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Your search keyword '"Zhu, Xiao-Dong"' showing total 10 results
Start Over Author "Zhu, Xiao-Dong" Journal plos one
10 results on '"Zhu, Xiao-Dong"'

3. Incomplete Radiofrequency Ablation Enhances Invasiveness and Metastasis of Residual Cancer of Hepatocellular Carcinoma Cell HCCLM3 via Activating β-Catenin Signaling

Author

Zhang, Ning, primary, Wang, Lu, additional, Chai, Zong-Tao, additional, Zhu, Zi-Man, additional, Zhu, Xiao-Dong, additional, Ma, De-Ning, additional, Zhang, Qiang-Bo, additional, Zhao, Yi-Ming, additional, Wang, Miao, additional, Ao, Jian-Yang, additional, Ren, Zheng-Gang, additional, Gao, Dong-Mei, additional, Sun, Hui-Chuan, additional, and Tang, Zhao-You, additional

Published
2014
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4. MicroRNA-26a Inhibits Angiogenesis by Down-Regulating VEGFA through the PIK3C2α/Akt/HIF-1α Pathway in Hepatocellular Carcinoma

Author

Chai, Zong-Tao, primary, Kong, Jian, additional, Zhu, Xiao-Dong, additional, Zhang, Yuan-Yuan, additional, Lu, Lu, additional, Zhou, Jia-Min, additional, Wang, Long-Rong, additional, Zhang, Ke-Zhi, additional, Zhang, Qiang-Bo, additional, Ao, Jian-Yang, additional, Wang, Miao, additional, Wu, Wei-Zhong, additional, Wang, Lu, additional, Tang, Zhao-You, additional, and Sun, Hui-Chuan, additional

Published
2013
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5. Aspirin Minimized the Pro-Metastasis Effect of Sorafenib and Improved Survival by Up-Regulating HTATIP2 in Hepatocellular Carcinoma

Author

Lu, Lu, primary, Sun, Hui-Chuan, additional, Zhang, Wei, additional, Chai, Zong-Tao, additional, Zhu, Xiao-Dong, additional, Kong, Ling-Qun, additional, Wang, Wen-Quan, additional, Zhang, Ke-Zhi, additional, Zhang, Yuan-Yuan, additional, Zhang, Qiang-Bo, additional, Ao, Jian-Yang, additional, Li, Jia-Qi, additional, Wang, Lu, additional, Wu, Wei-Zhong, additional, and Tang, Zhao-You, additional

Published
2013
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9. Suppression of Natural Killer Cells by Sorafenib Contributes to Prometastatic Effects in Hepatocellular Carcinoma

Author

Zhang, Qiang-Bo, primary, Sun, Hui-Chuan, additional, Zhang, Ke-Zhi, additional, Jia, Qing-An, additional, Bu, Yang, additional, Wang, Miao, additional, Chai, Zong-Tao, additional, Zhang, Quan-Bao, additional, Wang, Wen-Quan, additional, Kong, Ling-Qun, additional, Zhu, Xiao-dong, additional, Lu, Lu, additional, Wu, Wei-Zhong, additional, Wang, Lu, additional, and Tang, Zhao-You, additional

Published
2013
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10. Aspirin Minimized the Pro-Metastasis Effect of Sorafenib and Improved Survival by Up-Regulating HTATIP2 in Hepatocellular Carcinoma

Author

Lu, Lu, Sun, Hui-Chuan, Zhang, Wei, Chai, Zong-Tao, Zhu, Xiao-Dong, Kong, Ling-Qun, Wang, Wen-Quan, Zhang, Ke-Zhi, Zhang, Yuan-Yuan, Zhang, Qiang-Bo, Ao, Jian-Yang, Li, Jia-Qi, Wang, Lu, Wu, Wei-Zhong, and Tang, Zhao-You

Subjects
ASPIRIN, METASTASIS, CARBOXAMIDES, GENETIC regulation, LIVER cancer, TUMOR suppressor genes, CYCLOOXYGENASE genetics, LABORATORY mice, PREVENTION
Abstract

Background & Aims: We previously demonstrated the pro-metastasis effect of sorafenib in hepatocellular carcinoma (HCC), which is mediated by down-regulation of tumor suppressor HTATIP2. The aim of the present study was to determine whether aspirin minimizes this effect and improves survival. Methods: The effects of sorafenib, aspirin, and combined sorafenib and aspirin were observed in HCCLM3 and HepG2 xenograft nude mice. Tumor growth, intrahepatic metastasis (IHM), lung metastasis, and survival were assessed. Polymerase chain reaction (PCR) array, real-time (RT)-PCR, and Western blotting were used to examine gene expression. The anti-invasion and anti-metastasis effects of aspirin were studied in HTATIP2-knockdown and HTATIP2-overexpressing HCC cell lines. The molecular mechanism of HTATIP2 regulation by aspirin was explored. Results: Aspirin suppressed the pro-invasion and pro-metastasis effects of sorafenib in HCC and up-regulated HTATIP2 expression. Aspirin did not inhibit the proliferation of HCC cells, but it decreased the invasiveness of HCC with lower expression of HTATIP2 and increased expression of a set of markers, indicating a mesenchymal-to-epithelial transition in tumor cells. The up-regulation of HTATPI2 expression by aspirin is most likely mediated through inhibition of cyclooxygenase (COX) 2 expression. Conclusions: Aspirin minimized the pro-metastasis effect of sorafenib by up-regulating the tumor suppressor HTATIP2; this mechanism is mediated through inhibition of COX2. [ABSTRACT FROM AUTHOR]

Published
2013
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