1. HuVarBase: A human variant database with comprehensive information at gene and protein levels
- Author
-
M. Michael Gromiha, A. Kulandaisamy, S. Binny Priya, and Kaliappan Ganesan
- Subjects
Mutant ,computer.software_genre ,Genome ,Biochemistry ,Database and Informatics Methods ,Protein Structure Databases ,0302 clinical medicine ,Protein structure ,Databases, Genetic ,Macromolecular Structure Analysis ,Database Searching ,Peptide sequence ,Protein secondary structure ,0303 health sciences ,Multidisciplinary ,Database ,Chromosome Biology ,Genomics ,Genomic Databases ,Medicine ,Sequence Analysis ,Research Article ,Protein Structure ,Chromosome Structure and Function ,Bioinformatics ,Science ,Protein domain ,Sequence Databases ,Biology ,Research and Analysis Methods ,Chromosomes ,03 medical and health sciences ,Protein Domains ,Genetic variation ,Genetics ,Humans ,Gene ,Molecular Biology ,030304 developmental biology ,Genome, Human ,Genetic Variation ,Proteins ,Biology and Life Sciences ,Computational Biology ,Cell Biology ,Genome Analysis ,Biological Databases ,Mutation Databases ,Mutation ,computer ,030217 neurology & neurosurgery - Abstract
Human variant databases could be better exploited if the variant data available in multiple resources is integrated in a single comprehensive resource along with sequence and structural features. Such integration would improve the analyses of variants for disease prediction, prevention or treatment. The HuVarBase (HUmanVARiantdataBASE) assimilates publicly available human variant data at protein level and gene level into a comprehensive resource. Protein level data such as amino acid sequence, secondary structure of the mutant residue, domain, function, subcellular location and post-translational modification are integrated with gene level data such as gene name, chromosome number & genome position, DNA mutation, mutation type origin and rs ID number. Disease class has been added for the disease causing variants. The database is publicly available at https://www.iitm.ac.in/bioinfo/huvarbase. A total of 774,863 variant records, integrated in the HuVarBase, can be searched with options to display, visualize and download the results.
- Published
- 2018