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3. COVID-19 outbreak in long-term care facilities from Spain. Many lessons to learn

Author

Mas Romero, Marta, primary, Avendaño Céspedes, Almudena, additional, Tabernero Sahuquillo, María Teresa, additional, Cortés Zamora, Elisa Belén, additional, Gómez Ballesteros, Cristina, additional, Sánchez-Flor Alfaro, Victoria, additional, López Bru, Rita, additional, López Utiel, Melisa, additional, Celaya Cifuentes, Sara, additional, Peña Longobardo, Luz María, additional, Murillo Romero, Antonio, additional, Plaza Carmona, Laura, additional, Gil García, Borja, additional, Pérez Fernández-Rius, Ana, additional, Alcantud Córcoles, Rubén, additional, Roldán García, Belén, additional, Romero Rizos, Luis, additional, Sánchez Jurado, Pedro Manuel, additional, León Ortiz, Matilde, additional, Atienzar Núñez, Pilar, additional, Noguerón García, Alicia, additional, Ruiz García, María Fe, additional, García Molina, Rafael, additional, Estrella Cazalla, Juan de Dios, additional, Oliva Moreno, Juan, additional, and Abizanda, Pedro, additional

Published
2020
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8. Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats

Author

Martín-Fernández, Beatriz, primary, Rubio-Navarro, Alfonso, additional, Cortegano, Isabel, additional, Ballesteros, Sandra, additional, Alía, Mario, additional, Cannata-Ortiz, Pablo, additional, Olivares-Álvaro, Elena, additional, Egido, Jesús, additional, de Andrés, Belén, additional, Gaspar, María Luisa, additional, de las Heras, Natalia, additional, Lahera, Vicente, additional, and Moreno, Juan Antonio, additional

Published
2016
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9. Haematuria Increases Progression of Advanced Proteinuric Kidney Disease

Author

Yuste, Claudia, primary, Rubio-Navarro, Alfonso, additional, Barraca, Daniel, additional, Aragoncillo, Inés, additional, Vega, Almudena, additional, Abad, Soraya, additional, Santos, Alba, additional, Macias, Nicolás, additional, Mahillo, Ignacio, additional, Gutiérrez, Eduardo, additional, Praga, Manuel, additional, Egido, Jesús, additional, López-Gómez, Juan Manuel, additional, and Moreno, Juan Antonio, additional

Published
2015
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10. Reduced sTWEAK and Increased sCD163 Levels in HIV-Infected Patients: Modulation by Antiretroviral Treatment, HIV Replication and HCV Co-Infection

Author

Beltrán, Luis M., primary, Muñoz Hernández, Rocío, additional, de Pablo Bernal, Rebeca S., additional, García Morillo, José S., additional, Egido, Jesús, additional, Noval, Manuel Leal, additional, Ferrando-Martinez, Sara, additional, Blanco-Colio, Luis M., additional, Genebat, Miguel, additional, Villar, José R., additional, Moreno-Luna, Rafael, additional, and Moreno, Juan Antonio, additional

Published
2014
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11. Assessing the Effects of Climate on Host-Parasite Interactions: A Comparative Study of European Birds and Their Parasites

Author

Møller, Anders Pape, primary, Merino, Santiago, additional, Soler, Juan José, additional, Antonov, Anton, additional, Badás, Elisa P., additional, Calero-Torralbo, Miguel A., additional, de Lope, Florentino, additional, Eeva, Tapio, additional, Figuerola, Jordi, additional, Flensted-Jensen, Einar, additional, Garamszegi, Laszlo Z., additional, González-Braojos, Sonia, additional, Gwinner, Helga, additional, Hanssen, Sveinn Are, additional, Heylen, Dieter, additional, Ilmonen, Petteri, additional, Klarborg, Kurt, additional, Korpimäki, Erkki, additional, Martínez, Javier, additional, Martínez-de la Puente, Josue, additional, Marzal, Alfonso, additional, Matthysen, Erik, additional, Matyjasiak, Piotr, additional, Molina-Morales, Mercedes, additional, Moreno, Juan, additional, Mousseau, Timothy A., additional, Nielsen, Jan Tøttrup, additional, Pap, Péter László, additional, Rivero-de Aguilar, Juan, additional, Shurulinkov, Peter, additional, Slagsvold, Tore, additional, Szép, Tibor, additional, Szöllősi, Eszter, additional, Török, Janos, additional, Vaclav, Radovan, additional, Valera, Francisco, additional, and Ziane, Nadia, additional

Published
2013
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13. Gamete Therapeutics: Recombinant Protein Adsorption by Sperm for Increasing Fertility via Artificial Insemination

Author

Alvarez-Gallardo, Horacio, primary, Kjelland, Michael E., additional, Moreno, Juan F., additional, Welsh, Thomas H., additional, Randel, Ronald D., additional, Lammoglia, Miguel A., additional, Pérez-Martínez, Mario, additional, Lara-Sagahón, Alma V., additional, Esperón-Sumano, A. Enrique, additional, and Romo, Salvador, additional

Published
2013
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15. Proteomic Analyses Reveal High Expression of Decorin and Endoplasmin (HSP90B1) Are Associated with Breast Cancer Metastasis and Decreased Survival

Author

Cawthorn, Thomas R., primary, Moreno, Juan C., additional, Dharsee, Moyez, additional, Tran-Thanh, Danh, additional, Ackloo, Suzanne, additional, Zhu, Pei Hong, additional, Sardana, Girish, additional, Chen, Jian, additional, Kupchak, Peter, additional, Jacks, Lindsay M., additional, Miller, Naomi A., additional, Youngson, Bruce J., additional, Iakovlev, Vladimir, additional, Guidos, Cynthia J., additional, Vallis, Katherine A., additional, Evans, Kenneth R., additional, McCready, David, additional, Leong, Wey L., additional, and Done, Susan J., additional

Published
2012
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16. Geographical Variation in Egg Mass and Egg Content in a Passerine Bird

Author

Ruuskanen, Suvi, primary, Siitari, Heli, additional, Eeva, Tapio, additional, Belskii, Eugen, additional, Järvinen, Antero, additional, Kerimov, Anvar, additional, Krams, Indrikis, additional, Moreno, Juan, additional, Morosinotto, Chiara, additional, Mänd, Raivo, additional, Möstl, Erich, additional, Orell, Markku, additional, Qvarnström, Anna, additional, Salminen, Juha-Pekka, additional, Slater, Fred, additional, Tilgar, Vallo, additional, Visser, Marcel E., additional, Winkel, Wolfgang, additional, Zang, Herwig, additional, and Laaksonen, Toni, additional

Published
2011
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17. Levels of Lycopene β-Cyclase 1 Modulate Carotenoid Gene Expression and Accumulation in Daucus carota.

Author

Moreno, Juan Camilo, Pizarro, Lorena, Fuentes, Paulina, Handford, Michael, Cifuentes, Victor, and Stange, Claudia

Subjects
*LYCOPENE, *CYCLASES, *CAROTENOIDS, *PLANT pigments, *GENE expression, *CARROTS, *BIOACCUMULATION in plants, *PLANT enzymes, *COMPUTATIONAL biology
Abstract

Plant carotenoids are synthesized and accumulated in plastids through a highly regulated pathway. Lycopene β-cyclase (LCYB) is a key enzyme involved directly in the synthesis of α-carotene and β-carotene through the cyclization of lycopene. Carotenoids are produced in both carrot (Daucus carota) leaves and reserve roots, and high amounts of α-carotene and β-carotene accumulate in the latter. In some plant models, the presence of different isoforms of carotenogenic genes is associated with an organ-specific function. D. carota harbors two Lcyb genes, of which DcLcyb1 is expressed in leaves and storage roots during carrot development, correlating with an increase in carotenoid levels. In this work, we show that DcLCYB1 is localized in the plastid and that it is a functional enzyme, as demonstrated by heterologous complementation in Escherichia coli and over expression and post transcriptional gene silencing in carrot. Transgenic plants with higher or reduced levels of DcLcyb1 had incremented or reduced levels of chlorophyll, total carotenoids and β-carotene in leaves and in the storage roots, respectively. In addition, changes in the expression of DcLcyb1 are accompanied by a modulation in the expression of key endogenous carotenogenic genes. Our results indicate that DcLcyb1 does not possess an organ specific function and modulate carotenoid gene expression and accumulation in carrot leaves and storage roots. [ABSTRACT FROM AUTHOR]

Published
2013
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18. Levels of Lycopene β-Cyclase 1 Modulate Carotenoid Gene Expression and Accumulation in Daucus carota.

Author

Moreno, Juan Camilo, Pizarro, Lorena, Fuentes, Paulina, Handford, Michael, Cifuentes, Victor, and Stange, Claudia

Subjects
LYCOPENE, CYCLASES, CAROTENOIDS, PLANT pigments, GENE expression, CARROTS, BIOACCUMULATION in plants, PLANT enzymes, COMPUTATIONAL biology
Abstract

Plant carotenoids are synthesized and accumulated in plastids through a highly regulated pathway. Lycopene β-cyclase (LCYB) is a key enzyme involved directly in the synthesis of α-carotene and β-carotene through the cyclization of lycopene. Carotenoids are produced in both carrot (Daucus carota) leaves and reserve roots, and high amounts of α-carotene and β-carotene accumulate in the latter. In some plant models, the presence of different isoforms of carotenogenic genes is associated with an organ-specific function. D. carota harbors two Lcyb genes, of which DcLcyb1 is expressed in leaves and storage roots during carrot development, correlating with an increase in carotenoid levels. In this work, we show that DcLCYB1 is localized in the plastid and that it is a functional enzyme, as demonstrated by heterologous complementation in Escherichia coli and over expression and post transcriptional gene silencing in carrot. Transgenic plants with higher or reduced levels of DcLcyb1 had incremented or reduced levels of chlorophyll, total carotenoids and β-carotene in leaves and in the storage roots, respectively. In addition, changes in the expression of DcLcyb1 are accompanied by a modulation in the expression of key endogenous carotenogenic genes. Our results indicate that DcLcyb1 does not possess an organ specific function and modulate carotenoid gene expression and accumulation in carrot leaves and storage roots. [ABSTRACT FROM AUTHOR]

Published
2013
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