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692 results on '"ZHANG, Xiao"'

1. Feature extraction method of EEG based on wavelet packet reconstruction and deep learning model of VR motion sickness feature classification and prediction.

Author

Luo, Shuhang, Ren, Peng, Wu, Jiawei, Wu, Xiang, and Zhang, Xiao

Subjects
DEEP learning, MOTION sickness, FEATURE extraction, ELECTROENCEPHALOGRAPHY, VIRTUAL reality, CLASSIFICATION
Abstract

The surging popularity of virtual reality (VR) technology raises concerns about VR-induced motion sickness, linked to discomfort and nausea in simulated environments. Our method involves in-depth analysis of EEG data and user feedback to train a sophisticated deep learning model, utilizing an enhanced GRU network for identifying motion sickness patterns. Following comprehensive data pre-processing and feature engineering to ensure input accuracy, a deep learning model is trained using supervised and unsupervised techniques for classifying and predicting motion sickness severity. Rigorous training and validation procedures confirm the model's robustness across diverse scenarios. Research results affirm our deep learning model's 84.9% accuracy in classifying and predicting VR-induced motion sickness, surpassing existing models. This information is vital for improving the VR experience and advancing VR technology. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Clonal integration of stress signal induces morphological and physiological response of root within clonal network

Author

Duan, Su-Juan, primary, Du, Jie, additional, Yu, Dong-Wei, additional, Pei, Xiang-Jun, additional, Yin, Da-Qiu, additional, Wang, Shi-Jun, additional, Tao, Qi-Zhong, additional, Dan, Yi, additional, Zhang, Xiao-Chao, additional, Deng, Jie, additional, Chen, Jin-Song, additional, Wei, Qing, additional, and Lei, Ning-Fei, additional

Published
2024
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6. A conserved sequence extending motif III of the motor domain in the Snf2-family DNA translocase Rad54 is critical for ATPase activity.

Author

Zhang, Xiao-Ping, Janke, Ryan, Kingsley, James, Luo, Jerry, Fasching, Clare, Ehmsen, Kirk T, and Heyer, Wolf-Dietrich

Subjects
Saccharomyces cerevisiae, DNA Damage, DNA Repair Enzymes, DNA Helicases, Saccharomyces cerevisiae Proteins, Transcription Factors, DNA Repair, Recombination, Genetic, Conserved Sequence, Rad51 Recombinase, Adenosine Triphosphatases, Recombination, Genetic, General Science & Technology
Abstract

Rad54 is a dsDNA-dependent ATPase that translocates on duplex DNA. Its ATPase function is essential for homologous recombination, a pathway critical for meiotic chromosome segregation, repair of complex DNA damage, and recovery of stalled or broken replication forks. In recombination, Rad54 cooperates with Rad51 protein and is required to dissociate Rad51 from heteroduplex DNA to allow access by DNA polymerases for recombination-associated DNA synthesis. Sequence analysis revealed that Rad54 contains a perfect match to the consensus PIP box sequence, a widely spread PCNA interaction motif. Indeed, Rad54 interacts directly with PCNA, but this interaction is not mediated by the Rad54 PIP box-like sequence. This sequence is located as an extension of motif III of the Rad54 motor domain and is essential for full Rad54 ATPase activity. Mutations in this motif render Rad54 non-functional in vivo and severely compromise its activities in vitro. Further analysis demonstrated that such mutations affect dsDNA binding, consistent with the location of this sequence motif on the surface of the cleft formed by two RecA-like domains, which likely forms the dsDNA binding site of Rad54. Our study identified a novel sequence motif critical for Rad54 function and showed that even perfect matches to the PIP box consensus may not necessarily identify PCNA interaction sites.

Published
2013

7. Myotonia congenita mutation enhances the degradation of human CLC-1 chloride channels.

Author

Lee, Ting-Ting, Zhang, Xiao-Dong, Chuang, Chao-Chin, Chen, Jing-Jer, Chen, Yi-An, Chen, Shu-Ching, Chen, Tsung-Yu, and Tang, Chih-Yung

Subjects
Animals, COS Cells, Cell Membrane, Chloride Channels, Chlorocebus aethiops, Electrophysiological Phenomena, Endosomes, Gene Expression Regulation, HEK293 Cells, Humans, Lysosomes, Mutation, Myotonia Congenita, Proteolysis, Temperature
Abstract

Myotonia congenita is a hereditary muscle disorder caused by mutations in the human voltage-gated chloride (Cl(-)) channel CLC-1. Myotonia congenita can be inherited in an autosomal recessive (Becker type) or dominant (Thomsen type) fashion. One hypothesis for myotonia congenita is that the inheritance pattern of the disease is determined by the functional consequence of the mutation on the gating of CLC-1 channels. Several disease-related mutations, however, have been shown to yield functional CLC-1 channels with no detectable gating defects. In this study, we have functionally and biochemically characterized a myotonia mutant: A531V. Despite a gating property similar to that of wild-type (WT) channels, the mutant CLC-1 channel displayed a diminished whole-cell current density and a reduction in the total protein expression level. Our biochemical analyses further demonstrated that the reduced expression of A531V can be largely attributed to an enhanced proteasomal degradation as well as a defect in protein trafficking to surface membranes. Moreover, the A531V mutant protein also appeared to be associated with excessive endosomal-lysosomal degradation. Neither the reduced protein expression nor the diminished current density was rescued by incubating A531V-expressing cells at 27°C. These results demonstrate that the molecular pathophysiology of A531V does not involve anomalous channel gating, but rather a disruption of the balance between the synthesis and degradation of the CLC-1 channel protein.

Published
2013

13. The effects of GLP-1 receptor agonists on visceral fat and liver ectopic fat in an adult population with or without diabetes and nonalcoholic fatty liver disease: A systematic review and meta-analysis.

Author

Liao, Chao, Liang, Xinyin, Zhang, Xiao, and Li, Yao

Subjects
NON-alcoholic fatty liver disease, GLUCAGON-like peptide-1 agonists, TYPE 2 diabetes, ADIPOSE tissues, DIABETES, FAT
Abstract

Aim: To uncover the effect of GLP-1 receptor agonists (GLP-1 RAs) on the visceral- and hepatic fat content of adults. Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were searched from inception until November 2022. Randomized controlled trials (RCTs) of GLP-1Ras was extracted, including reports of effects on visceral adipose tissue and hepatic fat content in individuals with type 2 diabetes, non-type 2 diabetes, NAFLD (non-alcoholic fatty liver disease), and non-NAFLD. Meta-analyses used random-effects models. Results: 1736 individuals in the 30 qualified RCTs were included, comprising 1363 people with type 2 diabetes and 318 with NFLD. GLP-1 RAs reduced visceral adipose tissue (standard mean difference [SMD] = -0.59, 95% CI [-0.83, -0.36], P<0.00001) and hepatic fat content (weighted mean difference [WMD] = -3.09, 95% CI [-4.16, -2.02], P<0.00001) compared to other control treatment. Subgroup analysis showed that GLP-1Ras dramatically decreased visceral fat in patients with type 2 diabetes (SMD = -0.49, 95% CI [-0.69, -0.29] P<0.00001), NAFLD (SMD = -0.99, 95% CI [-1.64, -0.34] P = 0.003), non-type 2 diabetes (SMD = -1.38, 95% CI [-2.44, -0.32] P = 0.01), and non-NAFLD (SMD = -0.53, 95% CI [-0.78, -0.28] P<0.0001). GLP-1Ras reduced the liver fat level of type 2 diabetes (WMD = -3.15, 95% CI [-4.14, -2.15] P<0.00001), NAFLD (WMD = -3.83, 95% CI [-6.30, -1.37] P = 0.002), and type 2 diabetes with NAFLD (WMD = -4.27, 95% CI [-6.80, -1.74] P = 0.0009), while showed no impact on the hepatic fat content in non-Type 2 diabetes (WMD = −12.48, 95% CI [−45.19, 20.24] P = 0.45). Conclusions: LP-1 RAs significantly reduce visceral- and liver fat content in adults. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Multisite verification of the accuracy of a multi-gene next generation sequencing panel for detection of mutations and copy number alterations in solid tumours

Author

Bartlett, John, primary, Amemiya, Yutaka, additional, Arts, Heleen, additional, Bayani, Jane, additional, Eng, Barry, additional, Grafodatskaya, Daria, additional, Kamel Reid, Suzanne, additional, Lariviere, Mathieu, additional, Lo, Bryan, additional, McClure, Rebecca, additional, Mittal, Vinay, additional, Sadikovic, Bekim, additional, Sadis, Seth, additional, Seth, Arun, additional, Smith, Jeff, additional, Zhang, Xiao, additional, and Feilotter, Harriet, additional

Published
2021
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20. Risk factors for mortality of coronavirus disease-2019 (COVID-19) patients in two centers of Hubei province, China: A retrospective analysis

Author

Zhang, Xiao-Bin, primary, Hu, Lan, additional, Ming, Quan, additional, Wei, Xiao-Jie, additional, Zhang, Zhen-Yu, additional, Chen, Li-Da, additional, Wang, Ming-Hui, additional, Yao, Weng-Zhen, additional, Huang, Qiu-Fen, additional, Ye, Zhang-Qiang, additional, Cai, Yu-Qing, additional, and Zeng, Hui-Qing, additional

Published
2021
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26. A comprehensive analysis of metabolomics and transcriptomics in non-small cell lung cancer

Author

Tian Xin, Chen Ruiying, Zhu Zijia, Li Ze-Yun, Yuan Yongliang, Zhang Xiao-jian, and Zhang Ji

Subjects
0301 basic medicine, Oncology, Male, Lung Neoplasms, Biochemistry, Lung and Intrathoracic Tumors, Transcriptome, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Medicine and Health Sciences, Metabolites, Multidisciplinary, Area under the curve, Genomics, Middle Aged, 030220 oncology & carcinogenesis, Purine Metabolism, Medicine, Female, Metabolic Pathways, Transcriptome Analysis, Research Article, Adult, medicine.medical_specialty, Science, 03 medical and health sciences, Metabolomics, Internal medicine, medicine, Carcinoma, Genetics, Humans, Lung cancer, Aged, business.industry, Gene Expression Profiling, Cancers and Neoplasms, Biology and Life Sciences, Computational Biology, medicine.disease, Genome Analysis, respiratory tract diseases, Non-Small Cell Lung Cancer, Gene expression profiling, Amino Acid Metabolism, Metabolic pathway, 030104 developmental biology, Metabolism, Cancer cell, business, Biomarkers
Abstract

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer death globally. More accurate and reliable diagnostic methods/biomarkers are urgently needed. Joint application of metabolomics and transcriptomics technologies possesses the high efficiency of identifying key metabolic pathways and functional genes in lung cancer patients. In this study, we performed an untargeted metabolomics analysis of 142 NSCLC patients and 159 healthy controls; 35 identified metabolites were significantly different between NSCLC patients and healthy controls, of which 6 metabolites (hypoxanthine, inosine, L-tryptophan, indoleacrylic acid, acyl-carnitine C10:1, and lysoPC(18:2)) were chosen as combinational potential biomarkers for NSCLC. The area under the curve (AUC) value, sensitivity (SE), and specificity (SP) of these six biomarkers were 0.99, 0.98, and 0.99, respectively. Potential diagnostic implications of the metabolic characteristics in NSCLC was studied. The metabolomics results were further verified by transcriptomics analysis of 1027 NSCLC patients and 108 adjacent peritumoral tissues from TCGA database. This analysis identified 2202 genes with significantly different expressions in cancer cells compared to normal controls, which in turn defined pathways implicated in the metabolism of the compounds revealed by metabolomics analysis. We built a fully connected network of metabolites and genes, which shows a good correspondence between the transcriptome analysis and the metabolites selected for diagnosis. In conclusion, this work provides evidence that the metabolic biomarkers identified may be used for NSCLC diagnosis and screening. Comprehensive analysis of metabolomics and transcriptomics data offered a validated and comprehensive understanding of metabolism in NSCLC.

Published
2019

47. Cold Pressor Stress Cardiac Magnetic Resonance Myocardial Flow Reserve Is Not Useful for Detection of Coronary Endothelial Dysfunction in Women with Signs and Symptoms of Ischemia and No Obstructive CAD

Author

Landes, Sofy, primary, Dela Cruz, Sherwin, additional, Wei, Janet, additional, AlBadri, Ahmed, additional, Shufelt, Chrisandra, additional, Mehta, Puja, additional, Thomson, Louise E., additional, Diniz, Marcio A., additional, Zhang, Xiao, additional, Petersen, John W., additional, Anderson, R. David, additional, Pepine, Carl J., additional, Berman, Daniel S., additional, and Bairey Merz, C. Noel, additional

Published
2017
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48. Effects of Mulching Tolerant Plant Straw on Soil Surface on Growth and Cadmium Accumulation of Galinsoga parviflora

Author

Ming’an Liao, Zhang Xiao, Yang Daiyu, Lijin Lin, Jing He, Ren Yajun, and Li Luo

Subjects
Environmental Engineering, Agricultural Irrigation, Applied Microbiology, Galinsoga parviflora, chemistry.chemical_element, lcsh:Medicine, Plantago asiatica, Plant Science, Asteraceae, Plant Roots, Soil, Soil pH, Plant Products, Botany, Soil Pollutants, Biomass, lcsh:Science, Cadmium, Multidisciplinary, biology, Plant Stems, lcsh:R, Soil chemistry, Biology and Life Sciences, Straw, Agriculture, biology.organism_classification, Agronomy, Phytoremediation, Plant Leaves, Horticulture, Chemistry, Biodegradation, Environmental, chemistry, Plant Physiology, Shoot, Physical Sciences, Engineering and Technology, lcsh:Q, Mulch, Bioremediation, Plant Shoots, Research Article, Biotechnology, Chemical Elements
Abstract

Pot and field experiments were conducted to study the effects of mulching with straw of cadmium (Cd) tolerant plants (Ranunculus sieboldii, Mazus japonicus, Clinopodium confine and Plantago asiatica) on growth and Cd accumulation of Galinsoga parviflora in Cd-contaminated soil. In the pot experiment, mulching with M. japonicus straw increased the root biomass, stem biomass, leaf biomass, shoot biomass, plant height and activities of antioxidant enzymes (superoxide dismutase, peroxidase and catalase) of G. parviflora compared with the control, whereas mulching with straws of R. sieboldii, C. confine and P. asiatica decreased these parameters. Straws of the four Cd-tolerant plants increased the Cd content in roots of G. parviflora compared with the control. However, only straws of M. japonicus and P. asiatica increased the Cd content in shoots of G. parviflora, reduced the soil pH, and increased the soil exchangeable Cd concentration. Straw of M. japonicus increased the amount of Cd extraction in stems, leaves and shoots of G. parviflora by 21.11%, 29.43% and 24.22%, respectively, compared with the control, whereas straws of the other three Cd-tolerant plants decreased these parameters. In the field experiment, the M. japonicus straw also increased shoot biomass, Cd content in shoots, and amount of Cd extraction in shoots of G. parviflora compared with the control. Therefore, straw of M. japonicus can be used to improve the Cd extraction ability of G. parviflora from Cd-contaminated soil.

Published
2014

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