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Your search keyword '"Sousa, A. R."' showing total 13 results
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13 results on '"Sousa, A. R."'

3. Intestinal anti-inflammatory effects of goat whey on DNBS-induced colitis in mice

Author

Araújo, Daline F. S., primary, Guerra, Gerlane C. B., additional, Pintado, Maria Manuela E., additional, Sousa, Yasmim R. F., additional, Algieri, Francesca, additional, Rodriguez-Nogales, Alba, additional, Araújo, Raimundo F., additional, Gálvez, Julio, additional, Queiroga, Rita de Cássia R. E., additional, and Rodriguez-Cabezas, Maria Elena, additional

Published
2017
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4. Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

Author

Sousa, Silmara R., primary, Wingerd, Joshua S., additional, Brust, Andreas, additional, Bladen, Christopher, additional, Ragnarsson, Lotten, additional, Herzig, Volker, additional, Deuis, Jennifer R., additional, Dutertre, Sebastien, additional, Vetter, Irina, additional, Zamponi, Gerald W., additional, King, Glenn F., additional, Alewood, Paul F., additional, and Lewis, Richard J., additional

Published
2017
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6. The role of interleukin 17-mediated immune response in Chagas disease: High level is correlated with better left ventricular function

Author

Sousa, Giovane R., primary, Gomes, Juliana A. S., additional, Damasio, Marcos Paulo S., additional, Nunes, Maria Carmo P., additional, Costa, Henrique S., additional, Medeiros, Nayara I., additional, Fares, Rafaelle C. G., additional, Chaves, Ana Thereza, additional, Corrêa-Oliveira, Rodrigo, additional, and Rocha, Manoel Otávio C., additional

Published
2017
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8. Correction: The WHO Maternal Near-Miss Approach and the Maternal Severity Index Model (MSI): Tools for Assessing the Management of Severe Maternal Morbidity

Author

Souza, Joao Paulo, primary, Cecatti, Jose Guilherme, additional, Haddad, Samira M., additional, Parpinelli, Mary Angela, additional, Costa, Maria Laura, additional, Katz, Leila, additional, Say, Lale, additional, Almeida, Elson J, additional, Amaral, Eliana M, additional, Amorim, Melania M, additional, Andreucci, Carla B, additional, Aquino, Márcia M, additional, Bahamondes, Maria V, additional, Lima, Antonio C Barbosa, additional, Barroso, Frederico, additional, Bione, Adriana, additional, Brum, Ione R, additional, Calderon, Iracema M, additional, Camargo, Rodrigo S, additional, Campanharo, Felipe F, additional, Carvalho, Luiz E, additional, Carvalho, Simone A, additional, Cecatti, José G, additional, Chaves, George N, additional, Cordioli, Eduardo, additional, Costa, Maria L, additional, Costa, Roberto A, additional, Costa, Sergio M, additional, Feitosa, Francisco E, additional, Freire, Djacyr M, additional, Gonçalves, Simone P, additional, Guanabara, Everardo M, additional, Guimarães, Daniela, additional, Gurgel, Lúcio T, additional, Haddad, Samira M, additional, Leite, Debora, additional, Lima, Moises D, additional, Lobato, Gustavo, additional, Lotufo, Fátima A, additional, Luz, Adriana G, additional, Filho, Nelson L Maia, additional, Martins, Marilia G, additional, Matias, Jacinta P, additional, Mattar, Rosiane, additional, Menezes, Carlos A, additional, Moises, Elaine C, additional, Filho, Olímpio B Moraes, additional, Moreira, Joaquim L, additional, Nakamura-Pereira, Marcos, additional, Nascimento, Denis J, additional, Ohnuma, Maria H, additional, Oliveira, Fernando C, additional, Pacagnella, Rodolfo C, additional, Paiva, Cláudio S, additional, Parpinelli, Mary A, additional, Pattinson, Robert C, additional, Paula, Liv B, additional, Peraçoli, Jose C, additional, Peret, Frederico A, additional, Perez, Cynthia D, additional, Pessoni, Cleire, additional, Peterossi, Alessandra, additional, Pfitscher, Lucia C, additional, Silva, João L Pinto e, additional, Quintana, Silvana M, additional, Radaci, Ivelyne, additional, Filho, Edilberto A Rocha, additional, Rodrigues, Simone M, additional, Rohloff, Roger D, additional, Rudge, Marilza V, additional, Saint'ynes, Gloria C, additional, Santana, Danielly S, additional, Santos, Patricia N, additional, Schmaltz, Luiza E, additional, Sousa, Maria H, additional, Sousa, Maria R, additional, Souza, Joäo P, additional, Surita, Fernanda G, additional, Zanette, Elvira A, additional, and Zotareli, Vilma, additional

Published
2013
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10. Violacein Induces Death of Resistant Leukaemia Cells via Kinome Reprogramming, Endoplasmic Reticulum Stress and Golgi Apparatus Collapse

Author

Queiroz, Karla C. S., primary, Milani, Renato, additional, Ruela-de-Sousa, Roberta R., additional, Fuhler, Gwenny M., additional, Justo, Giselle Z., additional, Zambuzzi, Willian F., additional, Duran, Nelson, additional, Diks, Sander H., additional, Spek, C. Arnold, additional, Ferreira, Carmen V., additional, and Peppelenbosch, Maikel P., additional

Published
2012
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11. Knocking Down Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP) Reverts Chemoresistance through Inactivation of Src and Bcr-Abl Proteins

Author

Ferreira, Paula A., primary, Ruela-de-Sousa, Roberta R., additional, Queiroz, Karla C. S., additional, Souza, Ana Carolina S., additional, Milani, Renato, additional, Pilli, Ronaldo Aloise, additional, Peppelenbosch, Maikel P., additional, Hertog, Jeroen den, additional, and Ferreira, Carmen V., additional

Published
2012
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13. Expression and Pharmacology of Endogenous Cav Channels in SH-SY5Y Human Neuroblastoma Cells.

Author

Sousa, Silmara R., Vetter, Irina, Ragnarsson, Lotten, and Lewis, Richard J.

Subjects
*NEUROBLASTOMA, *GENE expression, *PHARMACOLOGY, *CALCIUM channels, *CANCER cells, *CELL physiology, *MESSENGER RNA, *CELLULAR signal transduction, *THERAPEUTICS
Abstract

SH-SY5Y human neuroblastoma cells provide a useful in vitro model to study the mechanisms underlying neurotransmission and nociception. These cells are derived from human sympathetic neuronal tissue and thus, express a number of the Cav channel subtypes essential for regulation of important physiological functions, such as heart contraction and nociception, including the clinically validated pain target Cav2.2. We have detected mRNA transcripts for a range of endogenous expressed subtypes Cav1.3, Cav2.2 (including two Cav1.3, and three Cav2.2 splice variant isoforms) and Cav3.1 in SH-SY5Y cells; as well as Cav auxiliary subunits α2δ1–3, β1, β3, β4, γ1, γ4–5, and γ7. Both high- and low-voltage activated Cav channels generated calcium signals in SH-SY5Y cells. Pharmacological characterisation using ω-conotoxins CVID and MVIIA revealed significantly (∼ 10-fold) higher affinity at human versus rat Cav2.2, while GVIA, which interacts with Cav2.2 through a distinct pharmacophore had similar affinity for both species. CVID, GVIA and MVIIA affinity was higher for SH-SY5Y membranes vs whole cells in the binding assays and functional assays, suggesting auxiliary subunits expressed endogenously in native systems can strongly influence Cav2.2 channels pharmacology. These results may have implications for strategies used to identify therapeutic leads at Cav2.2 channels. [ABSTRACT FROM AUTHOR]

Published
2013
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