1. Genetic Loci for Retinal Arteriolar Microcirculation
- Author
-
Sim, X. (Xueling), Jensen, R.A. (Richard), Ikram, M.K. (Kamran), Cotch, M.F. (Mary Frances), Li, X. (Xiaohui), MacGregor, S. (Stuart), Xie, J. (Jing), Smith, A.V. (Albert Vernon), Boerwinkle, E.A. (Eric), Mitchell, P. (Paul), Klein, R. (Ronald), Klein, B.E.K. (Barbara), Glazer, N.L. (Nicole), Lumley, T. (Thomas), McKnight, B. (Barbara), Psaty, B.M. (Bruce), Jong, P.T.V.M. (Paulus) de, Hofman, A. (Albert), Rivadeneira Ramirez, F. (Fernando), Uitterlinden, A.G. (André), Duijn, C.M. (Cornelia) van, Aspelund, T. (Thor), Eiriksdottir, G. (Gudny), Harris, T.B. (Tamara), Jonasson, F. (Fridbert), Launer, L.J. (Lenore), Attia, J. (John), Baird, P.N. (Paul), Harrap, S. (Stephen), Holliday, E.G. (Elizabeth), Inouye, M. (Michael), Rochtchina, E. (Elena), Scott, R.J. (Rodney), Viswanathan, A.C. (Ananth), Li, G. (Guo), Smith, N.L. (Nicholas), Wiggins, K.L. (Kerri), Kuo, J.Z. (Jane), Taylor, K.D. (Kent), Hewit, A.W. (Alex), Martin, N.G. (Nicholas), Montgomery, G.W. (Grant), Sun, C. (Cong), Young, T.L. (Terri), Mackey, D.A. (David), Zuydam, N.R. (Natalie) van, Doney, A.S.F. (Alex), Palmer, C.N.A. (Colin), Morris, A.D. (Andrew), Rotter, J.I. (Jerome), Tai, E.S. (Shyong), Gudnason, V. (Vilmundur), Vingerling, J.R. (Hans), Siscovick, D.S. (David), Wang, J.J. (Jie Jin), Wong, T.Y. (Tien Yin), Sim, X. (Xueling), Jensen, R.A. (Richard), Ikram, M.K. (Kamran), Cotch, M.F. (Mary Frances), Li, X. (Xiaohui), MacGregor, S. (Stuart), Xie, J. (Jing), Smith, A.V. (Albert Vernon), Boerwinkle, E.A. (Eric), Mitchell, P. (Paul), Klein, R. (Ronald), Klein, B.E.K. (Barbara), Glazer, N.L. (Nicole), Lumley, T. (Thomas), McKnight, B. (Barbara), Psaty, B.M. (Bruce), Jong, P.T.V.M. (Paulus) de, Hofman, A. (Albert), Rivadeneira Ramirez, F. (Fernando), Uitterlinden, A.G. (André), Duijn, C.M. (Cornelia) van, Aspelund, T. (Thor), Eiriksdottir, G. (Gudny), Harris, T.B. (Tamara), Jonasson, F. (Fridbert), Launer, L.J. (Lenore), Attia, J. (John), Baird, P.N. (Paul), Harrap, S. (Stephen), Holliday, E.G. (Elizabeth), Inouye, M. (Michael), Rochtchina, E. (Elena), Scott, R.J. (Rodney), Viswanathan, A.C. (Ananth), Li, G. (Guo), Smith, N.L. (Nicholas), Wiggins, K.L. (Kerri), Kuo, J.Z. (Jane), Taylor, K.D. (Kent), Hewit, A.W. (Alex), Martin, N.G. (Nicholas), Montgomery, G.W. (Grant), Sun, C. (Cong), Young, T.L. (Terri), Mackey, D.A. (David), Zuydam, N.R. (Natalie) van, Doney, A.S.F. (Alex), Palmer, C.N.A. (Colin), Morris, A.D. (Andrew), Rotter, J.I. (Jerome), Tai, E.S. (Shyong), Gudnason, V. (Vilmundur), Vingerling, J.R. (Hans), Siscovick, D.S. (David), Wang, J.J. (Jie Jin), and Wong, T.Y. (Tien Yin)
- Abstract
Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value < 5 x 10(-8) This variant was replicated in an additional 3,939 individuals of European ancestry from the Australian Twins Study and Multi-Ethnic Study of Atherosclerosis (rs2194025, P-value= 2.11 x 10(-12) in combined meta-analysis of discovery and replication cohorts). In independent studies of modest sample sizes, no significant association was found between this variant and clinical outcomes including coronary artery disease, stroke, myoca
- Published
- 2013
- Full Text
- View/download PDF