to stress granules under starvation conditions. DRBD3 associates with other proteins to form a complex, the composition of which is altered by cellular stress. Interestingly, target mRNAs remain bound to DRBD3 under stress conditions. Our results suggest that DRBD3 transports regulated mRNAs within the cell in the form of ribonucleoprotein complexes that are remodeled in response to environmental cues. [ABSTRACT FROM AUTHOR]

Published
2012
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