Search

Your search keyword '"Nishikawa, Shin-Ichi"' showing total 6 results
Start Over Author "Nishikawa, Shin-Ichi" Journal plos one
6 results on '"Nishikawa, Shin-Ichi"'

2. Ectopic Cerebellar Cell Migration Causes Maldevelopment of Purkinje Cells and Abnormal Motor Behaviour in Cxcr4 Null Mice

Author

Huang, Guo-Jen, primary, Edwards, Andrew, additional, Tsai, Cheng-Yu, additional, Lee, Yi-Shin, additional, Peng, Lei, additional, Era, Takumi, additional, Hirabayashi, Yoshio, additional, Tsai, Ching-Yen, additional, Nishikawa, Shin-Ichi, additional, Iwakura, Yoichiro, additional, Chen, Shu-Jen, additional, and Flint, Jonathan, additional

Published
2014
Full Text
View/download PDF

4. Arhgef15 Promotes Retinal Angiogenesis by Mediating VEGF-Induced Cdc42 Activation and Potentiating RhoJ Inactivation in Endothelial Cells

Author

Kusuhara, Sentaro, primary, Fukushima, Yoko, additional, Fukuhara, Shigetomo, additional, Jakt, Lars Martin, additional, Okada, Mitsuhiro, additional, Shimizu, Yuri, additional, Hata, Masayuki, additional, Nishida, Kohji, additional, Negi, Akira, additional, Hirashima, Masanori, additional, Mochizuki, Naoki, additional, Nishikawa, Shin-Ichi, additional, and Uemura, Akiyoshi, additional

Published
2012
Full Text
View/download PDF

6. Ectopic Cerebellar Cell Migration Causes Maldevelopment of Purkinje Cells and Abnormal Motor Behaviour in Cxcr4 Null Mice.

Author

Huang, Guo-Jen, Edwards, Andrew, Tsai, Cheng-Yu, Lee, Yi-Shin, Peng, Lei, Era, Takumi, Hirabayashi, Yoshio, Tsai, Ching-Yen, Nishikawa, Shin-Ichi, Iwakura, Yoichiro, Chen, Shu-Jen, and Flint, Jonathan

Subjects
CEREBELLAR cortex, CELL migration, NEURAL development, PURKINJE cells, LABORATORY mice, MOTOR neurons, CELL culture
Abstract

SDF-1/CXCR4 signalling plays an important role in neuronal cell migration and brain development. However, the impact of CXCR4 deficiency in the postnatal mouse brain is still poorly understood. Here, we demonstrate the importance of CXCR4 on cerebellar development and motor behaviour by conditional inactivation of Cxcr4 in the central nervous system. We found CXCR4 plays a key role in cerebellar development. Its loss leads to defects in Purkinje cell dentritogenesis and axonal projection in vivo but not in cell culture. Transcriptome analysis revealed the most significantly affected pathways in the Cxcr4 deficient developing cerebellum are involved in extra cellular matrix receptor interactions and focal adhesion. Consistent with functional impairment of the cerebellum, Cxcr4 knockout mice have poor coordination and balance performance in skilled motor tests. Together, these results suggest ectopic the migration of granule cells impairs development of Purkinje cells, causes gross cerebellar anatomical disruption and leads to behavioural motor defects in Cxcr4 null mice. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results