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8 results on '"Wang, Lizhen"'

5. Development of a Novel PET Tracer [18F]AlF-NOTA-C6 Targeting MMP2 for Tumor Imaging.

Author

Liu, Qinghua, Pan, Donghui, Cheng, Chao, Zhang, Dazhi, Zhang, Anyu, Wang, Lizhen, Jiang, Hongdie, Wang, Tao, Liu, Hongrui, Xu, Yuping, Yang, Runlin, Chen, Fei, Yang, Min, and Zuo, Changjing

Subjects
MATRIX metalloproteinases, CANCER invasiveness, GELATINASES, GENETIC overexpression, IMAGING of cancer, POSITRON emission tomography
Abstract

Background and Objective: The overexpression of gelatinases, that is, matrix metalloproteinase MMP2 and MMP9, has been associated with tumor progression, invasion, and metastasis. To image MMP2 in tumors, we developed a novel ligand termed [18F]AlF-NOTA-C6, with consideration that: c(KAHWGFTLD)NH2 (herein, C6) is a selective gelatinase inhibitor; Cy5.5-C6 has been visualized in many in vivo tumor models; positron emission tomography (PET) has a higher detection sensitivity and a wider field of view than optical imaging; fluorine-18 (18F) is the optimal PET radioisotope, and the creation of a [18F]AlF-peptide complex is a simple procedure. Methods: C6 was conjugated to the bifunctional chelator NOTA (1, 4, 7-triazacyclononanetriacetic acid) for radiolabeling [18F]AlF conjugation. The MMP2-binding characteristics and tumor-targeting efficacy of [18F]AlF-NOTA-C6 were tested in vitro and in vivo. Results: The non-decay corrected yield of [18F]AlF-NOTA-C6 was 46.2–64.2%, and the radiochemical purity exceeded 95%. [18F]AlF-NOTA-C6 was favorably retained in SKOV3 and PC3 cells, determined by cell uptake. Using NOTA-C6 as a competitive ligand, the uptake of [18F]AlF-NOTA-C6 in SKOV3 cells decreased in a dose-dependent manner. In biodistribution and PET imaging studies, higher radioactivity concentrations were observed in tumors. Pre-injection of C6 caused a marked reduction in tumor tissue uptake. Immunohistochemistry showed MMP2 in tumor tissues. Conclusions: [18F]AlF-NOTA-C6 was easy to synthesize and has substantial potential as an imaging agent that targets MMP2 in tumors. [ABSTRACT FROM AUTHOR]

Published
2015
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6. CCND1 as a Predictive Biomarker of Neoadjuvant Chemotherapy in Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma

Author

Feng, Zhien, primary, Guo, Wei, additional, Zhang, Chenping, additional, Xu, Qin, additional, Zhang, Ping, additional, Sun, Jian, additional, Zhu, Hanguang, additional, Wang, Zhonghe, additional, Li, Jiang, additional, Wang, Lizhen, additional, Wang, Bingshun, additional, Ren, Guoxin, additional, Ji, Tong, additional, Tu, Wenyong, additional, Yang, Xihu, additional, Qiu, Weiliu, additional, Mao, Li, additional, Zhang, Zhiyuan, additional, and Chen, Wantao, additional

Published
2011
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8. Tumor-Initiating Cells Are Enriched in CD44hi Population in Murine Salivary Gland Tumor

Author

Shen, Shukun, primary, Yang, Wenjun, additional, Wang, Zhugang, additional, Lei, Xia, additional, Xu, Liqun, additional, Wang, Yang, additional, Wang, Lizhen, additional, Huang, Lei, additional, Yu, Zhiwei, additional, Zhang, Xinhong, additional, Li, Jiang, additional, Chen, Yan, additional, Zhao, Xiaoping, additional, Yin, Xuelai, additional, and Zhang, Chenping, additional

Published
2011
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