1. Dependence of Brain Intravoxel Incoherent Motion Perfusion Parameters on the Cardiac Cycle.
- Author
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Federau, Christian, Hagmann, Patric, Maeder, Philippe, Müller, Markus, Meuli, Reto, Stuber, Matthias, and O’Brien, Kieran
- Subjects
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PERFUSION , *HEART beat , *MAGNETIC resonance imaging of the brain , *BRAIN physiology , *BLOOD circulation , *BLOOD vessels , *MEDICAL physics - Abstract
Measurement of microvascular perfusion with Intravoxel Incoherent Motion (IVIM) MRI is gaining interest. Yet, the physiological influences on the IVIM perfusion parameters (“pseudo-diffusion” coefficient D*, perfusion fraction f, and flow related parameter fD*) remain insufficiently characterized. In this article, we hypothesize that D* and fD*, which depend on blood speed, should vary during the cardiac cycle. We extended the IVIM model to include time dependence of D* = D*(t), and demonstrate in the healthy human brain that both parameters D* and fD* are significantly larger during systole than diastole, while the diffusion coefficient D and f do not vary significantly. The results non-invasively demonstrate the pulsatility of the brain’s microvasculature. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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