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Your search keyword '"Kraneveld, Aletta D."' showing total 7 results
Start Over Author "Kraneveld, Aletta D." Journal plos one
7 results on '"Kraneveld, Aletta D."'

3. Correction: Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?

Author

Overbeek, Saskia A., primary, Braber, Saskia, additional, Koelink, Pim J., additional, Henricks, Paul A. J., additional, Mortaz, Esmaeil, additional, LoTam Loi, Adele T., additional, Jackson, Patricia L., additional, Garssen, Johan, additional, Wagenaar, Gerry T. M., additional, Timens, Wim, additional, Koenderman, Leo, additional, Blalock, J. Edwin, additional, Kraneveld, Aletta D., additional, and Folkerts, Gert, additional

Published
2013
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5. Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?

Author

Overbeek, Saskia A., primary, Braber, Saskia, additional, Koelink, Pim J., additional, Henricks, Paul A. J., additional, Mortaz, Esmaeil, additional, LoTam Loi, Adele T., additional, Jackson, Patricia L., additional, Garssen, Johan, additional, Wagenaar, Gerry T. M., additional, Timens, Wim, additional, Koenderman, Leo, additional, Blalock, J. Edwin, additional, Kraneveld, Aletta D., additional, and Folkerts, Gert, additional

Published
2013
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7. Bifidobacterium breve Attenuates Murine Dextran Sodium Sulfate-Induced Colitis and Increases Regulatory T Cell Responses.

Author

Zheng, Bin, van Bergenhenegouwen, Jeroen, Overbeek, Saskia, van de Kant, Hendrik J. G., Garssen, Johan, Folkerts, Gert, Vos, Paul, Morgan, Mary E., and Kraneveld, Aletta D.

Subjects
BIFIDOBACTERIUM breve, DEXTRAN, SODIUM sulfate, COLITIS, T cells, PROBIOTICS, PHYSIOLOGY
Abstract

While some probiotics have shown beneficial effects on preventing or treating colitis development, others have shown no effects. In this study, we have assessed the immunomodulating effects of two probiotic strains, Lactobacillus rhamnosus (L. rhamnosus) and Bifidobacterium breve (B. breve) on T cell polarization in vitro, using human peripheral blood mononuclear cells (PBMC), and in vivo, using murine dextran sodium sulfate (DSS) colitis model. With respect to the latter, the mRNA expression of T cell subset-associated transcription factors and cytokines in the colon was measured and the T helper type (Th) 17 and regulatory T cell (Treg) subsets were determined in the Peyer's patches. Both L. rhamnosus and B. breve incubations in vitro reduced Th17 and increased Th2 cell subsets in human PBMCs. In addition, B. breve incubation was also able to reduce Th1 and increase Treg cell subsets in contrast to L. rhamnosus. In vivo intervention with B. breve, but not L. rhamnosus, significantly attenuated the severity of DSS-induced colitis. In DSS-treated C57BL/6 mice, intervention with B. breve increased the expression of mRNA encoding for Th2- and Treg-associated cytokines in the distal colon. In addition, intervention with B. breve led to increases of Treg and decreases of Th17 cell subsets in Peyer's patches of DSS-treated mice. B. breve modulates T cell polarization towards Th2 and Treg cell-associated responses in vitro and in vivo. In vivo B. breve intervention ameliorates DSS-induced colitis symptoms and this protective effect may mediated by its effects on the T-cell composition. [ABSTRACT FROM AUTHOR]

Published
2014
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