Search

Your search keyword '"McClure, Myra O."' showing total 9 results
Start Over Author "McClure, Myra O." Journal plos one
9 results on '"McClure, Myra O."'

1. Correction: Sera selected from national STI surveillance system shows Chlamydia trachomatis PgP3 antibody correlates with time since infection and number of previous infections

Author

Blomquist, Paula B., primary, Migchelsen, Stephanie J., additional, Wills, Gillian, additional, McClure, Eleanor, additional, Ades, Anthony E., additional, Kounali, Daphne, additional, Dunbar, J. Kevin, additional, McClure, Myra O., additional, Soldan, Kate, additional, Woodhall, Sarah C., additional, and Horner, Patrick, additional

Published
2019
Full Text
View/download PDF

2. Sera selected from national STI surveillance system shows Chlamydia trachomatis PgP3 antibody correlates with time since infection and number of previous infections

Author

Blomquist, Paula B., primary, Mighelsen, Stephanie J., additional, Wills, Gillian, additional, McClure, Eleanor, additional, Ades, Anthony E., additional, Kounali, Daphne, additional, Dunbar, J. Kevin, additional, McClure, Myra O., additional, Soldan, Kate, additional, Woodhall, Sarah C., additional, and Horner, Patrick, additional

Published
2018
Full Text
View/download PDF

3. Chlamydia trachomatis Pgp3 Antibody Population Seroprevalence before and during an Era of Widespread Opportunistic Chlamydia Screening in England (1994-2012)

Author

Woodhall, Sarah C, Wills, Gillian S, Horner, Paddy J, Craig, Rachel, Mindell, Jennifer S, Murphy, Gary, McClure, Myra O, Soldan, Kate, Nardone, Anthony, and Johnson, Anne M

Subjects
lcsh:R, lcsh:Medicine, lcsh:Q, lcsh:Science
Abstract

BACKGROUNDOpportunistic chlamydia screening of METHODSAnonymised sera from participants in the nationally-representative Health Surveys for England (HSE) were tested for C.trachomatis antibodies using two novel Pgp3 enzyme-linked immunosorbent assays (ELISAs) as a marker of past infection. Determinants of being seropositive were explored using logistic regression among 16-44 year-old women and men in 2010 and 2012 (years when sexual behaviour questions were included in the survey) (n = 1,402 women; 1,119 men). Seroprevalence trends among 16-24 year-old women (n = 3,361) were investigated over ten time points from 1994-2012.RESULTSIn HSE2010/2012, Pgp3 seroprevalence among 16-44 year-olds was 24.4% (95%CI 22.0-27.1) in women and 13.9% (11.8-16.2) in men. Seroprevalence increased with age (up to 33.5% [27.5-40.2] in 30-34 year-old women, 18.7% [13.4-25.6] in 35-39 year-old men); years since first sex; number of lifetime sexual partners; and younger age at first sex. 76.7% of seropositive 16-24 year-olds had never been diagnosed with chlamydia. Among 16-24 year-old women, a non-significant decline in seroprevalence was observed from 2008-2012 (prevalence ratio per year: 0.94 [0.84-1.05]).CONCLUSIONOur application of Pgp3 ELISAs demonstrates a high lifetime risk of chlamydia infection among women and a large proportion of undiagnosed infections. A decrease in age-specific cumulative incidence following national implementation of opportunistic chlamydia screening has not yet been demonstrated. We propose these assays be used to assess impact of chlamydia control programmes.

Published
2017

9. C. trachomatis pgp3 Antibody Prevalence in Young Women in England, 1993–2010.

Author

Horner, Paddy, Soldan, Kate, Vieira, Sueli M., Wills, Gillian S., Woodhall, Sarah C., Pebody, Richard, Nardone, Anthony, Stanford, Elaine, and McClure, Myra O.

Subjects
CHLAMYDIA, IMMUNOGLOBULINS, DISEASE prevalence, YOUNG women, WOMEN, COMMUNICABLE diseases, PUBLIC health, SEXUALLY transmitted diseases
Abstract

Seroepidemiology of chlamydia can offer study opportunities and insights into cumulative risk of exposure that may contribute to monitoring the frequency of, and control of, genital chlamydia–the most commonly diagnosed STI in England. We undertook retrospective anonymous population-based cross-sectional surveys using an indirect IgG ELISA for chlamydia Pgp3 antibody. Sera from 4,732 women aged 17–24 years were tested. Samples were taken at 3-yearly intervals between 1993 and 2002, a period during which other data suggest chlamydia transmission may have been increasing, and from each year between 2007 and 2010. Seroprevalence increased in 17–24 year olds over time between 1993 and 2002. Between 2007 and 2010, age-standardised seroprevalence among 17–24 year olds decreased from 20% (95% CI: 17–23) to 15% (95%CI 12–17) (p = 0.0001). The biggest drop was among 20 to 21 year olds, where seroprevalence decreased from 21% in 2007 to 9% in 2010 (p = 0.002). These seroprevalence data reflect some known features of the epidemiology of chlamydia infection, and show that exposure to antibody-inducing chlamydia infection has declined in recent years. This decline was concurrent with increasing rates of screening for asymptomatic chlamydia. Serology should be explored further as a tool for evaluation of chlamydia control, including chlamydia screening programmes. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results