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2. Circulating Inflammatory Mediators as Potential Prognostic Markers of Human Colorectal Cancer.

Author

Giuseppe Di Caro, Michele Carvello, Samantha Pesce, Marco Erreni, Federica Marchesi, Jelena Todoric, Matteo Sacchi, Marco Montorsi, Paola Allavena, and Antonino Spinelli

Subjects
Medicine, Science
Abstract

Cytokines and chemokines in the tumor microenvironment drive metastatic development and their serum levels might mirror the ongoing inflammatory reaction at the tumor site. Novel highly sensitive tools are needed to identify colorectal cancer patients at high risk of recurrence that should be more closely monitored during post-surgical follow up. Here we study whether circulating inflammatory markers might be used to predict recurrence in CRC patients.Circulating levels of the inflammatory cytokines IL-1, IL-6, IL-10, TNFalpha, CCL2, CXCL8, VEGF and the acute phase protein Pentraxin-3 were measured by ELISA in preoperative serum samples prospectively collected from a cohort of sixty-nine patients undergoing surgical resection for stage 0-IV CRC and associated with post-operative disease recurrence.Cox multivariate analysis showed that combined high levels (≥ROC cut off-value) of CXCL8, VEGF and Pentraxin3 were associated with increased risk of disease recurrence [HR: 14.28; 95%CI: (3.13-65.1)] independently of TNM staging. Kaplan-Meier analysis showed that CXCL8, VEGF and Pentraxin3 levels were significantly associated with worse survival (P

Published
2016
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3. Circulating Inflammatory Mediators as Potential Prognostic Markers of Human Colorectal Cancer

Author

Federica Marchesi, Marco Erreni, Samantha Pesce, Giuseppe Di Caro, Marco Montorsi, Michele Carvello, Matteo Sacchi, Jelena Todoric, Antonino Spinelli, and Paola Allavena

Subjects
0301 basic medicine, Oncology, Male, Colorectal cancer, Physiology, lcsh:Medicine, Pathology and Laboratory Medicine, Biochemistry, 0302 clinical medicine, Surgical oncology, Recurrence, Immune Physiology, Medicine and Health Sciences, Medicine, Postoperative Period, Stage (cooking), lcsh:Science, Immune Response, Innate Immune System, Multidisciplinary, Acute-phase protein, Hematology, Prognosis, Body Fluids, Blood, 030220 oncology & carcinogenesis, Cytokines, Tumor necrosis factor alpha, Female, medicine.symptom, Anatomy, Inflammation Mediators, Colorectal Neoplasms, Research Article, medicine.medical_specialty, Inflammatory Diseases, Immunology, Inflammation, Surgical and Invasive Medical Procedures, Blood Plasma, Proinflammatory cytokine, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Internal medicine, Biomarkers, Tumor, Humans, Aged, Neoplasm Staging, Colorectal Cancer, Tumor microenvironment, business.industry, lcsh:R, Cancers and Neoplasms, Biology and Life Sciences, Proteins, Correction, Acute Phase Proteins, Molecular Development, medicine.disease, 030104 developmental biology, Immune System, lcsh:Q, business, Developmental Biology, Follow-Up Studies
Abstract

Background Cytokines and chemokines in the tumor microenvironment drive metastatic development and their serum levels might mirror the ongoing inflammatory reaction at the tumor site. Novel highly sensitive tools are needed to identify colorectal cancer patients at high risk of recurrence that should be more closely monitored during post-surgical follow up. Here we study whether circulating inflammatory markers might be used to predict recurrence in CRC patients. Methods Circulating levels of the inflammatory cytokines IL-1, IL-6, IL-10, TNFalpha, CCL2, CXCL8, VEGF and the acute phase protein Pentraxin-3 were measured by ELISA in preoperative serum samples prospectively collected from a cohort of sixty-nine patients undergoing surgical resection for stage 0–IV CRC and associated with post-operative disease recurrence. Results Cox multivariate analysis showed that combined high levels (≥ROC cut off-value) of CXCL8, VEGF and Pentraxin3 were associated with increased risk of disease recurrence [HR: 14.28; 95%CI: (3.13–65.1)] independently of TNM staging. Kaplan-Meier analysis showed that CXCL8, VEGF and Pentraxin3 levels were significantly associated with worse survival (P

Published
2015

4. Correction: Circulating Inflammatory Mediators as Potential Prognostic Markers of Human Colorectal Cancer

Author

Samantha Pesce, Giuseppe Di Caro, Federica Marchesi, Antonino Spinelli, Paola Allavena, Michele Carvello, Marco Erreni, Matteo Sacchi, Jelena Todoric, and Marco Montorsi

Subjects
Oncology, medicine.medical_specialty, Pathology, Multidisciplinary, Colorectal cancer, business.industry, lcsh:R, lcsh:Medicine, medicine.disease, Marie curie, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, media_common.cataloged_instance, lcsh:Q, European union, lcsh:Science, business, 030215 immunology, media_common
Abstract

There is an error in the Funding section. The first sentence should read: The work was supported by 16230 Associazione Italiana per la ricerca sul cancro, Marie Curie Actions European Union to GDC.

Published
2016

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