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6 results on '"Prudente, Sabrina"'

1. Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation

Author

Haydar, Sara, primary, Grigorescu, Florin, additional, Vintilă, Mădălina, additional, Cogne, Yannick, additional, Lautier, Corinne, additional, Tutuncu, Yildiz, additional, Brun, Jean Frederic, additional, Robine, Jean Marie, additional, Pugeat, Michel, additional, Normand, Christophe, additional, Poucheret, Patrick, additional, Gheorghiu, Monica Livia, additional, Georgescu, Carmen, additional, Badiu, Corin, additional, Băculescu, Nicoleta, additional, Renard, Eric, additional, Ylli, Dorina, additional, Badiou, Stephanie, additional, Sutra, Thibault, additional, Cristol, Jean Paul, additional, Mercier, Jacques, additional, Gomis, Ramon, additional, Macias, Josep Maria, additional, Litvinov, Serghey, additional, Khusnutdinova, Elza, additional, Poiana, Catalina, additional, Pasquali, Renato, additional, Lauro, Davide, additional, Sesti, Giorgio, additional, Prudente, Sabrina, additional, Trischitta, Vincenzo, additional, Tsatsoulis, Agathocles, additional, Abdelhak, Sonia, additional, Barakat, Abdelhamid, additional, Zenati, Akila, additional, Ylli, Agron, additional, Satman, Ilhan, additional, Kanninen, Timo, additional, Rinato, Yves, additional, and Missoni, Sasa, additional

Published
2019
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4. Serum Resistin, Cardiovascular Disease and All-Cause Mortality in Patients with Type 2 Diabetes

Author

Menzaghi, Claudia, primary, Bacci, Simonetta, additional, Salvemini, Lucia, additional, Mendonca, Christine, additional, Palladino, Giuseppe, additional, Fontana, Andrea, additional, De Bonis, Concetta, additional, Marucci, Antonella, additional, Goheen, Elizabeth, additional, Prudente, Sabrina, additional, Morini, Eleonora, additional, Rizza, Stefano, additional, Kanagaki, Alyssa, additional, Fini, Grazia, additional, Mangiacotti, Davide, additional, Federici, Massimo, additional, De Cosmo, Salvatore, additional, Pellegrini, Fabio, additional, Doria, Alessandro, additional, and Trischitta, Vincenzo, additional

Published
2013
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5. ENPP1 Affects Insulin Action and Secretion: Evidences from In Vitro Studies

Author

Di Paola, Rosa, primary, Caporarello, Nunzia, additional, Marucci, Antonella, additional, Dimatteo, Claudia, additional, Iadicicco, Claudia, additional, Del Guerra, Silvia, additional, Prudente, Sabrina, additional, Sudano, Dora, additional, Miele, Claudia, additional, Parrino, Cristina, additional, Piro, Salvatore, additional, Beguinot, Francesco, additional, Marchetti, Piero, additional, Trischitta, Vincenzo, additional, and Frittitta, Lucia, additional

Published
2011
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6. GALNT2 Expression Is Reduced in Patients with Type 2 Diabetes: Possible Role of Hyperglycemia.

Author

Marucci, Antonella, di Mauro, Lazzaro, Menzaghi, Claudia, Prudente, Sabrina, Mangiacotti, Davide, Fini, Grazia, Lotti, Giuseppe, Trischitta, Vincenzo, and Di Paola, Rosa

Subjects
HYPERGLYCEMIA, GENE expression, TYPE 2 diabetes, EPIDEMIOLOGY, MORTALITY, INSULIN resistance, MOLECULAR biology, GENETICS
Abstract

Impaired insulin action plays a major role in the pathogenesis of type 2 diabetes, a chronic metabolic disorder which imposes a tremendous burden to morbidity and mortality worldwide. Unraveling the molecular mechanisms underlying insulin resistance would improve setting up preventive and treatment strategies of type 2 diabetes. Down-regulation of GALNT2, an UDPN-acetyl-alpha-D-galactosamine polypeptideN-acetylgalactosaminyltransferase-2 (ppGalNAc-T2), causes impaired insulin signaling and action in cultured human liver cells. In addition, GALNT2 mRNA levels are down-regulated in liver of spontaneously insulin resistant, diabetic Goto-Kakizaki rats. To investigate the role of GALNT2 in human hyperglycemia, we measured GALNT2 mRNA expression levels in peripheral whole blood cells of 84 non-obese and 46 obese non-diabetic individuals as well as of 98 obese patients with type 2 diabetes. We also measured GALNT2 mRNA expression in human U937 cells cultured under different glucose concentrations. In vivo studies indicated that GALNT2 mRNA levels were significantly reduced from non obese control to obese non diabetic and to obese diabetic individuals (p<0.001). In vitro studies showed that GALNT2 mRNA levels was reduced in U937 cells exposed to high glucose concentrations (i.e. 25 mmol/l glucose) as compared to cells exposed to low glucose concentration (i.e. 5.5 mmol/l glucose +19.5 mmol/l mannitol). In conclusion, our data indicate that GALNT2 is down-regulated in patients with type 2 diabetes and suggest that this association is, at least partly, secondary to hyperglycemia. Further studies are needed to understand whether GALNT2 down-regulation plays a pathogenic role in maintaining and/or aggravating the metabolic abnormalities of diabetic milieu. [ABSTRACT FROM AUTHOR]

Published
2013
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