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1. Effects of medical male circumcision (MC) on plasma HIV viral load in HIV+ HAART naïve men; Rakai, Uganda.

Author

Godfrey Kigozi, Richard Musoke, Nehemiah Kighoma, Stephen Watya, David Serwadda, Fred Nalugoda, Noah Kiwanuka, Fred Wabwire-Mangen, Aaron Tobian, Fredrick Makumbi, Ronald Moses Galiwango, Nelson Sewankambo, James Nkale, Grace Kigozi Nalwoga, Margaret Anyokorit, Tom Lutalo, Ronald Henry Gray, and Maria Joan Wawer

Subjects
Medicine, Science
Abstract

BACKGROUND: Medical male circumcision (MC) of HIV-infected men may increase plasma HIV viral load and place female partners at risk of infection. We assessed the effect of MC on plasma HIV viral load in HIV-infected men in Rakai, Uganda. METHODS: 195 consenting HIV-positive, HAART naïve men aged 12 and above provided blood for plasma HIV viral load testing before surgery and weekly for six weeks and at 2 and 3 months post surgery. Data were also collected on baseline social demographic characteristics and CD4 counts. Change in log10 plasma viral load between baseline and follow-up visits was estimated using paired t tests and multivariate generalized estimating equation (GEE). RESULTS: Of the 195 men, 129 had a CD4 count ≧ 350 and 66 had CD4

Published
2014
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2. Effects of Medical Male Circumcision (MC) on Plasma HIV Viral Load in HIV+ HAART Naïve Men; Rakai, Uganda

Author

Ronald M. Galiwango, Richard Musoke, Ronald H. Gray, Grace Kigozi Nalwoga, Godfrey Kigozi, Tom Lutalo, Fredrick Makumbi, Nehemiah Kighoma, Nelson K. Sewankambo, James Nkale, Stephen Watya, Maria J. Wawer, Aaron A.R. Tobian, David Serwadda, Noah Kiwanuka, Fred Wabwire-Mangen, Fred Nalugoda, and Margaret Anyokorit

Subjects
Male, Viral Diseases, Multivariate analysis, Epidemiology, Human immunodeficiency virus (HIV), lcsh:Medicine, HIV Infections, Plant Science, medicine.disease_cause, Gee, Immunodeficiency Viruses, Antiretroviral Therapy, Highly Active, Blood plasma, Uganda, Prospective Studies, lcsh:Science, Generalized estimating equation, Multidisciplinary, virus diseases, Viral Load, Infectious Diseases, Male circumcision, Medical Microbiology, HIV epidemiology, Research Design, Viral Pathogens, Viral load, Research Article, Adult, medicine.medical_specialty, Clinical Research Design, Urology, HIV prevention, Surgical and Invasive Medical Procedures, Research and Analysis Methods, Microbiology, Infectious Disease Epidemiology, Plasma viral load, Internal medicine, medicine, Humans, Microbial Pathogens, Medicine and health sciences, Preventive medicine, Urologic Infections, business.industry, Genitourinary Infections, Clinical epidemiology, lcsh:R, Biology and Life Sciences, HIV, Plant Pathology, CD4 Lymphocyte Count, Public and occupational health, Circumcision, Male, Immunology, lcsh:Q, business
Abstract

Background Medical male circumcision (MC) of HIV-infected men may increase plasma HIV viral load and place female partners at risk of infection. We assessed the effect of MC on plasma HIV viral load in HIV-infected men in Rakai, Uganda. Methods 195 consenting HIV-positive, HAART naive men aged 12 and above provided blood for plasma HIV viral load testing before surgery and weekly for six weeks and at 2 and 3 months post surgery. Data were also collected on baseline social demographic characteristics and CD4 counts. Change in log10 plasma viral load between baseline and follow-up visits was estimated using paired t tests and multivariate generalized estimating equation (GEE). Results Of the 195 men, 129 had a CD4 count ≧350 and 66 had CD4

Published
2014

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