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1. Hemoglobin targets for chronic kidney disease patients with anemia: a systematic review and meta-analysis.

Author

Zhou Jing, Yuan Wei-jie, Zhu Nan, Zhou Yi, and Wang Ling

Subjects
Medicine, Science
Abstract

BACKGROUND: Numerous studies have identified a relationship between hemoglobin (Hb) levels and mortality in patients with chronic kidney disease (CKD), which have raised concerns about the optimal Hb targets in correction of anemia. Our study is designed to investigate the potential effects of targeted Hb levels, aiming to give some evidence for therapy of renal anemia. METHODOLOGY/PRINCIPAL FINDINGS: A comprehensive search of Medline, Embase and the Cochrane Database of Systematic Reviews was performed in December 2011 and updated in February 2012 for any new trials. Randomized trials designed to evaluate effects of high (generally the Hb about 13.0 g/dL) and low Hb (generally the Hb about 10.0 g/dL) targets on clinical outcomes in CKD patients with anemia were collected. All statistical analysis was calculated using the RevMan software available free from the Cochrane Collaboration. 24 trials involving 10361 patients were identified. Our findings demonstrated a statistically significant increased risk of mortality in the high Hb levels (RR 1.18; 95% CI 1.02 to 1.37) while the high and low Hb groups were both treated with ESAs. Overall, compared with low Hb levels, high Hb levels are associated with increased risk of hypertension (RR 1.40; 95% CI 1.11 to 1.75), stroke (RR 1.73; 95% CI 1.31 to 2.29), and hospitalizations (RR 1.07; 95% CI 1.01 to 1.14). However, there are no significant differences in the risk of non-fatal myocardial infarction (RR 1. 13; 95% CI 0.79 to 1.61) and renal replacement therapy (RR 1. 00; 95% CI 0.85 to 1.18). CONCLUSIONS/SIGNIFICANCES: Targeting low Hb levels are beneficial to CKD patients especially in the predialysis population. The optimal Hb targets to aim for in CKD patients and at what Hb level the risks of adverse events begin to increase remain elusive. Future studies are still needed to elucidate these questions.

Published
2012
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3. A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication.

Author

Zhou, Jing, Bethune, Michael T, Malkova, Natalia, Sutherland, Alexander M, Comin-Anduix, Begonya, Su, Yapeng, Baltimore, David, Ribas, Antoni, and Heath, James R

Subjects
T-Lymphocytes, Animals, Mice, Inbred C57BL, Mice, Transgenic, Humans, Mice, Neoplasms, Adoptive Transfer, Flow Cytometry, Immunophenotyping, Lymphocyte Activation, Female, Heterografts, Inbred C57BL, Transgenic, General Science & Technology
Abstract

For adoptive cell transfer (ACT) immunotherapy of tumor-reactive T cells, an effective therapeutic outcome depends upon cell dose, cell expansion in vivo through a minimally differentiated phenotype, long term persistence, and strong cytolytic effector function. An incomplete understanding of the biological coupling between T cell expansion, differentiation, and response to stimulation hinders the co-optimization of these factors. We report on a biophysical investigation of how the short-term kinetics of T cell functional activation, through molecular stimulation and cell-cell interactions, competes with phenotype differentiation. T cells receive molecular stimulation for a few minutes to a few hours in bulk culture. Following this priming period, the cells are then analyzed at the transcriptional level, or isolated as single cells, with continuing molecular stimulation, within microchambers for analysis via 11-plex secreted protein assays. We resolve a rapid feedback mechanism, promoted by T cell-T cell contact interactions, which strongly amplifies T cell functional performance while yielding only minimal phenotype differentiation. When tested in mouse models of ACT, optimally primed T cells lead to complete tumor eradication. A similar kinetic process is identified in CD8+ and CD4+ T cells collected from a patient with metastatic melanoma.

Published
2018

25. Relationship between the exposure to cumulative cardiovascular health behaviors and factors and chronic kidney disease—The Kailuan study

Author

Hou, Jinhong, primary, Li, Junjuan, additional, Huang, Jinjie, additional, Lu, Chunhong, additional, Zhou, Jing, additional, Liu, Yang, additional, Wu, Shouling, additional, Wei, Fang, additional, Wang, Lihua, additional, Chen, Haiyan, additional, Yu, Haibo, additional, Wang, Zhe, additional, and Jiang, Aili, additional

Published
2018
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32. Interleukin-10 reorganizes the cytoskeleton of mature dendritic cells leading to their impaired biophysical properties and motilities

Author

Xu, Xiaoli, primary, Liu, Xianmei, additional, Long, Jinhua, additional, Hu, Zuquan, additional, Zheng, Qinni, additional, Zhang, Chunlin, additional, Li, Long, additional, Wang, Yun, additional, Jia, Yi, additional, Qiu, Wei, additional, Zhou, Jing, additional, Yao, Weijuan, additional, and Zeng, Zhu, additional

Published
2017
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33. Genetic variation of maturity groups and four E genes in the Chinese soybean mini core collection

Author

Li, Jicun, primary, Wang, Xiaobo, additional, Song, Wenwen, additional, Huang, Xinyang, additional, Zhou, Jing, additional, Zeng, Haiyan, additional, Sun, Shi, additional, Jia, Hongchang, additional, Li, Wenbin, additional, Zhou, Xinan, additional, Li, Suzhen, additional, Chen, Pengyin, additional, Wu, Cunxiang, additional, Guo, Yong, additional, Han, Tianfu, additional, and Qiu, Lijuan, additional

Published
2017
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44. Hemoglobin targets for chronic kidney disease patients with anemia: a systematic review and meta-analysis

Author

Wang Ling, Zhou Jing, Zhou Yi, Zhu Nan, and Yuan Wei-jie

Subjects
medicine.medical_specialty, Systematic Reviews, Anemia, Clinical Research Design, medicine.medical_treatment, Population, Myocardial Infarction, lcsh:Medicine, Cardiovascular, law.invention, Hemoglobins, Randomized controlled trial, law, Internal medicine, Chronic Kidney Disease, medicine, Humans, Renal replacement therapy, Renal Insufficiency, Chronic, Statistical Methods, education, Adverse effect, Intensive care medicine, lcsh:Science, education.field_of_study, Clinical Trials as Topic, Multidisciplinary, business.industry, Mortality rate, lcsh:R, medicine.disease, Stroke, Nephrology, Meta-analysis, Hypertension, Medicine, lcsh:Q, Meta-Analyses, business, Dialysis, Kidney disease, Research Article
Abstract

Background Numerous studies have identified a relationship between hemoglobin (Hb) levels and mortality in patients with chronic kidney disease (CKD), which have raised concerns about the optimal Hb targets in correction of anemia. Our study is designed to investigate the potential effects of targeted Hb levels, aiming to give some evidence for therapy of renal anemia. Methodology/Principal Findings A comprehensive search of Medline, Embase and the Cochrane Database of Systematic Reviews was performed in December 2011 and updated in February 2012 for any new trials. Randomized trials designed to evaluate effects of high (generally the Hb about 13.0 g/dL) and low Hb (generally the Hb about 10.0 g/dL) targets on clinical outcomes in CKD patients with anemia were collected. All statistical analysis was calculated using the RevMan software available free from the Cochrane Collaboration. 24 trials involving 10361 patients were identified. Our findings demonstrated a statistically significant increased risk of mortality in the high Hb levels (RR 1.18; 95% CI 1.02 to 1.37) while the high and low Hb groups were both treated with ESAs. Overall, compared with low Hb levels, high Hb levels are associated with increased risk of hypertension (RR 1.40; 95% CI 1.11 to 1.75), stroke (RR 1.73; 95% CI 1.31 to 2.29), and hospitalizations (RR 1.07; 95% CI 1.01 to 1.14). However, there are no significant differences in the risk of non-fatal myocardial infarction (RR 1. 13; 95% CI 0.79 to 1.61) and renal replacement therapy (RR 1. 00; 95% CI 0.85 to 1.18). Conclusions/Significances Targeting low Hb levels are beneficial to CKD patients especially in the predialysis population. The optimal Hb targets to aim for in CKD patients and at what Hb level the risks of adverse events begin to increase remain elusive. Future studies are still needed to elucidate these questions.

Published
2012

45. Unique features of odorant-binding proteins of the parasitoid wasp Nasonia vitripennis revealed by genome annotation and comparative analyses

Author

Vieira, Filipe G., Forêt, Sylvain, He, Xiaoli, Rozas, Julio, Field, Linda M., and Zhou, Jing-Jiang

Subjects
Physiogenomics, Anatomy and Physiology, Molecular Sequence Data, Wasps, lcsh:Medicine, Receptors, Odorant, Models, Biological, Olfactory Receptor Neurons, Evolution, Molecular, Integrated Control, Animals, Amino Acid Sequence, Cysteine, lcsh:Science, Biology, Genome Evolution, Ecosystem, Phylogeny, Evolutionary Biology, Chemical Ecology, Genome, Models, Statistical, Ecology, Models, Genetic, Sequence Homology, Amino Acid, fungi, lcsh:R, Computational Biology, Agriculture, Genomics, Comparative Genomics, Sustainable Agriculture, Functional Genomics, Protein Structure, Tertiary, Multigene Family, lcsh:Q, Pest Control, Pseudogenes, Research Article
Abstract

Insects are the most diverse group of animals on the planet, comprising over 90% of all metazoan life forms, and have adapted to a wide diversity of ecosystems in nearly all environments. They have evolved highly sensitive chemical senses that are central to their interaction with their environment and to communication between individuals. Understanding the molecular bases of insect olfaction is therefore of great importance from both a basic and applied perspective. Odorant binding proteins (OBPs) are some of most abundant proteins found in insect olfactory organs, where they are the first component of the olfactory transduction cascade, carrying odorant molecules to the olfactory receptors. We carried out a search for OBPs in the genome of the parasitoid wasp Nasonia vitripennis and identified 90 sequences encoding putative OBPs. This is the largest OBP family so far reported in insects. We report unique features of the N. vitripennis OBPs, including the presence and evolutionary origin of a new subfamily of double-domain OBPs (consisting of two concatenated OBP domains), the loss of conserved cysteine residues and the expression of pseudogenes. This study also demonstrates the extremely dynamic evolution of the insect OBP family: (i) the number of different OBPs can vary greatly between species; (ii) the sequences are highly diverse, sometimes as a result of positive selection pressure with even the canonical cysteines being lost; (iii) new lineage specific domain arrangements can arise, such as the double domain OBP subfamily of wasps and mosquitoes.

Published
2012

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