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4 results on '"Napolitano, Maria"'

2. Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases

Author

Portella, Luigi, primary, Vitale, Rosamaria, additional, De Luca, Stefania, additional, D’Alterio, Crescenzo, additional, Ieranò, Caterina, additional, Napolitano, Maria, additional, Riccio, Anna, additional, Polimeno, Maria Neve, additional, Monfregola, Luca, additional, Barbieri, Antonio, additional, Luciano, Antonio, additional, Ciarmiello, Andrea, additional, Arra, Claudio, additional, Castello, Giuseppe, additional, Amodeo, Pietro, additional, and Scala, Stefania, additional

Published
2013
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3. Multiparametric Analyses of Human PBMCs Loaded Ex Vivo with a Candidate Idiotype Vaccine for HCV-Related Lymphoproliferative Disorders

Author

Petrizzo, Annacarmen, primary, Tornesello, Maria Lina, additional, Napolitano, Maria, additional, D'Alessio, Giovanna, additional, Salomone Megna, Angelo, additional, Dolcetti, Riccardo, additional, De Re, Valli, additional, Wang, Ena, additional, Marincola, Franco M., additional, Buonaguro, Franco M., additional, and Buonaguro, Luigi, additional

Published
2012
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4. Multiparametric Analyses of Human PBMCs Loaded Ex Vivowith a Candidate Idiotype Vaccine for HCV-Related Lymphoproliferative Disorders.

Author

Petrizzo, Annacarmen, Tornesello, Maria Lina, Napolitano, Maria, D'Alessio, Giovanna, Megna, Angelo Salomone, Dolcetti, Riccardo, De Re, Valli, Wang, Ena, Marincola, Franco M., Buonaguro, Franco M., Buonaguro, Luigi, and Ray, Ranjit

Subjects
HEPATITIS C virus, CRYOGLOBULINEMIA, HEPATITIS, B cells, LYMPHOMAS, ANTIGEN presenting cells
Abstract

Hepatitis C virus (HCV) has been identified as one of the major risk factors for type II mixed cryoglobulinemia (MC), during the clinical evolution of chronic hepatitis, which may lead to development of B cell non-Hodgkin's lymphoma (NHL). We have previously shown that the candidate idiotype vaccine, based on the IGKV3-20 light chain protein, is able to induce activation and maturation of circulating antigen presenting cells (APCs) in both HCV-positive and HCV-negative healthy control subjects, with production of Th2-type cytokines. Here, the effect of the recombinant IGKV3-20 protein on human peripheral blood mononuclear cells (PBMCs) from HCV-positive subjects, with known blood levels of cryoglobulins, is shown via gene expression profiling analysis combined to multiparameter flow cytometry and multiplex analyses of cytokines. [ABSTRACT FROM AUTHOR]

Published
2012
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