8 results on '"Yong Suk Cho"'
Search Results
2. Development of a risk prediction model (Hangang) and comparison with clinical severity scores in burn patients.
- Author
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Youngmin Kim, Dohern Kym, Jun Hur, Jinwoo Jeon, Jaechul Yoon, Haejun Yim, Yong Suk Cho, and Wook Chun
- Subjects
Medicine ,Science - Abstract
PURPOSE:The purpose of this study was to develop a new prediction model to reflect the risk of mortality and severity of disease and to evaluate the ability of the developed model to predict mortality among adult burn patients. METHODS:This study included 2009 patients aged more than 18 years who were admitted to the intensive care unit (ICU) within 24 hours after a burn. We divided the patients into two groups; those admitted from January 2007 to December 2013 were included in the derivation group and those admitted from January 2014 to September 2017 were included in the validation group. Shrinkage methods with 10-folds cross-validation were performed to identify variables and limit overfitting of the model. The discrimination was analyzed using the area under the curve (AUC) of the receiver operating characteristic curve. The Brier score, integrated discrimination improvement (IDI), and net reclassification improvement (NRI) were also calculated. The calibration was analyzed using the Hosmer-Lemeshow goodness-of-fit test (HL test). The clinical usefulness was evaluated using a decision-curve analysis. RESULTS:The Hangang model showed good calibration with the HL test (χ2 = 8.785, p = 0.361); the highest AUC and the lowest Brier score were 0.943 and 0.068, respectively. The NRI and IDI were 0.124 (p-value = 0.003) and 0.079 (p-value
- Published
- 2019
- Full Text
- View/download PDF
3. Diagnostic performance of plasma and urine neutrophil gelatinase-associated lipocalin, cystatin C, and creatinine for acute kidney injury in burn patients: A prospective cohort study.
- Author
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Youngmin Kim, Yong Suk Cho, Dohern Kym, Jaechul Yoon, Haejun Yim, Jun Hur, and Wook Chun
- Subjects
Medicine ,Science - Abstract
BACKGROUND:Diagnosing acute kidney injury quickly is imperative since it is known as an independent risk factor for mortality in burn patients. We evaluated the diagnostic power of creatinine, cystatin, serum and urine neutrophil gelatinase-associated lipocalin at different time periods and observed the changes from baseline for each biomarker. METHODS:This was a prospective observation study from January 2015 to February 2016. A total of 84 patients were enrolled consecutively. Serum creatinine, serum cystatin C, and serum and urine neutrophil gelatinase-associated lipocalin were measured at admission, 7th, 14th, 21st, and 28th days after admission. All samples were collected until acute kidney injury developed. RESULTS:Acute kidney injury developed in 35 patients. The mean age was 49.6 years with a male predominance. The median urine neutrophil gelatinase-associated lipocalin was the lowest (11.6 ng/dL) at admission, and the highest at 85.5 ng/dL on day 7. Mean creatinine level was the highest (0.88 mg/dL) at admission and the median creatinine level was the lowest (0.56 mg/dL) on the 14th day. The area under the curve of creatinine levels was the highest with 0.857 during the 1st week. The area under the curve of urine neutrophil gelatinase-associated lipocalin was the highest with 0.803 during the 5th week. CONCLUSIONS:Within 1 week of acute kidney injury, creatinine level was the optimal biomarker for diagnosis while urine neutrophil gelatinase-associated lipocalin showed better diagnostic performance following the 4- week period.
- Published
- 2018
- Full Text
- View/download PDF
4. Does inhalation injury predict mortality in burns patients or require redefinition?
- Author
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Youngmin Kim, Dohern Kym, Jun Hur, Jaechul Yoon, Haejun Yim, Yong Suk Cho, and Wook Chun
- Subjects
Medicine ,Science - Abstract
Inhalation injury is known to be an important factor in predicting mortality in burns patients. However, the diagnosis is complicated by the heterogeneous presentation and inability to determine the severity of inhalation injury. The purpose of this study was to identify clinical features of inhalation injury that affect mortality and the values that could predict the outcome more precisely in burns patients with inhalation injury. This retrospective observational study included 676 burns patients who were over 18 years of age and hospitalized in the Burns Intensive Care Unit between January 2012 and December 2015. We analyzed variables that are already known to be prognostic factors (age, percentage of total body surface area (%TBSA) burned, and inhalation injury) and factors associated with inhalation injury (carboxyhemoglobin and PaO2/FiO2 [PF] ratio) by univariate and multivariate logistic regression. Age group (odds ratio [OR] 1.069, p
- Published
- 2017
- Full Text
- View/download PDF
5. Diagnostic performance of plasma and urine neutrophil gelatinase-associated lipocalin, cystatin C, and creatinine for acute kidney injury in burn patients: A prospective cohort study
- Author
-
Young-Min Kim, Yong Suk Cho, Wook Chun, Jun Hur, Dohern Kym, Jaechul Yoon, and Haejun Yim
- Subjects
Male ,Time Factors ,Critical Care and Emergency Medicine ,Physiology ,Neutrophils ,030232 urology & nephrology ,lcsh:Medicine ,Urine ,Lipocalin ,Gastroenterology ,Biochemistry ,chemistry.chemical_compound ,White Blood Cells ,0302 clinical medicine ,Animal Cells ,Medicine and Health Sciences ,Medicine ,Prospective Studies ,lcsh:Science ,Prospective cohort study ,Trauma Medicine ,Burn Management ,Multidisciplinary ,biology ,Area under the curve ,Acute kidney injury ,Acute Kidney Injury ,Middle Aged ,Body Fluids ,Creatinine ,Disease Progression ,Biomarker (medicine) ,Female ,Anatomy ,Cellular Types ,Burns ,Traumatic Injury ,Research Article ,Adult ,medicine.medical_specialty ,Immune Cells ,Immunology ,Dermatology ,Sensitivity and Specificity ,03 medical and health sciences ,Lipocalin-2 ,Diagnostic Medicine ,Internal medicine ,Humans ,Cystatin C ,Blood Cells ,business.industry ,lcsh:R ,Biology and Life Sciences ,030208 emergency & critical care medicine ,Kidneys ,Renal System ,Cell Biology ,medicine.disease ,chemistry ,biology.protein ,lcsh:Q ,business ,Biomarkers - Abstract
Background Diagnosing acute kidney injury quickly is imperative since it is known as an independent risk factor for mortality in burn patients. We evaluated the diagnostic power of creatinine, cystatin, serum and urine neutrophil gelatinase-associated lipocalin at different time periods and observed the changes from baseline for each biomarker. Methods This was a prospective observation study from January 2015 to February 2016. A total of 84 patients were enrolled consecutively. Serum creatinine, serum cystatin C, and serum and urine neutrophil gelatinase-associated lipocalin were measured at admission, 7th, 14th, 21st, and 28th days after admission. All samples were collected until acute kidney injury developed. Results Acute kidney injury developed in 35 patients. The mean age was 49.6 years with a male predominance. The median urine neutrophil gelatinase-associated lipocalin was the lowest (11.6 ng/dL) at admission, and the highest at 85.5 ng/dL on day 7. Mean creatinine level was the highest (0.88 mg/dL) at admission and the median creatinine level was the lowest (0.56 mg/dL) on the 14th day. The area under the curve of creatinine levels was the highest with 0.857 during the 1st week. The area under the curve of urine neutrophil gelatinase-associated lipocalin was the highest with 0.803 during the 5th week. Conclusions Within 1 week of acute kidney injury, creatinine level was the optimal biomarker for diagnosis while urine neutrophil gelatinase-associated lipocalin showed better diagnostic performance following the 4- week period.
- Published
- 2018
6. Does inhalation injury predict mortality in burns patients or require redefinition?
- Author
-
Young-Min Kim, Yong Suk Cho, Jun Hur, Dohern Kym, Jaechul Yoon, Wook Chun, and Haejun Yim
- Subjects
Male ,Critical Care and Emergency Medicine ,Physiology ,medicine.medical_treatment ,lcsh:Medicine ,Poison control ,law.invention ,0302 clinical medicine ,Mathematical and Statistical Techniques ,law ,Medicine and Health Sciences ,030212 general & internal medicine ,Survivors ,lcsh:Science ,Trauma Medicine ,Burn Management ,Multidisciplinary ,Inhalation ,Mortality rate ,Respiration ,Middle Aged ,Smoke Inhalation Injury ,Intensive care unit ,Hospitals ,Respiratory Function Tests ,Intensive Care Units ,Chemistry ,Anesthesia ,Physical Sciences ,Regression Analysis ,Female ,Anatomy ,Burns ,Traumatic Injury ,Statistics (Mathematics) ,Research Article ,Chemical Elements ,medicine.medical_specialty ,Death Rates ,Dermatology ,Research and Analysis Methods ,03 medical and health sciences ,Population Metrics ,medicine ,Humans ,Risk factor ,Statistical Methods ,Demography ,Mechanical ventilation ,Population Biology ,business.industry ,lcsh:R ,Biology and Life Sciences ,030208 emergency & critical care medicine ,Odds ratio ,Survival Analysis ,Surgery ,Oxygen ,Health Care ,Logistic Models ,Health Care Facilities ,Face ,Multivariate Analysis ,lcsh:Q ,business ,Physiological Processes ,Total body surface area ,Head ,Mathematics - Abstract
Inhalation injury is known to be an important factor in predicting mortality in burns patients. However, the diagnosis is complicated by the heterogeneous presentation and inability to determine the severity of inhalation injury. The purpose of this study was to identify clinical features of inhalation injury that affect mortality and the values that could predict the outcome more precisely in burns patients with inhalation injury. This retrospective observational study included 676 burns patients who were over 18 years of age and hospitalized in the Burns Intensive Care Unit between January 2012 and December 2015. We analyzed variables that are already known to be prognostic factors (age, percentage of total body surface area (%TBSA) burned, and inhalation injury) and factors associated with inhalation injury (carboxyhemoglobin and PaO2/FiO2 [PF] ratio) by univariate and multivariate logistic regression. Age group (odds ratio [OR] 1.069, p
- Published
- 2017
7. Development of a risk prediction model (Hangang) and comparison with clinical severity scores in burn patients
- Author
-
Dohern Kym, Yong Suk Cho, Jun Hur, Jaechul Yoon, Jinwoo Jeon, Wook Chun, Haejun Yim, and Young-Min Kim
- Subjects
Male ,Critical Care and Emergency Medicine ,Physiology ,Epidemiology ,Severity of Illness Index ,law.invention ,Mathematical and Statistical Techniques ,0302 clinical medicine ,Risk Factors ,law ,Medicine and Health Sciences ,Risk of mortality ,Bile ,Clinical severity ,Hospital Mortality ,030212 general & internal medicine ,Trauma Medicine ,Burn Management ,Multidisciplinary ,Respiration ,Statistics ,Age Factors ,Area under the curve ,Middle Aged ,Prognosis ,Intensive care unit ,Hospitals ,Body Fluids ,Net reclassification improvement ,Survival Rate ,Intensive Care Units ,Inhalation ,Brier score ,Physical Sciences ,Cohort ,Medicine ,Female ,Anatomy ,Burns ,Traumatic Injury ,Research Article ,Adult ,medicine.medical_specialty ,Death Rates ,Science ,Clinical Decision-Making ,Dermatology ,Research and Analysis Methods ,Models, Biological ,Risk Assessment ,Decision Support Techniques ,Young Adult ,03 medical and health sciences ,Sex Factors ,Population Metrics ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Statistical Methods ,Aged ,Population Biology ,Receiver operating characteristic ,business.industry ,Biology and Life Sciences ,Bilirubin ,030208 emergency & critical care medicine ,Health Care ,ROC Curve ,Health Care Facilities ,Medical Risk Factors ,Physiological Processes ,business ,Mathematics ,Forecasting - Abstract
Purpose The purpose of this study was to develop a new prediction model to reflect the risk of mortality and severity of disease and to evaluate the ability of the developed model to predict mortality among adult burn patients. Methods This study included 2009 patients aged more than 18 years who were admitted to the intensive care unit (ICU) within 24 hours after a burn. We divided the patients into two groups; those admitted from January 2007 to December 2013 were included in the derivation group and those admitted from January 2014 to September 2017 were included in the validation group. Shrinkage methods with 10-folds cross-validation were performed to identify variables and limit overfitting of the model. The discrimination was analyzed using the area under the curve (AUC) of the receiver operating characteristic curve. The Brier score, integrated discrimination improvement (IDI), and net reclassification improvement (NRI) were also calculated. The calibration was analyzed using the Hosmer-Lemeshow goodness-of-fit test (HL test). The clinical usefulness was evaluated using a decision-curve analysis. Results The Hangang model showed good calibration with the HL test (χ2 = 8.785, p = 0.361); the highest AUC and the lowest Brier score were 0.943 and 0.068, respectively. The NRI and IDI were 0.124 (p-value = 0.003) and 0.079 (p-value
- Published
- 2019
8. Subgroup analysis of continuous renal replacement therapy in severely burned patients
- Author
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Jaechul Yoon, Haejun Yim, Yong-Suk Cho, Dohern Kym, Wook Chun, Young-Min Kim, and Jun Hur
- Subjects
Male ,Critical Care and Emergency Medicine ,Physiology ,medicine.medical_treatment ,030232 urology & nephrology ,lcsh:Medicine ,Urine ,Pathology and Laboratory Medicine ,urologic and male genital diseases ,Biochemistry ,Severity of Illness Index ,law.invention ,chemistry.chemical_compound ,0302 clinical medicine ,Animal Cells ,law ,Medicine and Health Sciences ,Medicine ,lcsh:Science ,Trauma Medicine ,Acidosis ,Burn Management ,Multidisciplinary ,Mortality rate ,Acute kidney injury ,Middle Aged ,Intensive care unit ,Body Fluids ,Renal Replacement Therapy ,Blood ,Creatinine ,Female ,Anatomy ,Cellular Types ,medicine.symptom ,Burns ,Traumatic Injury ,Research Article ,Platelets ,Adult ,medicine.medical_specialty ,Death Rates ,Urology ,Dermatology ,03 medical and health sciences ,Signs and Symptoms ,Population Metrics ,Diagnostic Medicine ,Sepsis ,Humans ,Renal replacement therapy ,Aged ,Retrospective Studies ,Blood Cells ,Population Biology ,business.industry ,lcsh:R ,Biology and Life Sciences ,030208 emergency & critical care medicine ,Retrospective cohort study ,Cell Biology ,medicine.disease ,Survival Analysis ,chemistry ,lcsh:Q ,business ,Biomarkers - Abstract
Continuous renal replacement therapy (CRRT) is administered to critically ill patients with renal injuries as renal replacement or renal support. We aimed to identify predictors of mortality among burn patients receiving CRRT, and to investigate clinical differences according to acute kidney injury (AKI) status. This retrospective observational study evaluated 216 Korean burn patients who received CRRT at a burn intensive care unit. Patients were categorized by AKI status. Data were collected regarding arterial pH, laboratory results, ratio of arterial oxygen partial pressure to fractional inspired oxygen (PF ratio), and urine production. Among surviving patients, CRRT duration and the sequential organ failure assessment score were 6.5 days and 4.7 in the non-AKI group and 23.4 days and 7.4 in the AKI group, respectively (p = 0.003 and p = 0.008). On logistic regression analyses, mortality was significantly associated with a pH of 5.0 mEg/L (p = 0.045), creatinine levels of >2.0 mg/dL (p = 0.011), lactate levels of >2 mmol/L (p2 mmol/L, and a platelet count of 2 mg/dL. In the non-AKI group, poor outcomes were associated with lactate levels of >1.5 mmol/L, a PF ratio of 1.2 mg/dL. Duration of the CRRT application and the requirement for either renal replacement or renal support at the initiation of CRRT application are important considerations depending on its application.
- Published
- 2017
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