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Your search keyword '"Takahashi, Masaki"' showing total 9 results
Start Over Author "Takahashi, Masaki" Journal plos one
9 results on '"Takahashi, Masaki"'

1. Detailed analysis of the transverse arch of hallux valgus feet with and without pain using weightbearing ultrasound imaging and precise force sensors

Author

Zeidan, Hala, primary, Ryo, Eguchi, additional, Suzuki, Yusuke, additional, Iijima, Hirotaka, additional, Kajiwara, Yuu, additional, Harada, Keiko, additional, Nakai, Kengo, additional, Shimoura, Kanako, additional, Fujimoto, Koji, additional, Takahashi, Masaki, additional, and Aoyama, Tomoki, additional

Published
2020
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9. Specific Inhibition of Tumor Cells by Oncogenic EGFR Specific Silencing by RNA interference.

Author

Takahashi, Masaki, Chiyo, Tomoko, Okada, Takashi, and Hohjoh, Hirohiko

Subjects
*ONCOGENES, *EPIDERMAL growth factor receptors, *GENE silencing, *RNA interference, *ANTINEOPLASTIC agents, *GENETIC mutation, *ALLELES
Abstract

Anticancer agents that have minimal effects on normal cells and tissues are ideal cancer drugs. Here, we show specific inhibition of human cancer cells carrying oncogenic mutations in the epidermal growth factor receptor (EGFR) gene by means of oncogenic allele-specific RNA interference (RNAi), both in vivo and in vitro. The allele-specific RNAi (ASP-RNAi) treatment did not affect normal cells or tissues that had no target oncogenic allele, whereas the suppression of a normal EGFR allele by a conventional in vivo RNAi caused adverse effects, i.e., normal EGFR is vital. Taken together, our current findings suggest that specific inhibition of oncogenic EGFR alleles without affecting the normal EGFR allele may provide a safe treatment approach for cancer patients and that ASP-RNAi treatment may be capable of becoming a safe and effective, anticancer treatment method. [ABSTRACT FROM AUTHOR]

Published
2013
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