Search

Your search keyword '"Yazdanbakhsh, Maria"' showing total 25 results
Start Over Author "Yazdanbakhsh, Maria" Journal plos one
25 results on '"Yazdanbakhsh, Maria"'

1. Investigation of urinary metabolomics in a phase I hookworm vaccine trial in Gabon

Author

Betouke Ongwe, Madeleine Eunice, primary, Mouwenda, Yoanne D., additional, Stam, Koen A., additional, Kremsner, Peter G., additional, Lell, Bertrand, additional, Diemert, David, additional, Bethony, Jeff, additional, Bottazzi, Maria E., additional, Hotez, Peter J., additional, Leeuwen, Remko V., additional, Grobusch, Martin P., additional, Adegnika, Ayola A., additional, Mayboroda, Oleg A., additional, and Yazdanbakhsh, Maria, additional

Published
2022
Full Text
View/download PDF

2. Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children

Author

Alcantara-Neves, Neuza M., primary, Veiga, Rafael V., additional, Ponte, João C. M., additional, da Cunha, Sérgio S., additional, Simões, Silvia M., additional, Cruz, Álvaro A., additional, Yazdanbakhsh, Maria, additional, Matos, Sheila M., additional, Silva, Thiago Magalhães, additional, Figueiredo, Camila A., additional, Pontes-de-Carvalho, Lain C., additional, Rodrigues, Laura C., additional, Fiaccone, Rosemeire L., additional, Cooper, Philip J., additional, and Barreto, Maurício L., additional

Published
2017
Full Text
View/download PDF

3. CD4+CD25hiFOXP3+ cells in cord blood of neonates born from filaria infected mother are negatively associated with CD4+Tbet+ and CD4+RORγt+ T cells

Author

Ateba-Ngoa, Ulysse, Mombo-Ngoma, Ghyslain, Zettlmeissl, Eva, van der Vlugt, Luciën E. P. M., de Jong, Sanne, Matsiegui, Pierre-Blaise, Ramharter, Michael, Kremsner, Peter G., Yazdanbakhsh, Maria, and Adegnika, Ayola Akim

Subjects
Infectious Diseases, Immunology, lcsh:R, Medicine and Health Sciences, Parasitic Diseases, Biology and Life Sciences, lcsh:Medicine, Parasitology, lcsh:Q, Cell Biology, Tropical Diseases, lcsh:Science, Research Article
Abstract

Background Children who have been exposed in utero to maternal filarial infection are immunologically less responsive to filarial antigens, have less pathology, and are more susceptible to acquire infection than offspring of uninfected mothers. Moreover children from filaria infected mothers have been shown to be less responsive to vaccination as a consequence of an impairment of their immune response. However, it is not well known how in utero exposure to parasite antigens affects cellular immune responses. Methodology Here, 30 pregnant women were examined for the presence of microfilaria of Loa loa and Mansonella perstans in peripheral blood. At delivery, cord blood mononuclear cells (CBMC) were obtained and the CD4+T cells were phenotyped by expression of the transcription factors Tbet, RORγt, and FOXP3. Results No significant difference was observed between newborns from infected versus uninfected mothers in the frequencies of total CD4+T cells and CD4+T cells subsets including CD4+Tbet+, CD4+RORγt+ T and CD4+CD25hiFOXP3+ T cells. However, there was a negative association between CD4+CD25hiFOXP3+T cells and CD4+Tbet+ as well as CD4+RORγt+ T cells in the infected group only (B = −0.242, P = 0.002; B = −0.178, P = 0.013 respectively). Conclusion Our results suggest that filarial infection during pregnancy leads to an expansion of functionally active regulatory T cells that keep TH1 and TH17 in check.

Published
2014

4. Differences in innate cytokine responses between European and African children

Author

Labuda, Lucja A., de Jong, Sanne E., Meurs, Lynn, Amoah, Abena S., Mbow, Moustapha, Ateba-Ngoa, Ulysse, van der Ham, Alwin J., Knulst, André C., Yazdanbakhsh, Maria, and Adegnika, Ayola A.

Subjects
Male, Adolescent, Science, Immunology, Black People, Global Health, Research and Analysis Methods, White People, Medicine and Health Sciences, Humans, Public and Occupational Health, Gabon, Immunoassays, Child, Immune Response, Netherlands, Innate Immune System, Interleukin-6, Toll-Like Receptors, Immunity, Biology and Life Sciences, Molecular Development, Immunity, Innate, Interleukin-10, Immune System, Immunologic Techniques, Cytokines, Medicine, Clinical Immunology, Female, Research Article, Developmental Biology
Abstract

Although differences in immunological responses between populations have been found in terms of vaccine efficacy, immune responses to infections and prevalence of chronic inflammatory diseases, the mechanisms responsible for these differences are not well understood. Therefore, innate cytokine responses mediated by various classes of pattern-recognition receptors including Toll-like receptors (TLR), C-type lectin receptors (CLRs) and nucleotide-binding oligomerisation domain-like receptors (NLRs) were compared between Dutch (European), semi-urban and rural Gabonese (African) children. Whole blood was stimulated for 24 hours and the pro-inflammatory tumor necrosis factor (TNF) and the anti-inflammatory/regulatory interleukin-10 (IL-10) cytokines in culture supernatant were measured by enzyme-linked immunosorbent assay (ELISA). Gabonese children had a lower pro-inflammatory response to poly(I:C) (TLR3 ligand), but a higher pro-inflammatory response to FSL-1 (TLR2/6 ligand), Pam3 (TLR2/1 ligand) and LPS (TLR4 ligand) compared to Dutch children. Anti-inflammatory responses to Pam3 were also higher in Gabonese children. Non-TLR ligands did not induce substantial cytokine production on their own. Interaction between various TLR and non-TLR receptors was further assessed, but no differences were found between the three populations. In conclusion, using a field applicable assay, significant differences were observed in cytokine responses between European and African children to TLR ligands, but not to non-TLR ligands.

Published
2014

6. Correction: Infection with Soil-Transmitted Helminths Is Associated with Increased Insulin Sensitivity

Author

Wiria, Aprilianto E., primary, Hamid, Firdaus, additional, Wammes, Linda J., additional, Prasetyani, Margaretta A., additional, Dekkers, Olaf M., additional, May, Linda, additional, Kaisar, Maria M. M., additional, Verweij, Jaco J., additional, Guigas, Bruno, additional, Partono, Felix, additional, Sartono, Erliyani, additional, Supali, Taniawati, additional, Yazdanbakhsh, Maria, additional, and Smit, Johannes W. A., additional

Published
2015
Full Text
View/download PDF

7. Infection with Soil-Transmitted Helminths Is Associated with Increased Insulin Sensitivity

Author

Wiria, Aprilianto E., primary, Hamid, Firdaus, additional, Wammes, Linda J., additional, Prasetyani, Margaretta A., additional, Dekkers, Olaf M., additional, May, Linda, additional, Kaisar, Maria M. M., additional, Verweij, Jaco J., additional, Guigas, Bruno, additional, Partono, Felix, additional, Sartono, Erliyani, additional, Supali, Taniawati, additional, Yazdanbakhsh, Maria, additional, and Smit, Johannes W. A., additional

Published
2015
Full Text
View/download PDF

8. A Randomized Trial of an Early Measles Vaccine at 4½ Months of Age in Guinea-Bissau: Sex-Differential Immunological Effects

Author

Jensen, Kristoffer Jarlov, primary, Søndergaard, Mia, additional, Andersen, Andreas, additional, Sartono, Erliyani, additional, Martins, Cesario, additional, Garly, May-Lill, additional, Eugen-Olsen, Jesper, additional, Ullum, Henrik, additional, Yazdanbakhsh, Maria, additional, Aaby, Peter, additional, Benn, Christine Stabell, additional, and Erikstrup, Christian, additional

Published
2014
Full Text
View/download PDF

11. Correction: The Effect of Three-Monthly Albendazole Treatment on Malarial Parasitemia and Allergy: A Household-Based Cluster-Randomized, Double-Blind, Placebo-Controlled Trial

Author

Wiria, Aprilianto E., primary, Hamid, Firdaus, additional, Wammes, Linda J., additional, Kaisar, Maria M. M., additional, May, Linda, additional, Prasetyani, Margaretta A., additional, Wahyuni, Sitti, additional, Djuardi, Yenny, additional, Ariawan, Iwan, additional, Wibowo, Heri, additional, Lell, Bertrand, additional, Sauerwein, Robert, additional, Brice, Gary T., additional, Sutanto, Inge, additional, van Lieshout, Lisette, additional, de Craen, Anton J. M., additional, van Ree, Ronald, additional, Verweij, Jaco J., additional, Tsonaka, Roula, additional, Houwing-Duistermaat, Jeanine J., additional, Luty, Adrian J. F., additional, Sartono, Erliyani, additional, Supali, Taniawati, additional, and Yazdanbakhsh, Maria, additional

Published
2013
Full Text
View/download PDF

13. The Mucosal Adjuvant Cholera Toxin B Instructs Non-Mucosal Dendritic Cells to Promote IgA Production Via Retinoic Acid and TGF-β

Author

Gloudemans, Anouk K., primary, Plantinga, Maud, additional, Guilliams, Martin, additional, Willart, Monique A., additional, Ozir-Fazalalikhan, Arifa, additional, van der Ham, Alwin, additional, Boon, Louis, additional, Harris, Nicola L., additional, Hammad, Hamida, additional, Hoogsteden, Henk C., additional, Yazdanbakhsh, Maria, additional, Hendriks, Rudi W., additional, Lambrecht, Bart N., additional, and Smits, Hermelijn H., additional

Published
2013
Full Text
View/download PDF

14. The Effect of Three-Monthly Albendazole Treatment on Malarial Parasitemia and Allergy: A Household-Based Cluster-Randomized, Double-Blind, Placebo-Controlled Trial

Author

Wiria, Aprilianto E., primary, Hamid, Firdaus, additional, Wammes, Linda J., additional, Kaisar, Maria M. M., additional, May, Linda, additional, Prasetyani, Margaretta A., additional, Wahyuni, Sitti, additional, Djuardi, Yenny, additional, Ariawan, Iwan, additional, Wibowo, Heri, additional, Lell, Bertrand, additional, Sauerwein, Robert, additional, Brice, Gary T., additional, Sutanto, Inge, additional, van Lieshout, Lisette, additional, de Craen, Anton J. M., additional, van Ree, Ronald, additional, Verweij, Jaco J., additional, Tsonaka, Roula, additional, Houwing-Duistermaat, Jeanine J., additional, Luty, Adrian J. F., additional, Sartono, Erliyani, additional, Supali, Taniawati, additional, and Yazdanbakhsh, Maria, additional

Published
2013
Full Text
View/download PDF

15. Relationship between Carotid Intima Media Thickness and Helminth Infections on Flores Island, Indonesia

Author

Wiria, Aprilianto Eddy, primary, Wammes, Linda J., additional, Hamid, Firdaus, additional, Dekkers, Olaf M., additional, Prasetyani, Margaretta A., additional, May, Linda, additional, Kaisar, Maria M. M., additional, Verweij, Jaco J., additional, Tamsma, Jouke T., additional, Partono, Felix, additional, Sartono, Erliyani, additional, Supali, Taniawati, additional, Yazdanbakhsh, Maria, additional, and Smit, Johannes W. A., additional

Published
2013
Full Text
View/download PDF

16. Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4+ Th-Cells.

Author

Mouser, Emily E. I. M., Pollakis, Georgios, Yazdanbakhsh, Maria, Harnett, William, de Jong, Esther C., and Paxton, William A.

Subjects
HIV-positive persons, BRUGIA malayi, CD4 antigen, T helper cells, HIV infections -- Immunological aspects, VIRAL replication
Abstract

One of the hallmarks of HIV-1 disease is the association of heightened CD4+ T-cell activation with HIV-1 replication. Parasitic helminths including filarial nematodes have evolved numerous and complex mechanisms to skew, dampen and evade human immune responses suggesting that HIV-1 infection may be modulated in co-infected individuals. Here we studied the effects of two filarial nematode products, adult worm antigen from Brugia malayi (BmA) and excretory-secretory product 62 (ES-62) from Acanthocheilonema viteae on HIV-1 infection in vitro. Neither BmA nor ES-62 influenced HIV-1 replication in CD4+ enriched T-cells, with either a CCR5- or CXCR4-using virus. BmA, but not ES-62, had the capacity to bind the C-type lectin dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) thereby inhibiting HIV-1 trans-infection of CD4+ enriched T-cells. As for their effect on DCs, neither BmA nor ES-62 could enhance or inhibit DC maturation as determined by CD83, CD86 and HLA-DR expression, or the production of IL-6, IL-10, IL-12 and TNF-α. As expected, due to the unaltered DC phenotype, no differences were found in CD4+ T helper (Th) cell phenotypes induced by DCs treated with either BmA or ES-62. Moreover, the HIV-1 susceptibility of the Th-cell populations induced by BmA or ES-62 exposed DCs was unaffected for both CCR5- and CXCR4-using HIV-1 viruses. In conclusion, although BmA has the potential capacity to interfere with HIV-1 transmission or initial viral dissemination through preventing the virus from interacting with DCs, no differences in the Th-cell polarizing capacity of DCs exposed to BmA or ES-62 were observed. Neither antigenic source demonstrated beneficial or detrimental effects on the HIV-1 susceptibility of CD4+ Th-cells induced by exposed DCs. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

17. Schistosomes Induce Regulatory Features in Human and Mouse CD1dhi B Cells: Inhibition of Allergic Inflammation by IL-10 and Regulatory T Cells

Author

van der Vlugt, Luciën E. P. M., primary, Labuda, Lucja A., additional, Ozir-Fazalalikhan, Arifa, additional, Lievers, Ellen, additional, Gloudemans, Anouk K., additional, Liu, Kit-Yeng, additional, Barr, Tom A., additional, Sparwasser, Tim, additional, Boon, Louis, additional, Ngoa, Ulysse Ateba, additional, Feugap, Eliane Ngoune, additional, Adegnika, Ayola A., additional, Kremsner, Peter G., additional, Gray, David, additional, Yazdanbakhsh, Maria, additional, and Smits, Hermelijn H., additional

Published
2012
Full Text
View/download PDF

18. Enhanced Pro-Inflammatory Cytokine Responses following Toll-Like-Receptor Ligation in Schistosoma haematobium-Infected Schoolchildren from Rural Gabon

Author

Meurs, Lynn, primary, Labuda, Lucja, additional, Amoah, Abena Serwaa, additional, Mbow, Moustapha, additional, Ngoa, Ulysse Ateba, additional, Boakye, Daniel Adjei, additional, Mboup, Souleymane, additional, Dièye, Tandakha Ndiaye, additional, Mountford, Adrian P., additional, Turner, Joseph D., additional, Kremsner, Peter Gottfried, additional, Polman, Katja, additional, Yazdanbakhsh, Maria, additional, and Adegnika, Ayola Akim, additional

Published
2011
Full Text
View/download PDF

23. CD4+CD25hiFOXP3+ Cells in Cord Blood of Neonates Born from Filaria Infected Mother Are Negatively Associated with CD4+Tbet+ and CD4+RORγt+ T Cells.

Author

Ateba-Ngoa, Ulysse, Mombo-Ngoma, Ghyslain, Zettlmeissl, Eva, van der Vlugt, Luciën E. P. M., de Jong, Sanne, Matsiegui, Pierre-Blaise, Ramharter, Michael, Kremsner, Peter G., Yazdanbakhsh, Maria, and Adegnika, Ayola Akim

Subjects
NEWBORN infants, CD4 antigen, CD25 antigen, CORD blood, FILARIASIS, T cells
Abstract

Background: Children who have been exposed in utero to maternal filarial infection are immunologically less responsive to filarial antigens, have less pathology, and are more susceptible to acquire infection than offspring of uninfected mothers. Moreover children from filaria infected mothers have been shown to be less responsive to vaccination as a consequence of an impairment of their immune response. However, it is not well known how in utero exposure to parasite antigens affects cellular immune responses. Methodology: Here, 30 pregnant women were examined for the presence of microfilaria of Loa loa and Mansonella perstans in peripheral blood. At delivery, cord blood mononuclear cells (CBMC) were obtained and the CD4+T cells were phenotyped by expression of the transcription factors Tbet, RORγt, and FOXP3. Results: No significant difference was observed between newborns from infected versus uninfected mothers in the frequencies of total CD4+T cells and CD4+T cells subsets including CD4+Tbet+, CD4+RORγt+ T and CD4+CD25hiFOXP3+ T cells. However, there was a negative association between CD4+CD25hiFOXP3+T cells and CD4+Tbet+ as well as CD4+RORγt+ T cells in the infected group only (B = −0.242, P = 0.002; B = −0.178, P = 0.013 respectively). Conclusion: Our results suggest that filarial infection during pregnancy leads to an expansion of functionally active regulatory T cells that keep TH1 and TH17 in check. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

24. Both Very Low- and Very High In Vitro Cytokine Responses Were Associated with Infant Death in Low-Birth-Weight Children from Guinea Bissau.

Author

Andersen, Andreas, Jensen, Kristoffer J., Erikstrup, Christian, Ravn, Henrik, Fisker, Ane B., Lisse, Ida M., Sartono, Erliyani, Aaby, Peter, Yazdanbakhsh, Maria, and Benn, Christine S.

Subjects
CYTOKINES, NEONATAL mortality, LOW birth weight, IMMUNITY, RANDOMIZED controlled trials, IN vitro studies
Abstract

Background: The mechanisms behind heterologous immunity and non-specific effects of vaccines on mortality are not well understood. We examined associations between cytokine responses and subsequent mortality in low-birth-weight infants in Guinea-Bissau. Methods: A low-birth-weight trial randomized children to Bacille Calmette-Guérin (BCG) at birth or later according to local policy. Blood samples were obtained from a sub-group at age 6 weeks. Interleukin (IL)-5, IL-10, IL-13, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α were measured in whole-blood cell cultures stimulated with lipopolysaccharide (LPS), phytohaemagglutinin (PHA), or purified protein derivative (PPD). The outcome was mortality between bleeding and 1 year of age. Non-linear associations between cytokine responses and mortality were examined. Results: Cytokine measurements were available from 390 children. The mortality rate (MR) was high (6.8/100 person-years-observation (PYO)). Both low and high cytokine responses to LPS and PHA were associated with high mortality (MR up to 25/100 PYO in the lowest 10% and 9.2/100 PYO in the highest 10%). In BCG-vaccinated children, higher IFN-γ responses to PPD were associated with better survival (MR ratio = 0.43 (0.24–0.77)). Conclusions: Data presented a rare opportunity to explore associations between cytokine responses and mortality. Both low and high cytokine responses were associated with high mortality; a balanced response to invading pathogens seems preferable. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

25. Schistosomes Induce Regulatory Features in Human and Mouse CD1dhi B Cells: Inhibition of Allergic Inflammation by IL-10 and Regulatory T Cells.

Author

Van der Vlugt, Luciën E. P. M., Labuda, Lucja A., Ozir-Fazalalikhan, Arifa, Lievers, Ellen, Gloudemans, Anouk K., Liu, Kit-Yeng, Barr, Tom A., Sparwasser, Tim, Boon, Louis, Ngoa, Ulysse Ateba, Feugap, Eliane Ngoune, Adegnika, Ayola A., Kremsner, Peter G., Gray, David, Yazdanbakhsh, Maria, and Smits, Hermelijn H.

Subjects
LYMPHOCYTES, B cells, SCHISTOSOMA, OOGENESIS, SCHISTOSOMATIDAE, INFLAMMATION, CARDIOPULMONARY system
Abstract

Chronic helminth infections, such as schistosomes, are negatively associated with allergic disorders. Here, using B cell IL- 10-deficient mice, Schistosoma mansoni-mediated protection against experimental ovalbumin-induced allergic airway inflammation (AAI) was shown to be specifically dependent on IL-10-producing B cells. To study the organs involved, we transferred B cells from lungs, mesenteric lymph nodes or spleen of OVA-infected mice to recipient OVA-sensitized mice, and showed that both lung and splenic B cells reduced AAI, but only splenic B cells in an IL-10-dependent manner. Although splenic B cell protection was accompanied by elevated levels of pulmonary FoxP3+ regulatory T cells, in vivo ablation of FoxP3+ T cells only moderately restored AAI, indicating an important role for the direct suppressory effect of regulatory B cells. Splenic marginal zone CD1d+ B cells proved to be the responsible splenic B cell subset as they produced high levels of IL-10 and induced FoxP3+ T cells in vitro. Indeed, transfer of CD1d+ MZ-depleted splenic B cells from infected mice restored AAI. Markedly, we found a similarly elevated population of CD1dhi B cells in peripheral blood of Schistosoma haematobium-infected Gabonese children compared to uninfected children and these cells produced elevated levels of IL-10. Importantly, the number of IL-10-producing CD1dhi B cells was reduced after anti-schistosome treatment. This study points out that in both mice and men schistosomes have the capacity to drive the development of IL-10-producing regulatory CD1dhi B cells and furthermore, these are instrumental in reducing experimental allergic inflammation in mice. [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results