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2 results on '"Rien van Haperen"'

1. Elevated expression of phospholipid transfer protein in bone marrow derived cells causes atherosclerosis.

Author

Rien van Haperen, Hannelore Samyn, Matthijs Moerland, Teus van Gent, Marian Peeters, Frank Grosveld, Arie van Tol, and Rini de Crom

Subjects
Medicine, Science
Abstract

BACKGROUND: Phospholipid transfer protein (PLTP) is expressed by various cell types. In plasma, it is associated with high density lipoproteins (HDL). Elevated levels of PLTP in transgenic mice result in decreased HDL and increased atherosclerosis. PLTP is present in human atherosclerotic lesions, where it seems to be macrophage derived. The aim of the present study is to evaluate the atherogenic potential of macrophage derived PLTP. METHODS AND FINDINGS: Here we show that macrophages from human PLTP transgenic mice secrete active PLTP. Subsequently, we performed bone marrow transplantations using either wild type mice (PLTPwt/wt), hemizygous PLTP transgenic mice (huPLTPtg/wt) or homozygous PLTP transgenic mice (huPLTPtg/tg) as donors and low density lipoprotein receptor deficient mice (LDLR-/-) as acceptors, in order to establish the role of PLTP expressed by bone marrow derived cells in diet-induced atherogenesis. Atherosclerosis was increased in the huPLTPtg/wt-->LDLR-/- mice (2.3-fold) and even further in the huPLTPtg/tg-->LDLR-/- mice (4.5-fold) compared with the control PLTPwt/wt-->LDLR-/- mice (both P

Published
2008
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2. Elevated expression of phospholipid transfer protein in bone marrow derived cells causes atherosclerosis

Author

Rini de Crom, Rien van Haperen, Marian Peeters, Teus van Gent, Matthijs Moerland, Arie van Tol, Hannelore Samyn, Frank Grosveld, and Cell biology

Subjects
Genetically modified mouse, medicine.medical_specialty, medicine.medical_treatment, Transgene, Cardiovascular Disorders, Cardiovascular Disorders/Coronary Artery Disease, lcsh:Medicine, Bone Marrow Cells, Mice, Transgenic, Biology, Biochemistry, chemistry.chemical_compound, Mice, Phospholipid transfer protein, Internal medicine, Blood plasma, medicine, Animals, Phospholipid Transfer Proteins, lcsh:Science, Bone Marrow Transplantation, Multidisciplinary, Cholesterol, Macrophages, lcsh:R, Atherosclerosis, Mice, Inbred C57BL, Endocrinology, Cytokine, medicine.anatomical_structure, chemistry, Receptors, LDL, Immunology, LDL receptor, lipids (amino acids, peptides, and proteins), lcsh:Q, Bone marrow, Research Article
Abstract

BACKGROUND: Phospholipid transfer protein (PLTP) is expressed by various cell types. In plasma, it is associated with high density lipoproteins (HDL). Elevated levels of PLTP in transgenic mice result in decreased HDL and increased atherosclerosis. PLTP is present in human atherosclerotic lesions, where it seems to be macrophage derived. The aim of the present study is to evaluate the atherogenic potential of macrophage derived PLTP. METHODS AND FINDINGS: Here we show that macrophages from human PLTP transgenic mice secrete active PLTP. Subsequently, we performed bone marrow transplantations using either wild type mice (PLTPwt/wt), hemizygous PLTP transgenic mice (huPLTPtg/wt) or homozygous PLTP transgenic mice (huPLTPtg/tg) as donors and low density lipoprotein receptor deficient mice (LDLR-/-) as acceptors, in order to establish the role of PLTP expressed by bone marrow derived cells in diet-induced atherogenesis. Atherosclerosis was increased in the huPLTPtg/wt-->LDLR-/- mice (2.3-fold) and even further in the huPLTPtg/tg-->LDLR-/- mice (4.5-fold) compared with the control PLTPwt/wt-->LDLR-/- mice (both P

Published
2008

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