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1. Clinical efficacy and safety of mesenchymal stem cell transplantation for osteoarthritis treatment: A meta-analysis.

Author

Ma Yubo, Li Yanyan, Li Li, Sun Tao, Lin Bo, and Chen Lin

Subjects
Medicine, Science
Abstract

PURPOSE:The aim of this study was to evaluate the therapeutic efficacy and safety of mesenchymal stem cells (MSCs) for the treatment of patients with knee osteoarthritis (OA). MATERIALS:We performed a meta-analysis of relevant published clinical studies. An electronic search was conducted for randomized controlled trials (RCTs) of MSC-based therapy in knee OA. The visual analogue scale (VAS), International Knee Documentation Committee (IKDC) form, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Lequesne algofunctional indices (Lequesne), Lysholm knee scale (Lysholm), Tegner activity scale (Tegner) and adverse events (AEs) were evaluated. RESULTS:Eleven eligible trials with 582 knee OA patients were included in the present meta-analysis. We demonstrated that MSC treatment could significantly decrease VAS and increase IKDC scoresafter a 24-month follow-up compared with controls (P

Published
2017
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10. Clinical efficacy and safety of mesenchymal stem cell transplantation for osteoarthritis treatment: A meta-analysis

Author

Chen Lin, Ma Yubo, Li Li, Li Yanyan, Sun Tao, and Lin Bo

Subjects
0301 basic medicine, Knees, lcsh:Medicine, Osteoarthritis, Knee Joints, law.invention, 0302 clinical medicine, Mathematical and Statistical Techniques, Randomized controlled trial, law, Animal Cells, Medicine and Health Sciences, lcsh:Science, Musculoskeletal System, Connective Tissue Cells, 030222 orthopedics, Multidisciplinary, Stem Cells, Stem Cell Therapy, Osteoarthritis, Knee, Connective Tissue, Meta-analysis, Physical Sciences, Legs, Safety, Cellular Types, Anatomy, Statistics (Mathematics), Research Article, medicine.medical_specialty, WOMAC, Visual analogue scale, Mesenchymal Stem Cell Transplantation, Research and Analysis Methods, 03 medical and health sciences, Chondrocytes, Rheumatology, Internal medicine, medicine, Humans, Statistical Methods, Adverse effect, Clinical Genetics, business.industry, Arthritis, lcsh:R, Limbs (Anatomy), Biology and Life Sciences, Mesenchymal Stem Cells, Cell Biology, medicine.disease, Transplantation, Joints (Anatomy), 030104 developmental biology, Biological Tissue, Cartilage, lcsh:Q, business, Tegner Activity Scale, Mathematics, Meta-Analysis
Abstract

Purpose The aim of this study was to evaluate the therapeutic efficacy and safety of mesenchymal stem cells (MSCs) for the treatment of patients with knee osteoarthritis (OA). Materials We performed a meta-analysis of relevant published clinical studies. An electronic search was conducted for randomized controlled trials (RCTs) of MSC-based therapy in knee OA. The visual analogue scale (VAS), International Knee Documentation Committee (IKDC) form, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Lequesne algofunctional indices (Lequesne), Lysholm knee scale (Lysholm), Tegner activity scale (Tegner) and adverse events (AEs) were evaluated. Results Eleven eligible trials with 582 knee OA patients were included in the present meta-analysis. We demonstrated that MSC treatment could significantly decrease VAS and increase IKDC scoresafter a 24-month follow-up compared with controls (P

Published
2016

17. Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish

Author

Zhang, Meiling, primary, Sun, Tao, additional, Jian, Chongshu, additional, Lei, Lei, additional, Han, Peidong, additional, Lv, Quanlong, additional, Yang, Ran, additional, Zhou, Xiaohai, additional, Xu, Jiejia, additional, Hu, Yingchun, additional, Men, Yongfan, additional, Huang, Yanyi, additional, Zhang, Chuanmao, additional, Zhu, Xiaojun, additional, Wang, Xianhua, additional, Cheng, Heping, additional, and Xiong, Jing-Wei, additional

Published
2015
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24. Contourlet Textual Features: Improving the Diagnosis of Solitary Pulmonary Nodules in Two Dimensional CT Images

Author

Wang, Jingjing, primary, Sun, Tao, additional, Gao, Ni, additional, Menon, Desmond Dev, additional, Luo, Yanxia, additional, Gao, Qi, additional, Li, Xia, additional, Wang, Wei, additional, Zhu, Huiping, additional, Lv, Pingxin, additional, Liang, Zhigang, additional, Tao, Lixin, additional, Liu, Xiangtong, additional, and Guo, Xiuhua, additional

Published
2014
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30. Maternal Mortality in Henan Province, China: Changes between 1996 and 2009

Author

You, Fengzhi, primary, Huo, Kaiming, additional, Wang, Ruili, additional, Xu, Dongmei, additional, Deng, Jie, additional, Wei, Ying, additional, Shi, Fenglian, additional, Liu, Hongyang, additional, Cheng, Guomei, additional, Zhang, Zhan, additional, Yang, Ping, additional, Sun, Tao, additional, Wang, Xiaoyang, additional, Jacobsson, Bo, additional, and Zhu, Changlian, additional

Published
2012
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37. Lycium barbarum Polysaccharide Prevents Focal Cerebral Ischemic Injury by Inhibiting Neuronal Apoptosis in Mice.

Author

Wang, Tengfei, Li, Yuxiang, Wang, Yongsheng, Zhou, Ru, Ma, Lin, Hao, Yinju, Jin, Shaoju, Du, Juan, Zhao, Chengjun, Sun, Tao, and Yu, Jianqiang

Subjects
CEREBRAL ischemia, APOPTOSIS inhibition, NEUROPROTECTIVE agents, CEREBRAL arterial diseases, ARTERIAL occlusions, POLYSACCHARIDES, SOLANACEAE, PREVENTION, THERAPEUTICS
Abstract

Aims of the Study: To investigate the neuroprotective effect of Lycium barbarum polysaccharide (LBP) on focal cerebral ischemic injury in mice and to explore its possible mechanism. Materials and Methods: Male ICR mice were used to make the model of middle cerebral artery occlusion (MCAO) after intragastric administration with LBP (10, 20 and 40 mg/kg) and Nimodipine (0.4 mg/kg) for seven successive days. After 24 h of reperfusion, neurological scores were estimated and infarct volumes were measured by 2, 3, 5-triphenyltetrazolium chloride (TTC) staining. Morphological changes in ischemic brains were performed for hematoxylin-eosin (HE) staining. The number of apoptotic neurons was detected by TUNEL staining. The Bax, Bcl-2 protein expression and CytC, Caspase-3, -9 and cleaved PARP-1 activation were investigated by immunofluorescence and western-blot analysis. Results: LBP (10, 20 and 40 mg/kg) treatment groups significantly reduced infract volume and neurological deficit scores. LBP also relieved neuronal morphological damage and attenuated the neuronal apoptosis. LBP at the dose of 40 mg/kg significantly suppressed overexpression of Bax, CytC, Caspase-3, -9 and cleaved PARP-1, and inhibited the reduction of Bcl-2 expression. Conclusions: Based on these findings we propose that LBP protects against focal cerebral ischemic injury by attenuating the mitochondrial apoptosis pathway. [ABSTRACT FROM AUTHOR]

Published
2014
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38. Exploring hypotheses of the actions of TGF-beta1 in epidermal wound healing using a 3D computational multiscale model of the human epidermis.

Author

Sun T, Adra S, Smallwood R, Holcombe M, and MacNeil S

Subjects
Basement Membrane metabolism, Cell Differentiation, Cell Movement, Cell Proliferation, Homeostasis, Humans, Subcellular Fractions metabolism, Computer Simulation, Epidermis metabolism, Epidermis pathology, Models, Biological, Transforming Growth Factor beta1 metabolism, Wound Healing
Abstract

In vivo and in vitro studies give a paradoxical picture of the actions of the key regulatory factor TGF-beta1 in epidermal wound healing with it stimulating migration of keratinocytes but also inhibiting their proliferation. To try to reconcile these into an easily visualized 3D model of wound healing amenable for experimentation by cell biologists, a multiscale model of the formation of a 3D skin epithelium was established with TGF-beta1 literature-derived rule sets and equations embedded within it. At the cellular level, an agent-based bottom-up model that focuses on individual interacting units (keratinocytes) was used. This was based on literature-derived rules governing keratinocyte behavior and keratinocyte/ECM interactions. The selection of these rule sets is described in detail in this paper. The agent-based model was then linked with a subcellular model of TGF-beta1 production and its action on keratinocytes simulated with a complex pathway simulator. This multiscale model can be run at a cellular level only or at a combined cellular/subcellular level. It was then initially challenged (by wounding) to investigate the behavior of keratinocytes in wound healing at the cellular level. To investigate the possible actions of TGF-beta1, several hypotheses were then explored by deliberately manipulating some of these rule sets at subcellular levels. This exercise readily eliminated some hypotheses and identified a sequence of spatial-temporal actions of TGF-beta1 for normal successful wound healing in an easy-to-follow 3D model. We suggest this multiscale model offers a valuable, easy-to-visualize aid to our understanding of the actions of this key regulator in wound healing, and provides a model that can now be used to explore pathologies of wound healing.

Published
2009
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