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In this article, we study the applicability of Benford's law and Zipf's law to national COVID-19 case figures with the aim of establishing guidelines upon which methods of fraud detection in epidemiology, based on formal statistical analysis, can be developed. Moreover, these approaches may also be used in evaluating the performance of public health surveillance systems. We provide theoretical arguments for why the empirical laws should hold in the early stages of an epidemic, along with preliminary empirical evidence in support of these claims. Based on data published by the World Health Organization and various national governments, we find empirical evidence that suggests that both Benford's law and Zipf's law largely hold across countries, and deviations can be readily explained. To the best of our knowledge, this paper is among the first to present a practical application of Zipf's law to fraud detection. [ABSTRACT FROM AUTHOR]

In this paper, we propose a portmanteau test for whether a graph-structured network dataset without replicates exhibits autocorrelation across units connected by edges. Specifically, the well known Ljung-Box test for serial autocorrelation of time series data is generalized to the network setting using a specially derived central limit theorem for a weakly stationary random field. The asymptotic distribution of the test statistic under the null hypothesis of no autocorrelation is shown to be chi-squared, yielding a simple and easy-to-implement procedure for testing graph-structured autocorrelation, including spatial and spatial-temporal autocorrelation as special cases. Numerical simulations are carried out to demonstrate and confirm the derived asymptotic results. Convergence is found to occur quickly depending on the number of lags included in the test statistic, and a significant increase in statistical power is also observed relative to some recently proposed permutation tests. An example application is presented by fitting spatial autoregressive models to the distribution of COVID-19 cases across counties in New York state. [ABSTRACT FROM AUTHOR]