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1. Loss of Pol32 in Drosophila melanogaster causes chromosome instability and suppresses variegation.

Author

Patrizia Tritto, Valeria Palumbo, Lucia Micale, Marco Marzulli, Maria Pia Bozzetti, Valeria Specchia, Gioacchino Palumbo, Sergio Pimpinelli, and Maria Berloco

Subjects
Medicine, Science
Abstract

Pol32 is an accessory subunit of the replicative DNA Polymerase δ and of the translesion Polymerase ζ. Pol32 is involved in DNA replication, recombination and repair. Pol32's participation in high- and low-fidelity processes, together with the phenotypes arising from its disruption, imply multiple roles for this subunit within eukaryotic cells, not all of which have been fully elucidated. Using pol32 null mutants and two partial loss-of-function alleles pol32rd1 and pol32rds in Drosophila melanogaster, we show that Pol32 plays an essential role in promoting genome stability. Pol32 is essential to ensure DNA replication in early embryogenesis and it participates in the repair of mitotic chromosome breakage. In addition we found that pol32 mutants suppress position effect variegation, suggesting a role for Pol32 in chromatin architecture.

Published
2015
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2. Loss of Pol32 in Drosophila melanogaster causes chromosome instability and suppresses variegation

Author

Valeria Specchia, Sergio Pimpinelli, G. Palumbo, Marco Marzulli, Valeria Palumbo, Lucia Micale, Patrizia Tritto, Maria Pia Bozzetti, Maria Berloco, Tritto, Patrizia, Palumbo, Valeria, Micale, Lucia, Marzulli, Marco, Bozzetti, Maria Giuseppina, Specchia, Valeria, Palumbo, Gioacchino, Pimpinelli, Sergio, and Berloco, Maria

Subjects
Genetics, Multidisciplinary, biology, DNA repair, DNA polymerase, Science, DNA replication, DNA-Directed DNA Polymerase, Position-effect variegation, DNA polymerase delta, Chromatin, Proliferating cell nuclear antigen, Drosophila melanogaster, Position effect, Chromosomal Instability, biology.protein, Drosophila Proteins, Animals, Medicine, Female, Alleles, Research Article
Abstract

Pol32 is an accessory subunit of the replicative DNA Polymerase delta and of the translesion Polymerase zeta. Pol32 is involved in DNA replication, recombination and repair. Pol32's participation in high-and low-fidelity processes, together with the phenotypes arising from its disruption, imply multiple roles for this subunit within eukaryotic cells, not all of which have been fully elucidated. Using pol32 null mutants and two partial loss-of-function alleles pol32(rd1) and pol32(rds) in Drosophila melanogaster, we show that Pol32 plays an essential role in promoting genome stability. Pol32 is essential to ensure DNA replication in early embryogenesis and it participates in the repair of mitotic chromosome breakage. In addition we found that pol32 mutantssuppress position effect variegation, suggesting a role for Pol32 in chromatin architecture.

Published
2015

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