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Your search keyword '"Reindl, Markus"' showing total 13 results
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13 results on '"Reindl, Markus"'

2. Paroxysmal and unusual symptoms as first clinical manifestation of multiple sclerosis do not indicate benign prognosis—The PaSiMS II study

Author

Bsteh, Gabriel, primary, Ehling, Rainer, additional, Walchhofer, Lisa-Maria, additional, Hegen, Harald, additional, Auer, Michael, additional, Wurth, Sebastian, additional, Di Pauli, Franziska, additional, Wagner, Michaela, additional, Reindl, Markus, additional, Deisenhammer, Florian, additional, and Berger, Thomas, additional

Published
2017
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3. Comparison of diagnostic accuracy of microscopy and flow cytometry in evaluating N-methyl-D-aspartate receptor antibodies in serum using a live cell-based assay

Author

Ramberger, Melanie, Peschl, Patrick, Schanda, Kathrin, Irschick, Regina, Höftberger, Romana, Deisenhammer, Florian, Rostásy, Kevin, Berger, Thomas, Dalmau, Josep, and Reindl, Markus

Subjects
Adult, Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Male, Adolescent, lcsh:R, lcsh:Medicine, Flow Cytometry, Receptors, N-Methyl-D-Aspartate, Sensitivity and Specificity, HEK293 Cells, Microscopy, Fluorescence, Case-Control Studies, Humans, Female, Serologic Tests, lcsh:Q, Child, lcsh:Science, Research Article, Autoantibodies
Abstract

N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune neurological disease, diagnosed by a specific autoantibody against NMDAR. Antibody testing using commercially available cell-based assays (CBA) or immunohistochemistry on rat brain tissue has proven high specificity and sensitivity. Here we compare an immunofluorescence live CBA to a flow cytometry (FACS) based assay to detect NMDAR antibodies by their binding to the surface of HEK293A cells functionally expressing NMDAR. Both assays were first established using a discovery group of 76 individuals and then validated in a group of 32 patients in a blinded manner. In the CBA, 23 of 23 patients with NMDAR encephalitis were positive for NMDAR antibodies and 0 of 85 controls (32 healthy controls and 53 patients with other neurological diseases), resulting in a sensitivity and specificity of 100% (95% confidence intervals (CI) 85.1–100.0 and 95.7–100.0, respectively). The FACS based assay detected NMDAR antibodies in 20 of 23 patients and in 0 of 85 controls. Therefore, with an equally high specificity (95% CI 95.7–100.0) the sensitivity of the FACS based assay was 87% (95% CI 66.4–97.2). Comparing antibody titers from CBA with delta median fluorescence intensities from FACS showed a high concordance (kappa = 0.943, p

Published
2015

6. Neuromyelitis Optica in Austria in 2011: To Bridge the Gap between Neuroepidemiological Research and Practice in a Study Population of 8.4 Million People

Author

Aboul-Enein, Fahmy, primary, Seifert-Held, Thomas, additional, Mader, Simone, additional, Kuenz, Bettina, additional, Lutterotti, Andreas, additional, Rauschka, Helmut, additional, Rommer, Paulus, additional, Leutmezer, Fritz, additional, Vass, Karl, additional, Flamm-Horak, Agathe, additional, Stepansky, Robert, additional, Lang, Wilfried, additional, Fertl, Elisabeth, additional, Schlager, Thomas, additional, Heller, Thomas, additional, Eggers, Christian, additional, Safoschnik, Georg, additional, Fuchs, Siegrid, additional, Kraus, Jörg, additional, Assar, Hamid, additional, Guggenberger, Stefan, additional, Reisz, Martin, additional, Schnabl, Peter, additional, Komposch, Martina, additional, Simschitz, Philipp, additional, Skrobal, Alena, additional, Moser, Alexander, additional, Jeschow, Mario, additional, Stadlbauer, Dorothea, additional, Freimüller, Manfred, additional, Guger, Michael, additional, Schmidegg, Susanne, additional, Franta, Claudia, additional, Weiser, Vera, additional, Koppi, Stefan, additional, Niederkorn-Duft, Margret, additional, Raber, Bettina, additional, Schmeissner, Iris, additional, Jecel, Julia, additional, Tinchon, Alexander, additional, Storch, Maria K., additional, Reindl, Markus, additional, Berger, Thomas, additional, and Kristoferitsch, Wolfgang, additional

Published
2013
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9. Patterns of Antibody Binding to Aquaporin-4 Isoforms in Neuromyelitis Optica

Author

Mader, Simone, primary, Lutterotti, Andreas, additional, Di Pauli, Franziska, additional, Kuenz, Bettina, additional, Schanda, Kathrin, additional, Aboul-Enein, Fahmy, additional, Khalil, Michael, additional, Storch, Maria K., additional, Jarius, Sven, additional, Kristoferitsch, Wolfgang, additional, Berger, Thomas, additional, and Reindl, Markus, additional

Published
2010
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11. Endothelial Progenitor Cells, Cardiovascular Risk Factors, Cytokine Levels and Atherosclerosis – Results from a Large Population-Based Study

Author

Xiao, Qingzhong, primary, Kiechl, Stefan, additional, Patel, Seema, additional, Oberhollenzer, Friedrich, additional, Weger, Siegfried, additional, Mayr, Agnes, additional, Metzler, Bernhard, additional, Reindl, Markus, additional, Hu, Yanhua, additional, Willeit, Johann, additional, and Xu, Qingbo, additional

Published
2007
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12. Meta-Analysis of the Relationship between Multiple Sclerosis and Migraine.

Author

Pakpoor, Julia, Handel, Adam E., Giovannoni, Gavin, Dobson, Ruth, Ramagopalan, Sreeram V., and Reindl, Markus

Subjects
MULTIPLE sclerosis research, MIGRAINE, META-analysis, DISEASE prevalence, RANDOM effects model, SENSITIVITY analysis
Abstract

Background: Studies investigating a proposed association between multiple sclerosis (MS) and migraine have produced conflicting results and a great range in the prevalence rate of migraine in MS patients. By meta-analysing all available data we aimed to establish an overall estimate of any association in order to more accurately inform clinicians and care-givers about a potential association between MS and migraine. Methods: Pubmed and EMBASE were searched to identify suitable studies. Studies were included if they were a case-control study or cohort study in which controls were not reported to have another neurological condition, were available in English, and specified migraine as a headache sub-type. The odds ratio (OR) of migraine in MS patients vs. controls was calculated using the inverse variance with random effects model in Review Manager 5.1. Results: Eight studies were selected for inclusion, yielding a total of 1864 MS patients and 261563 control subjects. We found a significant association between migraine and MS (OR = 2.60, 95% CI 1.12-6.04), although there was significant heterogeneity. Sensitivity analysis showed that migraine without aura was associated with MS OR = 2.29 (95% CI 1.14-4.58), with no significant heterogeneity. Conclusions: MS patients are more than twice as likely to report migraine as controls. Care providers should be alerted to ask MS patients about migraine in order to treat it and potentially improve quality of life. Future work should further investigate the temporal relationship of this association and relationship to the clinical characteristics of MS. [ABSTRACT FROM AUTHOR]

Published
2012
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13. Association between Change in Normal Appearing White Matter Metabolites and Intrathecal Inflammation in Natalizumab-Treated Multiple Sclerosis.

Author

Mellergård, Johan, Tisell, Anders, Leinhard, Olof Dahlqvist, Blystad, Ida, Landtblom, Anne-Marie, Blennow, Kaj, Olsson, Bob, Dahle, Charlotte, Ernerudh, Jan, Lundberg, Peter, Vrethem, Magnus, and Reindl, Markus

Subjects
METABOLITES, BIOMOLECULES, BIOLOGICAL products, CENTRAL nervous system, NATALIZUMAB, MULTIPLE sclerosis research
Abstract

Background: Multiple sclerosis (MS) is associated not only with focal inflammatory lesions but also diffuse pathology in the central nervous system (CNS). Since there is no firm association between the amount of focal inflammatory lesions and disease severity, diffuse pathology in normal appearing white matter (NAWM) may be crucial for disease progression. Immunomodulating treatments for MS reduce the number of focal lesions, but possible effects on diffuse white matter pathology are less studied. Furthermore, it is not known whether intrathecal levels of inflammatory or neurodegenerative markers are associated with development of pathology in NAWM. Methods: Quantitative proton magnetic resonance spectroscopy (¹H-MRS) was used to investigate NAWM in 27 patients with relapsing MS before and after one year of treatment with natalizumab as well as NAWM in 20 healthy controls at baseline. Changes in ¹H-MRS metabolite concentrations during treatment were also correlated with a panel of intrathecal markers of inflammation and neurodegeneration in 24 of these 27 patients. Results: The group levels of ¹H-MRS metabolite concentrations were unchanged pre-to posttreatment, but a pattern of high magnitude correlation coefficients (r = 0.43-0.67, p,0.0005-0.03) were found between changes in individual metabolite concentrations (total creatine and total choline) and levels of pro-inflammatory markers (IL-1β and CXCL8). Conclusions: Despite a clinical improvement and a global decrease in levels of inflammatory markers in cerebrospinal fluid during treatment, high levels of pro-nflammatory CXCL8 and IL-1β were associated with an increase in H-MRS metabolites indicative of continued gliosis development and membrane turnover in NAWM. [ABSTRACT FROM AUTHOR]

Published
2012
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