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Your search keyword '"Zhou, Qiong"' showing total 18 results
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18 results on '"Zhou, Qiong"'

3. Scrub typhus, a disease with increasing threat in Guangdong, China

Author

Kou Jing, Wu De, Zhong Jian Min, Huang Ping, Corina Monagin, Ke Chang Wen, Zhou Qiong, Zhang Huan, and Lin Jin Yan

Subjects
China, Orientia tsutsugamushi, Molecular Sequence Data, lcsh:Medicine, Spleen, Disease, Scrub typhus, law.invention, Spatio-Temporal Analysis, law, Genotype, medicine, Prevalence, Animals, Humans, lcsh:Science, Polymerase chain reaction, Phylogeny, Multidisciplinary, biology, Geography, Incidence (epidemiology), Incidence, lcsh:R, biology.organism_classification, medicine.disease, bacterial infections and mycoses, Virology, Molecular Typing, medicine.anatomical_structure, Scrub Typhus, Population Surveillance, lcsh:Q, Nested polymerase chain reaction, Research Article
Abstract

There has been a rapid increase in the number of scrub typhus cases in Guangdong Province, China. For this reason, an epidemiologic study was conducted to understand the characteristics of scrub typhus epidemics in Guangdong. From 2006 to 2013, the incidence of human cases increased from 0.4321 to 3.5917 per 100,000 with a bimodal peak in human cases typically occurring between May and November. To detect the prevalence of Orientia tsutsugamushi among suspected human cases and rodents, we performed ELISA tests of IgM/IgG and nested PCR tests on 59 whole blood samples from the suspected cases and 112 spleen samples from the rodents. Suspected cases tested positive for anti-O. tsutsugamushi IgM and IgG 66.1% (39/59) and 50.8% (30/59) of the time, respectively. Additionally, 20.3% (12/59) of blood samples and 13.4% (15/112) of spleen samples were positive for PCR. Phylogenetic analysis revealed that there were four definable clusters among the 27 nucleotide sequences of the 56-kDa antigen genes: 44.4% Karp (12/27), 25.9% Kato (7/27), 22.2% Gilliam (6/27) and 7.4% TA763 (2/27). We concluded many suspected cases may result in diagnostic errors; therefore, it is necessary to perform laboratory tests on suspected cases in hospitals. The high infection rate of O. tsutsugamushi among the limited rodents tested suggested that further rodent sampling throughout the province is necessary to further define high-risk areas. Furthermore, the multiple co-circulating genotypes of O. tsutsugamushi play a key role in the pervasiveness of scrub typhus in the Guangdong area.

Published
2015

5. The Prognostic Value of Plasma Soluble ST2 in Hospitalized Chinese Patients with Heart Failure

Author

Zhang, Rongcheng, primary, Zhang, Yuhui, additional, Zhang, Jian, additional, An, Tao, additional, Huang, Yan, additional, Guo, Xiao, additional, Januzzi, James L., additional, Cappola, Thomas P., additional, Yin, Shijie, additional, Wang, Yunhong, additional, Zhou, Qiong, additional, Zou, Changhong, additional, Ji, Shiming, additional, and Lv, Rong, additional

Published
2014
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18. Regulation of CD4+ T Cells by Pleural Mesothelial Cells via Adhesion Molecule-Dependent Mechanisms in Tuberculous Pleurisy.

Author

Yuan, Ming-Li, Tong, Zhao-Hui, Jin, Xiao-Guang, Zhang, Jian-Chu, Wang, Xiao-Juan, Ma, Wan-Li, Yin, Wen, Zhou, Qiong, Ye, Hong, and Shi, Huan-Zhong

Subjects
TUBERCULOSIS patients, CD4 antigen, T cells, MESOTHELIUM, CELL adhesion, INTERFERONS
Abstract

Background:Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) have been demonstrated to be expressed on pleural mesothelial cells (PMCs), and to mediate leukocyte adhesion and migration; however, little is known about whether adhesion molecule-dependent mechanisms are involved in the regulation of CD4+ T cells by PMCs in tuberculous pleural effusion (TPE). Methods:Expressions of ICAM-1 and VCAM-1 on PMCs, as well as expressions of CD11a and CD29, the counter-receptors for ICAM-1 and VCAM-1, respectively, expressed on CD4+ T cells in TPE were determined using flow cytometry. The immune regulations on adhesion, proliferation, activation, selective expansion of CD4+ helper T cell subgroups exerted by PMCs via adhesion molecule-dependent mechanisms were explored. Results:Percentages of ICAM-1-positive and VCAM-1‒positive PMCs in TPE were increased compared with PMC line. Interferon-γ enhanced fluorescence intensity of ICAM-1, while IL-4 promoted VCAM-1 expression on PMCs. Percentages of CD11ahighCD4+ and CD29highCD4+ T cells in TPE significantly increased as compared with peripheral blood. Prestimulation of PMCs with anti‒ICAM-1 or ‒VCAM-1 mAb significantly inhibited adhesion, activation, as well as effector regulatory T cell expansion induced by PMCs. Conclusions:Our current data showed that adhesion molecule pathways on PMCs regulated adhesion and activation of CD4+ T cells, and selectively promoted the expansion of effector regulatory T cells. [ABSTRACT FROM AUTHOR]

Published
2013
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